Effects of caffeine on learning and memory in rats tested in the Morris water maze
We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2002-10-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000013 |
| _version_ | 1819088193353416704 |
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| author | M.E.M. Angelucci C. Cesário R.H. Hiroi P.L. Rosalen C. Da Cunha |
| author_facet | M.E.M. Angelucci C. Cesário R.H. Hiroi P.L. Rosalen C. Da Cunha |
| author_sort | M.E.M. Angelucci |
| collection | DOAJ |
| description | We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, P<=0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats was up to 500 cm shorter, P<=0.05). In contrast, pre-training caffeine administration did not alter the performance of the animals either in the training or in the test session. These data provide evidence that caffeine improves memory retention but not memory acquisition, explaining some discrepancies among reports in the literature. |
| first_indexed | 2024-12-21T21:48:09Z |
| format | Article |
| id | doaj.art-91d0f7de532945558ae1ae49f9f79965 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-21T21:48:09Z |
| publishDate | 2002-10-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-91d0f7de532945558ae1ae49f9f799652022-12-21T18:49:10ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2002-10-0135101201120810.1590/S0100-879X2002001000013Effects of caffeine on learning and memory in rats tested in the Morris water mazeM.E.M. AngelucciC. CesárioR.H. HiroiP.L. RosalenC. Da CunhaWe studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, P<=0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats was up to 500 cm shorter, P<=0.05). In contrast, pre-training caffeine administration did not alter the performance of the animals either in the training or in the test session. These data provide evidence that caffeine improves memory retention but not memory acquisition, explaining some discrepancies among reports in the literature.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000013MemoryLearningCaffeineMethylxanthinesAdenosine receptor antagonistMorris water maze |
| spellingShingle | M.E.M. Angelucci C. Cesário R.H. Hiroi P.L. Rosalen C. Da Cunha Effects of caffeine on learning and memory in rats tested in the Morris water maze Brazilian Journal of Medical and Biological Research Memory Learning Caffeine Methylxanthines Adenosine receptor antagonist Morris water maze |
| title | Effects of caffeine on learning and memory in rats tested in the Morris water maze |
| title_full | Effects of caffeine on learning and memory in rats tested in the Morris water maze |
| title_fullStr | Effects of caffeine on learning and memory in rats tested in the Morris water maze |
| title_full_unstemmed | Effects of caffeine on learning and memory in rats tested in the Morris water maze |
| title_short | Effects of caffeine on learning and memory in rats tested in the Morris water maze |
| title_sort | effects of caffeine on learning and memory in rats tested in the morris water maze |
| topic | Memory Learning Caffeine Methylxanthines Adenosine receptor antagonist Morris water maze |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000013 |
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