Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-Up
<i>Background:</i> Obstructive sleep apnea increases (OSA) cognitive impairment risk. The objective of this study was to determine the impact of continuous positive airway pressure (CPAP) adherence on global cognition using the Montreal Cognitive Assessment questionnaire (MoCA). <i>...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/59/5/846 |
| _version_ | 1797599205886263296 |
|---|---|
| author | Diana Raluca Velescu Monica Steluta Marc Camelia Corina Pescaru Daniel Traila Emanuela Vaștag Ion Papava Alexandru Catalin Motofelea Ioana Mihaiela Ciuca Diana Manolescu Cristian Oancea |
| author_facet | Diana Raluca Velescu Monica Steluta Marc Camelia Corina Pescaru Daniel Traila Emanuela Vaștag Ion Papava Alexandru Catalin Motofelea Ioana Mihaiela Ciuca Diana Manolescu Cristian Oancea |
| author_sort | Diana Raluca Velescu |
| collection | DOAJ |
| description | <i>Background:</i> Obstructive sleep apnea increases (OSA) cognitive impairment risk. The objective of this study was to determine the impact of continuous positive airway pressure (CPAP) adherence on global cognition using the Montreal Cognitive Assessment questionnaire (MoCA). <i>Materials and Methods:</i> Thirty-four new patients diagnosed with moderate or severe OSA (apnea-hypopnea index AHI ≥ 15 events/h) from the CPAP group were compared with thirty-one moderate to severe OSA patients from the no-CPAP group. In addition, all patients completed the MoCA test, a patient health questionnaire (PHQ-9) for depressive symptoms, and a generalized anxiety questionnaire (GAD-7) for anxiety symptoms, at baseline, after 6 months, and after 1 year. <i>Results:</i> At baseline, there were no significant differences between the two groups regarding total MoCA scores, 20.9 ± 3.5 CPAP group to 19.7 ± 2.9 no-CPAP group (<i>p</i> = 0.159), PHQ-9 (<i>p</i> = 0.651), and GAD-7 (<i>p</i> = 0.691). After one year, improvement was observed for a total MoCA score of 22.7 ± 3.5 (<i>p</i> < 0.001) for the CPAP group, and significant variance of score between groups was more accentuated for delayed recall and attention (<i>p</i> < 0.001) sub-topic. Moreover, PHQ-9, GAD-7 scores, and the Epworth Sleepiness Scale (ESS) decreased significantly (<i>p</i> < 0.001) after CPAP therapy. The MoCA score was significantly correlated with years of education (r = 0.74, <i>p</i> < 0.001) and had a negative correlation with body mass index (BMI) (r = −0.34), ESS (r = −0.30) and PHQ-9 (r = −0.34). <i>Conclusions:</i> One year of CPAP adherence improved global cognition associated with OSA. |
| first_indexed | 2024-03-11T03:31:26Z |
| format | Article |
| id | doaj.art-91c887c3a9d848229d0b1e78ec249735 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T03:31:26Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-91c887c3a9d848229d0b1e78ec2497352023-11-18T02:21:06ZengMDPI AGMedicina1010-660X1648-91442023-04-0159584610.3390/medicina59050846Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-UpDiana Raluca Velescu0Monica Steluta Marc1Camelia Corina Pescaru2Daniel Traila3Emanuela Vaștag4Ion Papava5Alexandru Catalin Motofelea6Ioana Mihaiela Ciuca7Diana Manolescu8Cristian Oancea9Pulmonary Department, Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), ‘Victor Babes’ University of Medicine and Pharmacy, 300041 Timisoara, RomaniaPulmonary Department, Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), ‘Victor Babes’ University of Medicine and Pharmacy, 300041 Timisoara, RomaniaPulmonary Department, Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), ‘Victor Babes’ University of Medicine and Pharmacy, 300041 Timisoara, RomaniaPulmonary Department, Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), ‘Victor Babes’ University of Medicine and Pharmacy, 300041 Timisoara, RomaniaPulmonary Department, Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), ‘Victor Babes’ University of Medicine and Pharmacy, 300041 Timisoara, RomaniaNeuroscience Department, NEUROPSY—COG Center for Cognitive Research in Neuropsychiatric Pathology, ‘Victor Babes’, University of Medicine and Pharmacy, 300041 Timisoara, RomaniaInternal Medicine Department, ‘Victor Babes’ University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq, 