Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing
The human–bacterial association is long-known and well-established in terms of both augmentations of human health and attenuation. However, the growing incidents of nosocomial infections caused by the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1159798/full |
| _version_ | 1797792306825265152 |
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| author | Parvathy Venkateswaran Sahana Vasudevan Helma David Adityan Shaktivel Karthik Shanmugam Prasanna Neelakantan Adline Princy Solomon |
| author_facet | Parvathy Venkateswaran Sahana Vasudevan Helma David Adityan Shaktivel Karthik Shanmugam Prasanna Neelakantan Adline Princy Solomon |
| author_sort | Parvathy Venkateswaran |
| collection | DOAJ |
| description | The human–bacterial association is long-known and well-established in terms of both augmentations of human health and attenuation. However, the growing incidents of nosocomial infections caused by the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.) call for a much deeper understanding of these organisms. Adopting a holistic approach that includes the science of infection and the recent advancements in preventing and treating infections is imperative in designing novel intervention strategies against ESKAPE pathogens. In this regard, this review captures the ingenious strategies commissioned by these master players, which are teamed up against the defenses of the human team, that are equally, if not more, versatile and potent through an analogy. We have taken a basketball match as our analogy, dividing the human and bacterial species into two teams playing with the ball of health. Through this analogy, we make the concept of infectious biology more accessible. |
| first_indexed | 2024-03-13T02:31:17Z |
| format | Article |
| id | doaj.art-91cbfcc16a9f469c9a886c36e26d6dd9 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-13T02:31:17Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-91cbfcc16a9f469c9a886c36e26d6dd92023-06-29T15:29:33ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-06-011310.3389/fcimb.2023.11597981159798Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensingParvathy Venkateswaran0Sahana Vasudevan1Helma David2Adityan Shaktivel3Karthik Shanmugam4Prasanna Neelakantan5Adline Princy Solomon6Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, IndiaQuorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, IndiaQuorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, IndiaQuorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, IndiaQuorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, IndiaDivision of Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaQuorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, IndiaThe human–bacterial association is long-known and well-established in terms of both augmentations of human health and attenuation. However, the growing incidents of nosocomial infections caused by the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.) call for a much deeper understanding of these organisms. Adopting a holistic approach that includes the science of infection and the recent advancements in preventing and treating infections is imperative in designing novel intervention strategies against ESKAPE pathogens. In this regard, this review captures the ingenious strategies commissioned by these master players, which are teamed up against the defenses of the human team, that are equally, if not more, versatile and potent through an analogy. We have taken a basketball match as our analogy, dividing the human and bacterial species into two teams playing with the ball of health. Through this analogy, we make the concept of infectious biology more accessible.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1159798/fullESKAPEvirulenceantimicrobial resistancebiofilmquorum sensing |
| spellingShingle | Parvathy Venkateswaran Sahana Vasudevan Helma David Adityan Shaktivel Karthik Shanmugam Prasanna Neelakantan Adline Princy Solomon Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing Frontiers in Cellular and Infection Microbiology ESKAPE virulence antimicrobial resistance biofilm quorum sensing |
| title | Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing |
| title_full | Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing |
| title_fullStr | Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing |
| title_full_unstemmed | Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing |
| title_short | Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing |
| title_sort | revisiting eskape pathogens virulence resistance and combating strategies focusing on quorum sensing |
| topic | ESKAPE virulence antimicrobial resistance biofilm quorum sensing |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1159798/full |
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