Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after Stroke
Evidence is scarce regarding the polypharmacy in patients with sarcopenia. The aim of this study was to investigate the effect of deprescribing for polypharmacy on the improvement of nutritional intake and sarcopenia in older patients with sarcopenia. A retrospective cohort study was conducted with...
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MDPI AG
2022-01-01
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| Online Access: | https://www.mdpi.com/2072-6643/14/3/443 |
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| author | Ayaka Matsumoto Yoshihiro Yoshimura Hidetaka Wakabayashi Eiji Kose Fumihiko Nagano Takahiro Bise Yoshifumi Kido Sayuri Shimazu Ai Shiraishi |
| author_facet | Ayaka Matsumoto Yoshihiro Yoshimura Hidetaka Wakabayashi Eiji Kose Fumihiko Nagano Takahiro Bise Yoshifumi Kido Sayuri Shimazu Ai Shiraishi |
| author_sort | Ayaka Matsumoto |
| collection | DOAJ |
| description | Evidence is scarce regarding the polypharmacy in patients with sarcopenia. The aim of this study was to investigate the effect of deprescribing for polypharmacy on the improvement of nutritional intake and sarcopenia in older patients with sarcopenia. A retrospective cohort study was conducted with hospitalized older patients with sarcopenia undergoing rehabilitation after stroke. Study outcomes included energy intake, protein intake, handgrip strength (HG) and skeletal muscle mass index (SMI) at hospital discharge. To consider the effects of deprescribing for polypharmacy, we used multivariate analyses to examine whether the change in the number of medications during hospitalization was associated with outcomes. Of 361 patients after enrollment, 91 (mean age 81.0 years, 48.4% male) presented with sarcopenia and polypharmacy and were eligible for analysis. The change in the number of medications was independently associated with energy intake (β = −0.237, <i>p</i> = 0.009) and protein intake (β = −0.242, <i>p</i> = 0.047) at discharge, and was not statistically significantly associated with HG (β = −0.018, <i>p</i> = 0.768) and SMI (β = 0.083, <i>p</i> = 0.265) at discharge, respectively. Deprescribing was associated with improved nutritional intake in older sarcopenic patients with polypharmacy undergoing stroke rehabilitation. |
| first_indexed | 2024-03-09T23:22:36Z |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T23:22:36Z |
| publishDate | 2022-01-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-91c518b2d9b8477dafd3bae1a635a90d2023-11-23T17:23:50ZengMDPI AGNutrients2072-66432022-01-0114344310.3390/nu14030443Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after StrokeAyaka Matsumoto0Yoshihiro Yoshimura1Hidetaka Wakabayashi2Eiji Kose3Fumihiko Nagano4Takahiro Bise5Yoshifumi Kido6Sayuri Shimazu7Ai Shiraishi8Department of Pharmacy, Kumamoto Rehabilitation Hospital, Kumamoto 869-1106, JapanCenter for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto 869-1106, JapanDepartment of Rehabilitation Medicine, Tokyo Women’s Medical University Hospital, Tokyo 162-8666, JapanDepartment of Pharmacy, Teikyo University School of Medicine University Hospital, Tokyo 173-8606, JapanDepartment of Rehabilitation, Kumamoto Rehabilitation Hospital, Kumamoto 869-1106, JapanDepartment of Rehabilitation, Kumamoto Rehabilitation Hospital, Kumamoto 869-1106, JapanDepartment of Rehabilitation, Kumamoto Rehabilitation Hospital, Kumamoto 869-1106, JapanDepartment of Nutritional Management, Kumamoto Rehabilitation Hospital, Kumamoto 869-1106, JapanDepartment of Dental Office, Kumamoto Rehabilitation Hospital, Kumamoto 869-1106, JapanEvidence is scarce regarding the polypharmacy in patients with sarcopenia. The aim of this study was to investigate the effect of deprescribing for polypharmacy on the improvement of nutritional intake and sarcopenia in older patients with sarcopenia. A retrospective cohort study was conducted with hospitalized older patients with sarcopenia undergoing rehabilitation after stroke. Study outcomes included energy intake, protein intake, handgrip strength (HG) and skeletal muscle mass index (SMI) at hospital discharge. To consider the effects of deprescribing for polypharmacy, we used multivariate analyses to examine whether the change in the number of medications during hospitalization was associated with outcomes. Of 361 patients after enrollment, 91 (mean age 81.0 years, 48.4% male) presented with sarcopenia and polypharmacy and were eligible for analysis. The change in the number of medications was independently associated with energy intake (β = −0.237, <i>p</i> = 0.009) and protein intake (β = −0.242, <i>p</i> = 0.047) at discharge, and was not statistically significantly associated with HG (β = −0.018, <i>p</i> = 0.768) and SMI (β = 0.083, <i>p</i> = 0.265) at discharge, respectively. Deprescribing was associated with improved nutritional intake in older sarcopenic patients with polypharmacy undergoing stroke rehabilitation.https://www.mdpi.com/2072-6643/14/3/443polypharmacydeprescribingrehabilitation pharmacotherapysarcopeniarehabilitation nutrition |
| spellingShingle | Ayaka Matsumoto Yoshihiro Yoshimura Hidetaka Wakabayashi Eiji Kose Fumihiko Nagano Takahiro Bise Yoshifumi Kido Sayuri Shimazu Ai Shiraishi Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after Stroke Nutrients polypharmacy deprescribing rehabilitation pharmacotherapy sarcopenia rehabilitation nutrition |
| title | Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after Stroke |
| title_full | Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after Stroke |
| title_fullStr | Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after Stroke |
| title_full_unstemmed | Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after Stroke |
| title_short | Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after Stroke |
| title_sort | deprescribing leads to improved energy intake among hospitalized older sarcopenic adults with polypharmacy after stroke |
| topic | polypharmacy deprescribing rehabilitation pharmacotherapy sarcopenia rehabilitation nutrition |
| url | https://www.mdpi.com/2072-6643/14/3/443 |
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