Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells

Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells

Summary: Induced pluripotent stem cells (iPSCs) are the foundation of cell therapy. Differences in gene expression, DNA methylation, and chromatin conformation, which could affect differentiation capacity, have been identified between iPSCs and embryonic stem cells (ESCs). Less is known about whethe...

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Bibliographic Details
Main Authors: Matthew M. Edwards, Ning Wang, Dashiell J. Massey, Sakshi Bhatele, Dieter Egli, Amnon Koren
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Reports
Subjects:
CP: Stem cell research
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723016753

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