Injury-activated glial cells promote wound healing of the adult skin in mice
The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01488-2 |
| _version_ | 1830449372040527872 |
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| author | Vadims Parfejevs Julien Debbache Olga Shakhova Simon M. Schaefer Mareen Glausch Michael Wegner Ueli Suter Una Riekstina Sabine Werner Lukas Sommer |
| author_facet | Vadims Parfejevs Julien Debbache Olga Shakhova Simon M. Schaefer Mareen Glausch Michael Wegner Ueli Suter Una Riekstina Sabine Werner Lukas Sommer |
| author_sort | Vadims Parfejevs |
| collection | DOAJ |
| description | The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing. |
| first_indexed | 2024-12-21T07:55:48Z |
| format | Article |
| id | doaj.art-91d26ea46e384fdb9e27908430c6b644 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T07:55:48Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-91d26ea46e384fdb9e27908430c6b6442022-12-21T19:11:00ZengNature PortfolioNature Communications2041-17232018-01-019111610.1038/s41467-017-01488-2Injury-activated glial cells promote wound healing of the adult skin in miceVadims Parfejevs0Julien Debbache1Olga Shakhova2Simon M. Schaefer3Mareen Glausch4Michael Wegner5Ueli Suter6Una Riekstina7Sabine Werner8Lukas Sommer9Institute of Anatomy, University of ZürichInstitute of Anatomy, University of ZürichDepartment of Oncology, University Hospital ZürichInstitute of Anatomy, University of ZürichInstitute of Anatomy, University of ZürichInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-NürnbergInstitute of Molecular Health Sciences, ETHFaculty of Medicine, University of LatviaInstitute of Molecular Health Sciences, ETHInstitute of Anatomy, University of ZürichThe peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing.https://doi.org/10.1038/s41467-017-01488-2 |
| spellingShingle | Vadims Parfejevs Julien Debbache Olga Shakhova Simon M. Schaefer Mareen Glausch Michael Wegner Ueli Suter Una Riekstina Sabine Werner Lukas Sommer Injury-activated glial cells promote wound healing of the adult skin in mice Nature Communications |
| title | Injury-activated glial cells promote wound healing of the adult skin in mice |
| title_full | Injury-activated glial cells promote wound healing of the adult skin in mice |
| title_fullStr | Injury-activated glial cells promote wound healing of the adult skin in mice |
| title_full_unstemmed | Injury-activated glial cells promote wound healing of the adult skin in mice |
| title_short | Injury-activated glial cells promote wound healing of the adult skin in mice |
| title_sort | injury activated glial cells promote wound healing of the adult skin in mice |
| url | https://doi.org/10.1038/s41467-017-01488-2 |
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