Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosis
Kok-Yong Chin,1 Nie Yen Low,2 Alia Annessa Ain Kamaruddin,2 Wan Ilma Dewiputri,2 Ima-Nirwana Soelaiman1 1Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Malaysia; 2ASASIpintar Foundation Program, PERMATApintar National Gifted Centre, Universiti Kebangsaan Malaysia...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-10-01
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| Series: | Therapeutics and Clinical Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/agreement-between-calcaneal-quantitative-ultrasound-and-osteoporosis-s-peer-reviewed-article-TCRM |
| _version_ | 1818989909702082560 |
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| author | Chin KY Low NY Kamaruddin AAA Dewiputri WI Soelaiman IN |
| author_facet | Chin KY Low NY Kamaruddin AAA Dewiputri WI Soelaiman IN |
| author_sort | Chin KY |
| collection | DOAJ |
| description | Kok-Yong Chin,1 Nie Yen Low,2 Alia Annessa Ain Kamaruddin,2 Wan Ilma Dewiputri,2 Ima-Nirwana Soelaiman1 1Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Malaysia; 2ASASIpintar Foundation Program, PERMATApintar National Gifted Centre, Universiti Kebangsaan Malaysia, Bangi, Malaysia Background: Calcaneal quantitative ultrasound (QUS) is a useful tool in osteoporosis screening. However, QUS device may not be available at all primary health care settings. Osteoporosis self-assessment tool for Asians (OSTA) is a simple algorithm for osteoporosis screening that does not require any sophisticated instruments. This study explored the possibility of replacing QUS with OSTA by determining their agreement in identifying individuals at risk of osteoporosis. Methods: A cross-sectional study was conducted to recruit Malaysian men and women aged ≥50 years. Their bone health status was measured using a calcaneal QUS device and OSTA. The association between OSTA and QUS was determined using Spearman’s correlation and their agreement was assessed using Cohen Kappa and receiver-operating curve. Results: All QUS indices correlated significantly with OSTA (p<0.05). The agreement between QUS and OSTA was minimal but statistically significant (p<0.05). The performance of OSTA in identifying subjects at risk of osteoporosis according to QUS was poor-to-fair in women (p<0.05), but not statistically significant for men (p>0.05). Changing the cut-off values improved the performance of OSTA in women but not in men. Conclusion: The agreement between QUS and OSTA is minimal in categorizing individuals at risk of osteoporosis. Therefore, they cannot be used interchangeably in osteoporosis screening. Keywords: bone, correlation, osteopenia, ROC, sensitivity, specificity |
| first_indexed | 2024-12-20T19:45:58Z |
| format | Article |
| id | doaj.art-91cd3562afff4b4cb33ffef6b88f1f43 |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-20T19:45:58Z |
| publishDate | 2017-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-91cd3562afff4b4cb33ffef6b88f1f432022-12-21T19:28:25ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2017-10-01Volume 131333134135070Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosisChin KYLow NYKamaruddin AAADewiputri WISoelaiman INKok-Yong Chin,1 Nie Yen Low,2 Alia Annessa Ain Kamaruddin,2 Wan Ilma Dewiputri,2 Ima-Nirwana Soelaiman1 1Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Malaysia; 2ASASIpintar Foundation Program, PERMATApintar National Gifted Centre, Universiti Kebangsaan Malaysia, Bangi, Malaysia Background: Calcaneal quantitative ultrasound (QUS) is a useful tool in osteoporosis screening. However, QUS device may not be available at all primary health care settings. Osteoporosis self-assessment tool for Asians (OSTA) is a simple algorithm for osteoporosis screening that does not require any sophisticated instruments. This study explored the possibility of replacing QUS with OSTA by determining their agreement in identifying individuals at risk of osteoporosis. Methods: A cross-sectional study was conducted to recruit Malaysian men and women aged ≥50 years. Their bone health status was measured using a calcaneal QUS device and OSTA. The association between OSTA and QUS was determined using Spearman’s correlation and their agreement was assessed using Cohen Kappa and receiver-operating curve. Results: All QUS indices correlated significantly with OSTA (p<0.05). The agreement between QUS and OSTA was minimal but statistically significant (p<0.05). The performance of OSTA in identifying subjects at risk of osteoporosis according to QUS was poor-to-fair in women (p<0.05), but not statistically significant for men (p>0.05). Changing the cut-off values improved the performance of OSTA in women but not in men. Conclusion: The agreement between QUS and OSTA is minimal in categorizing individuals at risk of osteoporosis. Therefore, they cannot be used interchangeably in osteoporosis screening. Keywords: bone, correlation, osteopenia, ROC, sensitivity, specificityhttps://www.dovepress.com/agreement-between-calcaneal-quantitative-ultrasound-and-osteoporosis-s-peer-reviewed-article-TCRMbonecorrelationosteopeniaROC curvesensitivityspecificity |
| spellingShingle | Chin KY Low NY Kamaruddin AAA Dewiputri WI Soelaiman IN Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosis Therapeutics and Clinical Risk Management bone correlation osteopenia ROC curve sensitivity specificity |
| title | Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosis |
| title_full | Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosis |
| title_fullStr | Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosis |
| title_full_unstemmed | Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosis |
| title_short | Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosis |
| title_sort | agreement between calcaneal quantitative ultrasound and osteoporosis self assessment tool for asians in identifying individuals at risk of osteoporosis |
| topic | bone correlation osteopenia ROC curve sensitivity specificity |
| url | https://www.dovepress.com/agreement-between-calcaneal-quantitative-ultrasound-and-osteoporosis-s-peer-reviewed-article-TCRM |
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