Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–2017
Data are limited on the incidence and management of streptococcal toxic shock syndrome (TSS) and nonstreptococcal TSS in children. We aimed to define the clinical patterns of TSS at Nationwide Children’s Hospital in Ohio as they relate to published criteria, diagnostic decisions, and treatment optio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2020-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/26/6/19-0783_article |
| _version_ | 1818607633451450368 |
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| author | Aliza Cook Sarah Janse Joshua R. Watson Guliz Erdem |
| author_facet | Aliza Cook Sarah Janse Joshua R. Watson Guliz Erdem |
| author_sort | Aliza Cook |
| collection | DOAJ |
| description | Data are limited on the incidence and management of streptococcal toxic shock syndrome (TSS) and nonstreptococcal TSS in children. We aimed to define the clinical patterns of TSS at Nationwide Children’s Hospital in Ohio as they relate to published criteria, diagnostic decisions, and treatment options. Through retrospective chart reviews, we identified 58 patients with TSS (27 streptococcal, 31 nonstreptococcal) during January 2010–September 2017. We observed clinical and laboratory findings that are not part of TSS criteria, such as pyuria in streptococcal TSS (50% of patients) and pulmonary involvement (85%) and coagulopathy (92%) in nonstreptococcal TSS patients. Recommended treatment with clindamycin and intravenous immunoglobulin was delayed in streptococcal TSS patients without rash (3.37 days vs. 0.87 days in patients with rash), leading to prolonged hospitalization and complications. Incorporation of additional TSS signs and symptoms would be helpful in TSS diagnosis and management. |
| first_indexed | 2024-12-16T14:29:51Z |
| format | Article |
| id | doaj.art-91d0436be89a4274b46ddccbfb98221c |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-16T14:29:51Z |
| publishDate | 2020-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-91d0436be89a4274b46ddccbfb98221c2022-12-21T22:28:16ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592020-06-012661077108310.3201/eid2606.190783Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–2017Aliza CookSarah JanseJoshua R. WatsonGuliz ErdemData are limited on the incidence and management of streptococcal toxic shock syndrome (TSS) and nonstreptococcal TSS in children. We aimed to define the clinical patterns of TSS at Nationwide Children’s Hospital in Ohio as they relate to published criteria, diagnostic decisions, and treatment options. Through retrospective chart reviews, we identified 58 patients with TSS (27 streptococcal, 31 nonstreptococcal) during January 2010–September 2017. We observed clinical and laboratory findings that are not part of TSS criteria, such as pyuria in streptococcal TSS (50% of patients) and pulmonary involvement (85%) and coagulopathy (92%) in nonstreptococcal TSS patients. Recommended treatment with clindamycin and intravenous immunoglobulin was delayed in streptococcal TSS patients without rash (3.37 days vs. 0.87 days in patients with rash), leading to prolonged hospitalization and complications. Incorporation of additional TSS signs and symptoms would be helpful in TSS diagnosis and management.https://wwwnc.cdc.gov/eid/article/26/6/19-0783_articleToxic shock syndromestreptococcal TSSnonstreptococcal TSSchildrendiagnostic criteriaclindamycin |
| spellingShingle | Aliza Cook Sarah Janse Joshua R. Watson Guliz Erdem Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–2017 Emerging Infectious Diseases Toxic shock syndrome streptococcal TSS nonstreptococcal TSS children diagnostic criteria clindamycin |
| title | Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–2017 |
| title_full | Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–2017 |
| title_fullStr | Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–2017 |
| title_full_unstemmed | Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–2017 |
| title_short | Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010–2017 |
| title_sort | manifestations of toxic shock syndrome in children columbus ohio usa 2010 2017 |
| topic | Toxic shock syndrome streptococcal TSS nonstreptococcal TSS children diagnostic criteria clindamycin |
| url | https://wwwnc.cdc.gov/eid/article/26/6/19-0783_article |
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