300041 Timisoara, RomaniaPediatric Department, ‘Victor Babes’ University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, RomaniaPulmonary Department, Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), ‘Victor Babes’ University of Medicine and Pharmacy, 300041 Timisoara, RomaniaPulmonary Department, Center for Research and Innovation in Precision Medicine of Respiratory Diseases (CRIPMRD), ‘Victor Babes’ University of Medicine and Pharmacy, 300041 Timisoara, Romania<i>Background:</i> Obstructive sleep apnea increases (OSA) cognitive impairment risk. The objective of this study was to determine the impact of continuous positive airway pressure (CPAP) adherence on global cognition using the Montreal Cognitive Assessment questionnaire (MoCA). <i>Materials and Methods:</i> Thirty-four new patients diagnosed with moderate or severe OSA (apnea-hypopnea index AHI ≥ 15 events/h) from the CPAP group were compared with thirty-one moderate to severe OSA patients from the no-CPAP group. In addition, all patients completed the MoCA test, a patient health questionnaire (PHQ-9) for depressive symptoms, and a generalized anxiety questionnaire (GAD-7) for anxiety symptoms, at baseline, after 6 months, and after 1 year. <i>Results:</i> At baseline, there were no significant differences between the two groups regarding total MoCA scores, 20.9 ± 3.5 CPAP group to 19.7 ± 2.9 no-CPAP group (<i>p</i> = 0.159), PHQ-9 (<i>p</i> = 0.651), and GAD-7 (<i>p</i> = 0.691). After one year, improvement was observed for a total MoCA score of 22.7 ± 3.5 (<i>p</i> < 0.001) for the CPAP group, and significant variance of score between groups was more accentuated for delayed recall and attention (<i>p</i> < 0.001) sub-topic. Moreover, PHQ-9, GAD-7 scores, and the Epworth Sleepiness Scale (ESS) decreased significantly (<i>p</i> < 0.001) after CPAP therapy. The MoCA score was significantly correlated with years of education (r = 0.74, <i>p</i> < 0.001) and had a negative correlation with body mass index (BMI) (r = −0.34), ESS (r = −0.30) and PHQ-9 (r = −0.34). <i>Conclusions:</i> One year of CPAP adherence improved global cognition associated with OSA.https://www.mdpi.com/1648-9144/59/5/846cognitionobstructive sleep apneacontinuous positive airway pressureadherence |
| spellingShingle | Diana Raluca Velescu Monica Steluta Marc Camelia Corina Pescaru Daniel Traila Emanuela Vaștag Ion Papava Alexandru Catalin Motofelea Ioana Mihaiela Ciuca Diana Manolescu Cristian Oancea Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-Up Medicina cognition obstructive sleep apnea continuous positive airway pressure adherence |
| title | Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-Up |
| title_full | Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-Up |
| title_fullStr | Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-Up |
| title_full_unstemmed | Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-Up |
| title_short | Impact of CPAP Therapy Adherence on Global Cognition in Patients with Moderate to Severe Obstructive Sleep Apnea: A One-Year Follow-Up |
| title_sort | impact of cpap therapy adherence on global cognition in patients with moderate to severe obstructive sleep apnea a one year follow up |
| topic | cognition obstructive sleep apnea continuous positive airway pressure adherence |
| url | https://www.mdpi.com/1648-9144/59/5/846 |
| work_keys_str_mv | AT dianaralucavelescu impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT monicastelutamarc impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT cameliacorinapescaru impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT danieltraila impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT emanuelavastag impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT ionpapava impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT alexandrucatalinmotofelea impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT ioanamihaielaciuca impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT dianamanolescu impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup AT cristianoancea impactofcpaptherapyadherenceonglobalcognitioninpatientswithmoderatetosevereobstructivesleepapneaaoneyearfollowup |