Spectrum of lymph node lesions as determined by histopathology
Background and Objective: Lymph node lesions form a wide range of spectrum, exhibiting manifestations in both hematopoietic tissue and lympho reticular system. It is necessary to document the same spectrum in a particular region to understand the trend and diseases occurring frequently in that regio...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Medical Journal of Dr. D.Y. Patil University |
| Subjects: | |
| Online Access: | http://www.mjdrdypu.org/article.asp?issn=0975-2870;year=2017;volume=10;issue=4;spage=343;epage=348;aulast=Pagaro |
| _version_ | 1828279825271357440 |
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| author | Pradhan M Pagaro Bedarshi Banerjee Anushree Khandelwal Aditi Pandey Anushree Gambhir |
| author_facet | Pradhan M Pagaro Bedarshi Banerjee Anushree Khandelwal Aditi Pandey Anushree Gambhir |
| author_sort | Pradhan M Pagaro |
| collection | DOAJ |
| description | Background and Objective: Lymph node lesions form a wide range of spectrum, exhibiting manifestations in both hematopoietic tissue and lympho reticular system. It is necessary to document the same spectrum in a particular region to understand the trend and diseases occurring frequently in that region. The range encompasses benign reactive changes to frank malignant lymphoma and metastatic deposits. Histopathology is considered to be the gold standard and its relevance to clinical diagnosis is studied here. Materials and Methods: A total of 200 cases were studied retrospectively in this study. Samples received were either biopsy or node resection specimens, and clinical history was recorded for each of them. Immunohistochemistry and special stains were performed as and when required. Results: Clinical diagnosis had a diagnostic accuracy of 71% approximately using histopathology as the gold standard. Most of the benign diseases were either reactive or tubercular lymphadenitis, whereas non-Hodgkin Follicular lymphoma had the maximum incidence among lymphomas. Conclusion: This study concluded that cervical group of superficial lymph nodes are most frequently encountered as palpable nodal swellings. The clinical suspicion of malignancy remains high in most of the cases due to the matted and enlarged presentation of lymph nodes. Histopathology revealed that only 33.5% of the cases to be malignant of which the most common was Follicular Lymphoma (non-Hodgkin type). The clinical accuracy of diagnosing malignant lesions thus coming to 71% approximately. |
| first_indexed | 2024-04-13T07:50:34Z |
| format | Article |
| id | doaj.art-91d63872d9ed4d399c3f20c7f99b8b32 |
| institution | Directory Open Access Journal |
| issn | 0975-2870 |
| language | English |
| last_indexed | 2024-04-13T07:50:34Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil University |
| spelling | doaj.art-91d63872d9ed4d399c3f20c7f99b8b322022-12-22T02:55:34ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil University0975-28702017-01-0110434334810.4103/MJDRDYPU.MJDRDYPU_296_16Spectrum of lymph node lesions as determined by histopathologyPradhan M PagaroBedarshi BanerjeeAnushree KhandelwalAditi PandeyAnushree GambhirBackground and Objective: Lymph node lesions form a wide range of spectrum, exhibiting manifestations in both hematopoietic tissue and lympho reticular system. It is necessary to document the same spectrum in a particular region to understand the trend and diseases occurring frequently in that region. The range encompasses benign reactive changes to frank malignant lymphoma and metastatic deposits. Histopathology is considered to be the gold standard and its relevance to clinical diagnosis is studied here. Materials and Methods: A total of 200 cases were studied retrospectively in this study. Samples received were either biopsy or node resection specimens, and clinical history was recorded for each of them. Immunohistochemistry and special stains were performed as and when required. Results: Clinical diagnosis had a diagnostic accuracy of 71% approximately using histopathology as the gold standard. Most of the benign diseases were either reactive or tubercular lymphadenitis, whereas non-Hodgkin Follicular lymphoma had the maximum incidence among lymphomas. Conclusion: This study concluded that cervical group of superficial lymph nodes are most frequently encountered as palpable nodal swellings. The clinical suspicion of malignancy remains high in most of the cases due to the matted and enlarged presentation of lymph nodes. Histopathology revealed that only 33.5% of the cases to be malignant of which the most common was Follicular Lymphoma (non-Hodgkin type). The clinical accuracy of diagnosing malignant lesions thus coming to 71% approximately.http://www.mjdrdypu.org/article.asp?issn=0975-2870;year=2017;volume=10;issue=4;spage=343;epage=348;aulast=PagaroClinico-pathological correlationhistopathological spectrumlymph nodeslymphoma |
| spellingShingle | Pradhan M Pagaro Bedarshi Banerjee Anushree Khandelwal Aditi Pandey Anushree Gambhir Spectrum of lymph node lesions as determined by histopathology Medical Journal of Dr. D.Y. Patil University Clinico-pathological correlation histopathological spectrum lymph nodes lymphoma |
| title | Spectrum of lymph node lesions as determined by histopathology |
| title_full | Spectrum of lymph node lesions as determined by histopathology |
| title_fullStr | Spectrum of lymph node lesions as determined by histopathology |
| title_full_unstemmed | Spectrum of lymph node lesions as determined by histopathology |
| title_short | Spectrum of lymph node lesions as determined by histopathology |
| title_sort | spectrum of lymph node lesions as determined by histopathology |
| topic | Clinico-pathological correlation histopathological spectrum lymph nodes lymphoma |
| url | http://www.mjdrdypu.org/article.asp?issn=0975-2870;year=2017;volume=10;issue=4;spage=343;epage=348;aulast=Pagaro |
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