ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan
<p>Abstract</p> <p>Background</p> <p>Understanding the pathogenesis of malaria in pregnancy and its consequences for both the mother and the baby is fundamental for improving malaria control in pregnant women.</p> <p>Aim</p> <p>The study aimed to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2007-08-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/6/1/110 |
| _version_ | 1818556483158147072 |
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| author | Prins Martin H Salih Magdi M Mohmmed Ahmed A Babiker Saud Adam Ishag Zaki Zaki M |
| author_facet | Prins Martin H Salih Magdi M Mohmmed Ahmed A Babiker Saud Adam Ishag Zaki Zaki M |
| author_sort | Prins Martin H |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Understanding the pathogenesis of malaria in pregnancy and its consequences for both the mother and the baby is fundamental for improving malaria control in pregnant women.</p> <p>Aim</p> <p>The study aimed to investigate the role of ABO blood groups on pregnancy outcomes in an area of unstable malaria transmission in eastern Sudan.</p> <p>Methods</p> <p>A total of 293 women delivering in New Half teaching hospital, eastern Sudan during the period October 2006–March 2007 have been analyzed. ABO blood groups were determined and placental histopathology examinations for malaria were performed. Birth and placental weight were recorded and maternal haemoglobin was measured.</p> <p>Results</p> <p>114 (39.7%), 61 (22.1%) and 118 (38.2%) women were primiparae, secundiparae and multiparae, respectively. The ABO blood group distribution was 82(A), 59 (B), 24 (AB) and 128 (O). Placental histopathology showed acute placental malaria infections in 6 (2%), chronic infections in 6 (2%), 82 (28.0%) of the placentae showed past infection and 199 (68.0%) showed no infection. There was no association between the age (OR = 1.02, 95% CI = 0.45–2.2; <it>P </it>= 0.9), parity (OR = 0.6, 95% CI = 0.3–1.2; <it>P </it>= 0.1) and placental malaria infections. In all parity blood group O was associated with a higher risk of past (OR = 1.9, 95% CI = 1.1–3.2; <it>P </it>= 0.01) placental malaria infection. This was also true when primiparae were considered separately (OR = 2.6, 95% CI = 1.05–6.5, <it>P </it>= 0.03).</p> <p>Among women with all placental infections/past placental infection, the mean haemoglobin was higher in women with the blood group O, but the mean birth weight, foeto-placental weight ratio was not different between these groups and the non-O group.</p> <p>Conclusion</p> <p>These results indicate that women of eastern Sudan are at risk for placental malaria infection irrespective to their age or parity. Those women with blood group O were at higher risk of past placental malaria infection.</p> |
| first_indexed | 2024-12-13T23:47:55Z |
| format | Article |
| id | doaj.art-91d6d3fb3043431a9eed84fe8edbd225 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-13T23:47:55Z |
| publishDate | 2007-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-91d6d3fb3043431a9eed84fe8edbd2252022-12-21T23:26:53ZengBMCMalaria Journal1475-28752007-08-016111010.1186/1475-2875-6-110ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern SudanPrins Martin HSalih Magdi MMohmmed Ahmed ABabiker SaudAdam IshagZaki Zaki M<p>Abstract</p> <p>Background</p> <p>Understanding the pathogenesis of malaria in pregnancy and its consequences for both the mother and the baby is fundamental for improving malaria control in pregnant women.</p> <p>Aim</p> <p>The study aimed to investigate the role of ABO blood groups on pregnancy outcomes in an area of unstable malaria transmission in eastern Sudan.</p> <p>Methods</p> <p>A total of 293 women delivering in New Half teaching hospital, eastern Sudan during the period October 2006–March 2007 have been analyzed. ABO blood groups were determined and placental histopathology examinations for malaria were performed. Birth and placental weight were recorded and maternal haemoglobin was measured.</p> <p>Results</p> <p>114 (39.7%), 61 (22.1%) and 118 (38.2%) women were primiparae, secundiparae and multiparae, respectively. The ABO blood group distribution was 82(A), 59 (B), 24 (AB) and 128 (O). Placental histopathology showed acute placental malaria infections in 6 (2%), chronic infections in 6 (2%), 82 (28.0%) of the placentae showed past infection and 199 (68.0%) showed no infection. There was no association between the age (OR = 1.02, 95% CI = 0.45–2.2; <it>P </it>= 0.9), parity (OR = 0.6, 95% CI = 0.3–1.2; <it>P </it>= 0.1) and placental malaria infections. In all parity blood group O was associated with a higher risk of past (OR = 1.9, 95% CI = 1.1–3.2; <it>P </it>= 0.01) placental malaria infection. This was also true when primiparae were considered separately (OR = 2.6, 95% CI = 1.05–6.5, <it>P </it>= 0.03).</p> <p>Among women with all placental infections/past placental infection, the mean haemoglobin was higher in women with the blood group O, but the mean birth weight, foeto-placental weight ratio was not different between these groups and the non-O group.</p> <p>Conclusion</p> <p>These results indicate that women of eastern Sudan are at risk for placental malaria infection irrespective to their age or parity. Those women with blood group O were at higher risk of past placental malaria infection.</p>http://www.malariajournal.com/content/6/1/110 |
| spellingShingle | Prins Martin H Salih Magdi M Mohmmed Ahmed A Babiker Saud Adam Ishag Zaki Zaki M ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan Malaria Journal |
| title | ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
| title_full | ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
| title_fullStr | ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
| title_full_unstemmed | ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
| title_short | ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan |
| title_sort | abo blood group system and placental malaria in an area of unstable malaria transmission in eastern sudan |
| url | http://www.malariajournal.com/content/6/1/110 |
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