The Chaperone and Redox Properties of CnoX Chaperedoxins Are Tailored to the Proteostatic Needs of Bacterial Species

The Chaperone and Redox Properties of CnoX Chaperedoxins Are Tailored to the Proteostatic Needs of Bacterial Species

ABSTRACT Hypochlorous acid (bleach), an oxidizing compound produced by neutrophils, turns the Escherichia coli chaperedoxin CnoX into a powerful holdase protecting its substrates from bleach-induced aggregation. CnoX is well conserved in bacteria, even in non-infectious species unlikely to encounter...

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Bibliographic Details
Main Authors: Camille V. Goemans, François Beaufay, Isabelle S. Arts, Rym Agrebi, Didier Vertommen, Jean-François Collet
Format: Article
Language:English
Published: American Society for Microbiology 2018-12-01
Series:mBio
Subjects:
chaperones
oxidative stress
protein folding
thioredoxin
Online Access:https://journals.asm.org/doi/10.1128/mBio.01541-18

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