Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment
Tumor immunosuppression may assist the immune escape of cancer cells, which promotes tumor metastasis and resistance to chemo-radiotherapy. The therapeutic strategies against tumor immunosuppression mainly focus on blocking immune checkpoint receptors, enhancing T-cell recognition and neutralizing i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00048/full |
| _version_ | 1831636593125883904 |
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| author | Ya Luo Jiqiao Yang Jiqiao Yang Jing Yu Xiaowei Liu Chune Yu Jianping Hu Hubing Shi Xuelei Ma Xuelei Ma |
| author_facet | Ya Luo Jiqiao Yang Jiqiao Yang Jing Yu Xiaowei Liu Chune Yu Jianping Hu Hubing Shi Xuelei Ma Xuelei Ma |
| author_sort | Ya Luo |
| collection | DOAJ |
| description | Tumor immunosuppression may assist the immune escape of cancer cells, which promotes tumor metastasis and resistance to chemo-radiotherapy. The therapeutic strategies against tumor immunosuppression mainly focus on blocking immune checkpoint receptors, enhancing T-cell recognition and neutralizing inhibitory molecules. Although immunotherapies based on these strategies have improved the clinical outcomes, immunological nonresponse and resistance are two barriers to tumor eradication. Therefore, there is an urgent need to identify new biomarkers for patient selection and therapeutic targets for the development of combination regimen with immunotherapy. Recent studies have reported that non-protein-coding modulators exhibit important functions in post-transcriptional gene regulation, which subsequently modulates multiple pathophysiological processes, including neoplastic transformation. Differentiated from microRNAs, long non-coding RNAs (lncRNAs) are reported to be involved in various processes of the immune response in the tumor microenvironment (TME) to promote tumor immunosuppression. Currently, studies on tumor immunity regulated by lncRNAs are mainly confined to certain types of cancer cells or stromal cells. Additionally, the majority of studies are focused on the events involved in T cells and myeloid-derived suppressor cells (MDSCs). Although the reported studies have indicated the significance of lncRNAs in immunotherapy, the lack of comprehensive studies prevents us from exploring useful lncRNAs. In the current review, we have summarized the roles of lncRNAs in tumor immune response, and highlighted major lncRNAs as potential biomarkers or therapeutic targets for clinical application of immunotherapy. |
| first_indexed | 2024-12-19T06:36:07Z |
| format | Article |
| id | doaj.art-91d4e4565868458483aaabaa20448d85 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T06:36:07Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-91d4e4565868458483aaabaa20448d852022-12-21T20:32:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-01-011010.3389/fonc.2020.00048500685Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor MicroenvironmentYa Luo0Jiqiao Yang1Jiqiao Yang2Jing Yu3Xiaowei Liu4Chune Yu5Jianping Hu6Hubing Shi7Xuelei Ma8Xuelei Ma9Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaLaboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaDepartment of Breast Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaLaboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaLaboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaCollege of Pharmacy and Biological Engineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, ChinaLaboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaLaboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, ChinaState Key Laboratory of Biotherapy, Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaTumor immunosuppression may assist the immune escape of cancer cells, which promotes tumor metastasis and resistance to chemo-radiotherapy. The therapeutic strategies against tumor immunosuppression mainly focus on blocking immune checkpoint receptors, enhancing T-cell recognition and neutralizing inhibitory molecules. Although immunotherapies based on these strategies have improved the clinical outcomes, immunological nonresponse and resistance are two barriers to tumor eradication. Therefore, there is an urgent need to identify new biomarkers for patient selection and therapeutic targets for the development of combination regimen with immunotherapy. Recent studies have reported that non-protein-coding modulators exhibit important functions in post-transcriptional gene regulation, which subsequently modulates multiple pathophysiological processes, including neoplastic transformation. Differentiated from microRNAs, long non-coding RNAs (lncRNAs) are reported to be involved in various processes of the immune response in the tumor microenvironment (TME) to promote tumor immunosuppression. Currently, studies on tumor immunity regulated by lncRNAs are mainly confined to certain types of cancer cells or stromal cells. Additionally, the majority of studies are focused on the events involved in T cells and myeloid-derived suppressor cells (MDSCs). Although the reported studies have indicated the significance of lncRNAs in immunotherapy, the lack of comprehensive studies prevents us from exploring useful lncRNAs. In the current review, we have summarized the roles of lncRNAs in tumor immune response, and highlighted major lncRNAs as potential biomarkers or therapeutic targets for clinical application of immunotherapy.https://www.frontiersin.org/article/10.3389/fonc.2020.00048/fullimmunosuppressionlong non-coding RNAtumor microenvironmentimmune responsetherapeutic targetbiomarker |
| spellingShingle | Ya Luo Jiqiao Yang Jiqiao Yang Jing Yu Xiaowei Liu Chune Yu Jianping Hu Hubing Shi Xuelei Ma Xuelei Ma Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment Frontiers in Oncology immunosuppression long non-coding RNA tumor microenvironment immune response therapeutic target biomarker |
| title | Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment |
| title_full | Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment |
| title_fullStr | Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment |
| title_full_unstemmed | Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment |
| title_short | Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment |
| title_sort | long non coding rnas emerging roles in the immunosuppressive tumor microenvironment |
| topic | immunosuppression long non-coding RNA tumor microenvironment immune response therapeutic target biomarker |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00048/full |
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