Specific Features of Juvenile Idiopathic Arthritis Patients’ Cytokine Profile
Juvenile idiopathic arthritis (JIA) is a systemic autoimmune disease that affects the joints, leading to disability. Cytokines and signaling molecules expressed by the immune system cells play a key role in JIA pathogenesis. Understanding how their content changes during pathology development can op...
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MDPI AG
2024-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/1/135 |
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| author | Daria I. Kozlova Arseny V. Rybakov Karina A. Yureva Vitaly V. Khizha Lybov S. Sorokina Mikhail M. Kostik Alexandr B. Guslev |
| author_facet | Daria I. Kozlova Arseny V. Rybakov Karina A. Yureva Vitaly V. Khizha Lybov S. Sorokina Mikhail M. Kostik Alexandr B. Guslev |
| author_sort | Daria I. Kozlova |
| collection | DOAJ |
| description | Juvenile idiopathic arthritis (JIA) is a systemic autoimmune disease that affects the joints, leading to disability. Cytokines and signaling molecules expressed by the immune system cells play a key role in JIA pathogenesis. Understanding how their content changes during pathology development can open up new opportunities for its diagnosis and treatment. The blood plasma of 30 patients with JIA (14 males and 16 females with a mean age of 12.2 ± 4.1) and 20 relatively healthy individuals (10 males and 10 females with a mean age of 10.20 ± 5.85) was analyzed to determine the levels of cytokines using the MILLIPLEX<sup>®</sup> kit. An increase in interleukins (IL)-1α, 1β, 2, 4, 5, 6, 7, 8, 9, 10, 13, 15, 17F, 22, and 27 and a decrease in IL-3 levels have been shown in patients with JIA. Levels of cytokines, which are important for B-cell activation and proliferation, are increased, while levels of T-cell activating factors remained similar to the control group. Based on our results, it can be assumed that the use of combination therapy aimed at inhibiting both nonspecific interleukins and cytokines that activate B-cells will be more effective for the treatment of JIA. |
| first_indexed | 2024-03-08T09:57:01Z |
| format | Article |
| id | doaj.art-91d66c5dd6744834a1d79161169491b8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:57:01Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-91d66c5dd6744834a1d79161169491b82024-01-29T13:47:26ZengMDPI AGBiomedicines2227-90592024-01-0112113510.3390/biomedicines12010135Specific Features of Juvenile Idiopathic Arthritis Patients’ Cytokine ProfileDaria I. Kozlova0Arseny V. Rybakov1Karina A. Yureva2Vitaly V. Khizha3Lybov S. Sorokina4Mikhail M. Kostik5Alexandr B. Guslev6Saint-Petersburg Clinical Hospital of the Russian Academy of Sciences, Saint-Petersburg 194017, RussiaSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences (IEPhB RAS), Saint-Petersburg 194223, RussiaSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences (IEPhB RAS), Saint-Petersburg 194223, RussiaSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences (IEPhB RAS), Saint-Petersburg 194223, RussiaHospital Pediatry, Saint-Petersburg State Pediatric Medical University, Saint-Petersburg 194100, RussiaHospital Pediatry, Saint-Petersburg State Pediatric Medical University, Saint-Petersburg 194100, RussiaSaint-Petersburg Clinical Hospital of the Russian Academy of Sciences, Saint-Petersburg 194017, RussiaJuvenile idiopathic arthritis (JIA) is a systemic autoimmune disease that affects the joints, leading to disability. Cytokines and signaling molecules expressed by the immune system cells play a key role in JIA pathogenesis. Understanding how their content changes during pathology development can open up new opportunities for its diagnosis and treatment. The blood plasma of 30 patients with JIA (14 males and 16 females with a mean age of 12.2 ± 4.1) and 20 relatively healthy individuals (10 males and 10 females with a mean age of 10.20 ± 5.85) was analyzed to determine the levels of cytokines using the MILLIPLEX<sup>®</sup> kit. An increase in interleukins (IL)-1α, 1β, 2, 4, 5, 6, 7, 8, 9, 10, 13, 15, 17F, 22, and 27 and a decrease in IL-3 levels have been shown in patients with JIA. Levels of cytokines, which are important for B-cell activation and proliferation, are increased, while levels of T-cell activating factors remained similar to the control group. Based on our results, it can be assumed that the use of combination therapy aimed at inhibiting both nonspecific interleukins and cytokines that activate B-cells will be more effective for the treatment of JIA.https://www.mdpi.com/2227-9059/12/1/135juvenile idiopathic arthritiscytokinesbiomarkers |
| spellingShingle | Daria I. Kozlova Arseny V. Rybakov Karina A. Yureva Vitaly V. Khizha Lybov S. Sorokina Mikhail M. Kostik Alexandr B. Guslev Specific Features of Juvenile Idiopathic Arthritis Patients’ Cytokine Profile Biomedicines juvenile idiopathic arthritis cytokines biomarkers |
| title | Specific Features of Juvenile Idiopathic Arthritis Patients’ Cytokine Profile |
| title_full | Specific Features of Juvenile Idiopathic Arthritis Patients’ Cytokine Profile |
| title_fullStr | Specific Features of Juvenile Idiopathic Arthritis Patients’ Cytokine Profile |
| title_full_unstemmed | Specific Features of Juvenile Idiopathic Arthritis Patients’ Cytokine Profile |
| title_short | Specific Features of Juvenile Idiopathic Arthritis Patients’ Cytokine Profile |
| title_sort | specific features of juvenile idiopathic arthritis patients cytokine profile |
| topic | juvenile idiopathic arthritis cytokines biomarkers |
| url | https://www.mdpi.com/2227-9059/12/1/135 |
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