Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific Australia
Objective: To look into the glucose tolerance test characteristics and determine complications in non-gestational diabetes pregnant subjects. Methods: From 2006 to 2009 all non-gestational diabetes mellitus (non-GDM) pregnant women who delivered macrosomia at the North Australia's Townsville Ho...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-06-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169115302197 |
| _version_ | 1818158738916245504 |
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| author | Algenes Aranha Usman H Malabu Venkat Vangaveti Elham Saleh Reda Yong Mong Tan Kunwarjit Singh Sangla |
| author_facet | Algenes Aranha Usman H Malabu Venkat Vangaveti Elham Saleh Reda Yong Mong Tan Kunwarjit Singh Sangla |
| author_sort | Algenes Aranha |
| collection | DOAJ |
| description | Objective: To look into the glucose tolerance test characteristics and determine complications in non-gestational diabetes pregnant subjects.
Methods: From 2006 to 2009 all non-gestational diabetes mellitus (non-GDM) pregnant women who delivered macrosomia at the North Australia's Townsville Hospital were retrospectively reviewed by extracting data from clinical record. Glucose tolerance tests results were analysed in the light of an earlier diagnosis of non-GDM.
Results: Ninety-one non-GDM mothers with macrosomia were studied and compared with 41 normoglycemic subjects without macrosomia. Of the subjects with non-GDM macrosomia, 45 (49.4%) had normal 50 g glucose challenge test (GCT) without further testing, another 8 (8.8%) had abnormal GCT but normal 75 g oral glucose tolerance test (OGTT). A total of 4 (4.4%) subjects had normal GCT and OGTT. Interestingly, 14 out of 16 (87.5%) subjects who were tested with OGTT owing to past history of macrosomia had normal results but delivered macrosomic babies. Only 12 subjects had both GCT and OGTT, the rest of the cohort had either of the two tests. Subjects with non-GDM macrosomia had higher frequency of neonatal hypoglycaemia 34% as compared to 10% in non-macrosomic babies (P=0.003). Other feto-maternal complications were similar in both groups.
Conclusions: No significant pattern of glucose tolerance characteristics was identified in non-GDM mothers with macrosomic babies. In spite of being normoglycemic significant neonatal hypoglycaemia was recorded in non-GDM macrosomic babies. Further prospective studies on a larger population are needed to verify our findings. |
| first_indexed | 2024-12-11T15:34:52Z |
| format | Article |
| id | doaj.art-91cd37d1f90a41b39f2880725be99214 |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-12-11T15:34:52Z |
| publishDate | 2014-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-91cd37d1f90a41b39f2880725be992142022-12-22T00:59:58ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912014-06-014643644010.12980/APJTB.4.2014APJTB-2013-0027Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific AustraliaAlgenes Aranha0Usman H Malabu1Venkat Vangaveti2Elham Saleh Reda3Yong Mong Tan4Kunwarjit Singh Sangla5Mater Private Hospital, 21-37 Fulham Road, Townsville, Queensland 4812, AustraliaTownsville Hospital, Department of Diabetes & Endocrinology, 100 Angus Smith Drive, Townsville, Queensland, Australia 4814School of Medicine & Dentistry, James Cook University, School of Medicine, 1 James Cook Drive Townsville, Queensland, Australia 4811Gold Coast Hospital, Diabetes & Endocrinology, 1 Hospital Boulevard, Southport, Gold Coast, Queensland, Australia 4215Townsville Hospital, Department of Diabetes & Endocrinology, 100 Angus Smith Drive, Townsville, Queensland, Australia 4814Townsville Hospital, Department of Diabetes & Endocrinology, 100 Angus Smith Drive, Townsville, Queensland, Australia 4814Objective: To look into the glucose tolerance test characteristics and determine complications in non-gestational diabetes pregnant subjects. Methods: From 2006 to 2009 all non-gestational diabetes mellitus (non-GDM) pregnant women who delivered macrosomia at the North Australia's Townsville Hospital were retrospectively reviewed by extracting data from clinical record. Glucose tolerance tests results were analysed in the light of an earlier diagnosis of non-GDM. Results: Ninety-one non-GDM mothers with macrosomia were studied and compared with 41 normoglycemic subjects without macrosomia. Of the subjects with non-GDM macrosomia, 45 (49.4%) had normal 50 g glucose challenge test (GCT) without further testing, another 8 (8.8%) had abnormal GCT but normal 75 g oral glucose tolerance test (OGTT). A total of 4 (4.4%) subjects had normal GCT and OGTT. Interestingly, 14 out of 16 (87.5%) subjects who were tested with OGTT owing to past history of macrosomia had normal results but delivered macrosomic babies. Only 12 subjects had both GCT and OGTT, the rest of the cohort had either of the two tests. Subjects with non-GDM macrosomia had higher frequency of neonatal hypoglycaemia 34% as compared to 10% in non-macrosomic babies (P=0.003). Other feto-maternal complications were similar in both groups. Conclusions: No significant pattern of glucose tolerance characteristics was identified in non-GDM mothers with macrosomic babies. In spite of being normoglycemic significant neonatal hypoglycaemia was recorded in non-GDM macrosomic babies. Further prospective studies on a larger population are needed to verify our findings.http://www.sciencedirect.com/science/article/pii/S2221169115302197Non-gestational diabetesMacrosomiaGlucose tolerance test characteristicsPregnancy |
| spellingShingle | Algenes Aranha Usman H Malabu Venkat Vangaveti Elham Saleh Reda Yong Mong Tan Kunwarjit Singh Sangla Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific Australia Asian Pacific Journal of Tropical Biomedicine Non-gestational diabetes Macrosomia Glucose tolerance test characteristics Pregnancy |
| title | Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific Australia |
| title_full | Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific Australia |
| title_fullStr | Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific Australia |
| title_full_unstemmed | Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific Australia |
| title_short | Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific Australia |
| title_sort | macrosomia in non gestational diabetes pregnancy glucose tolerance test characteristics and feto maternal complications in tropical asia pacific australia |
| topic | Non-gestational diabetes Macrosomia Glucose tolerance test characteristics Pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S2221169115302197 |
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