Toxicity in Peripheral Nerves: An Overview
Introduction to a collection. This article is intended to introduce a collection of papers on toxic neuropathies. Toxic neuropathies can be caused by a variety of substances and by different mechanisms. Toxic agents are numerous and can be distinguished between drugs, recreational agents, heavy meta...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/9/9/218 |
| _version_ | 1797517079553769472 |
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| author | Wolfgang Grisold Valentina Alda Carozzi |
| author_facet | Wolfgang Grisold Valentina Alda Carozzi |
| author_sort | Wolfgang Grisold |
| collection | DOAJ |
| description | Introduction to a collection. This article is intended to introduce a collection of papers on toxic neuropathies. Toxic neuropathies can be caused by a variety of substances and by different mechanisms. Toxic agents are numerous and can be distinguished between drugs, recreational agents, heavy metals, industrial agents, pesticides, warfare agents, biologic substances and venoms. Toxic agents reach the nervous system by ingestion, transcutaneously, via the mucous membranes, parenterally and by aerosols. The most frequent types are cumulative toxicities. Other types are acute or delayed toxicities. Pathogenetic mechanisms range from a specific toxic substance profile causing axonal or demyelinating lesions, towards ion channel interferences, immune-mediated mechanisms and a number of different molecular pathways. In addition, demyelination, focal lesions and small fiber damage may occur. Clinically, neurotoxicity presents most frequently as axonal symmetric neuropathies. In this work, we present a panoramic view of toxic neuropathy, in terms of symptoms, causes, mechanisms and classification. |
| first_indexed | 2024-03-10T07:09:48Z |
| format | Article |
| id | doaj.art-91d1914380a54ff3ac754403db4b977e |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T07:09:48Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-91d1914380a54ff3ac754403db4b977e2023-11-22T15:30:28ZengMDPI AGToxics2305-63042021-09-019921810.3390/toxics9090218Toxicity in Peripheral Nerves: An OverviewWolfgang Grisold0Valentina Alda Carozzi1Ludwig Boltzmann Institute for Experimental und Clinical Traumatology, Donaueschingenstraße 13, A-1200 Wien, AustriaExperimental Neurology Unit, School of Medicine and Surgery, University of Milan Bicocca, Building U8, Room 1027, Via Cadore 48, 20900 Monza, ItalyIntroduction to a collection. This article is intended to introduce a collection of papers on toxic neuropathies. Toxic neuropathies can be caused by a variety of substances and by different mechanisms. Toxic agents are numerous and can be distinguished between drugs, recreational agents, heavy metals, industrial agents, pesticides, warfare agents, biologic substances and venoms. Toxic agents reach the nervous system by ingestion, transcutaneously, via the mucous membranes, parenterally and by aerosols. The most frequent types are cumulative toxicities. Other types are acute or delayed toxicities. Pathogenetic mechanisms range from a specific toxic substance profile causing axonal or demyelinating lesions, towards ion channel interferences, immune-mediated mechanisms and a number of different molecular pathways. In addition, demyelination, focal lesions and small fiber damage may occur. Clinically, neurotoxicity presents most frequently as axonal symmetric neuropathies. In this work, we present a panoramic view of toxic neuropathy, in terms of symptoms, causes, mechanisms and classification.https://www.mdpi.com/2305-6304/9/9/218toxic agentsperipheral neuropathyperipheral nervedorsal root gangliapathogenetic mechanisms |
| spellingShingle | Wolfgang Grisold Valentina Alda Carozzi Toxicity in Peripheral Nerves: An Overview Toxics toxic agents peripheral neuropathy peripheral nerve dorsal root ganglia pathogenetic mechanisms |
| title | Toxicity in Peripheral Nerves: An Overview |
| title_full | Toxicity in Peripheral Nerves: An Overview |
| title_fullStr | Toxicity in Peripheral Nerves: An Overview |
| title_full_unstemmed | Toxicity in Peripheral Nerves: An Overview |
| title_short | Toxicity in Peripheral Nerves: An Overview |
| title_sort | toxicity in peripheral nerves an overview |
| topic | toxic agents peripheral neuropathy peripheral nerve dorsal root ganglia pathogenetic mechanisms |
| url | https://www.mdpi.com/2305-6304/9/9/218 |
| work_keys_str_mv | AT wolfganggrisold toxicityinperipheralnervesanoverview AT valentinaaldacarozzi toxicityinperipheralnervesanoverview |