Alterations in macrophage polarization play a key role in control and development of periodontal diseases
Periodontitis is a chronic inflammatory disease driven by complex interplays between a dysbiotic oral microbiome and a dysregulated host inflammatory response that results in the destruction of the tooth-supporting apparatus. Among the inflammatory cells involved in the pathogenesis of periodontitis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Indian Society of Periodontology |
| Subjects: | |
| Online Access: | http://www.jisponline.com/article.asp?issn=0972-124X;year=2023;volume=27;issue=6;spage=578;epage=582;aulast=Sloniak |
| _version_ | 1797246254189641728 |
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| author | Mariane Cristina Sloniak Ana Paula Lepique Laís Yumi Souza Nakao Cristina Cunha Villar |
| author_facet | Mariane Cristina Sloniak Ana Paula Lepique Laís Yumi Souza Nakao Cristina Cunha Villar |
| author_sort | Mariane Cristina Sloniak |
| collection | DOAJ |
| description | Periodontitis is a chronic inflammatory disease driven by complex interplays between a dysbiotic oral microbiome and a dysregulated host inflammatory response that results in the destruction of the tooth-supporting apparatus. Among the inflammatory cells involved in the pathogenesis of periodontitis, macrophages are recruited early on to sites of periodontal infection. These cells can polarize in different phenotypes that mediate the initiation and resolution of inflammatory responses, as well as in tissue healing. Macrophage phenotypic plasticity is thought to play a critical role in the induction and resolution of inflammation and may be compromised in patients with chronic inflammatory diseases. Here, we reviewed the role of macrophage polarization in periodontal disease and therapy. |
| first_indexed | 2024-04-24T19:39:52Z |
| format | Article |
| id | doaj.art-91d72825a2bb40a78d839513718512c2 |
| institution | Directory Open Access Journal |
| issn | 0972-124X |
| language | English |
| last_indexed | 2024-04-24T19:39:52Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Society of Periodontology |
| spelling | doaj.art-91d72825a2bb40a78d839513718512c22024-03-25T11:17:25ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X2023-01-0127657858210.4103/jisp.jisp_75_23Alterations in macrophage polarization play a key role in control and development of periodontal diseasesMariane Cristina SloniakAna Paula LepiqueLaís Yumi Souza NakaoCristina Cunha VillarPeriodontitis is a chronic inflammatory disease driven by complex interplays between a dysbiotic oral microbiome and a dysregulated host inflammatory response that results in the destruction of the tooth-supporting apparatus. Among the inflammatory cells involved in the pathogenesis of periodontitis, macrophages are recruited early on to sites of periodontal infection. These cells can polarize in different phenotypes that mediate the initiation and resolution of inflammatory responses, as well as in tissue healing. Macrophage phenotypic plasticity is thought to play a critical role in the induction and resolution of inflammation and may be compromised in patients with chronic inflammatory diseases. Here, we reviewed the role of macrophage polarization in periodontal disease and therapy.http://www.jisponline.com/article.asp?issn=0972-124X;year=2023;volume=27;issue=6;spage=578;epage=582;aulast=Sloniakgingivitisimmunomodulationinflammationmacrophagesperiodontitis |
| spellingShingle | Mariane Cristina Sloniak Ana Paula Lepique Laís Yumi Souza Nakao Cristina Cunha Villar Alterations in macrophage polarization play a key role in control and development of periodontal diseases Journal of Indian Society of Periodontology gingivitis immunomodulation inflammation macrophages periodontitis |
| title | Alterations in macrophage polarization play a key role in control and development of periodontal diseases |
| title_full | Alterations in macrophage polarization play a key role in control and development of periodontal diseases |
| title_fullStr | Alterations in macrophage polarization play a key role in control and development of periodontal diseases |
| title_full_unstemmed | Alterations in macrophage polarization play a key role in control and development of periodontal diseases |
| title_short | Alterations in macrophage polarization play a key role in control and development of periodontal diseases |
| title_sort | alterations in macrophage polarization play a key role in control and development of periodontal diseases |
| topic | gingivitis immunomodulation inflammation macrophages periodontitis |
| url | http://www.jisponline.com/article.asp?issn=0972-124X;year=2023;volume=27;issue=6;spage=578;epage=582;aulast=Sloniak |
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