Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial Detachment
The aim of this study was to report unusual progression of type 2 macular neovascularization (MNV) associated with age-related macular degeneration (AMD), high myopia or angioid streaks. Retrospective multicentric observational case series data were used. Eyes that progressed from type 2 MNV seconda...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Vision |
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| Online Access: | https://www.mdpi.com/2411-5150/5/2/16 |
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| author | Hoang Mai LE Gérard Mimoun Salomon Y. Cohen Camille Jung Oudy Semoun Eric H. Souied |
| author_facet | Hoang Mai LE Gérard Mimoun Salomon Y. Cohen Camille Jung Oudy Semoun Eric H. Souied |
| author_sort | Hoang Mai LE |
| collection | DOAJ |
| description | The aim of this study was to report unusual progression of type 2 macular neovascularization (MNV) associated with age-related macular degeneration (AMD), high myopia or angioid streaks. Retrospective multicentric observational case series data were used. Eyes that progressed from type 2 MNV secondary to AMD, high myopia or angioid streaks to fibrovascular pigment epithelial detachment (PED) were included. A total of 29 treatment-naive eyes from 29 patients with type 2 MNV secondary to AMD (<i>n</i> = 14), high myopia (<i>n</i> = 10) or angioid streaks (<i>n</i> = 5) that progressed to a fibrovascular PED on Spectral Domain-Optical Coherence Tomography were used. This progression occurred within 3 months after anti-VEGF therapy initiation. Logarithm of minimum angle of resolution (LogMAR) visual acuity improved significantly after anti-VEGF therapy, from 0.55 (SD ± 0.30) (20/63–20/80) at baseline to 0.30 (20/40) at 3 months, and 0.33 (20/40) at the final follow-up (mean follow up: 3.68 years). Mean number of intravitreal injections per year for patients with a total follow-up ≥ 12 months (<i>n</i> = 24) was 4.3 ± 2.1 per year. Progression from type 2 MNV to a fibrovascular PED may occur in patients suffering from AMD, high myopia or angioid streaks. This progression appears early after initiation of anti-VEGF therapy and is associated with a favorable visual and anatomical outcome, at least on a short follow up basis. |
| first_indexed | 2024-03-10T12:56:17Z |
| format | Article |
| id | doaj.art-91d7d120fd6a40448679ee86db0111a9 |
| institution | Directory Open Access Journal |
| issn | 2411-5150 |
| language | English |
| last_indexed | 2024-03-10T12:56:17Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vision |
| spelling | doaj.art-91d7d120fd6a40448679ee86db0111a92023-11-21T11:55:37ZengMDPI AGVision2411-51502021-03-01521610.3390/vision5020016Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial DetachmentHoang Mai LE0Gérard Mimoun1Salomon Y. Cohen2Camille Jung3Oudy Semoun4Eric H. Souied5Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil and University Paris Est, 94000 Créteil, FranceDepartment of Ophthalmology, Centre Hospitalier Intercommunal de Créteil and University Paris Est, 94000 Créteil, FranceDepartment of Ophthalmology, Centre Hospitalier Intercommunal de Créteil and University Paris Est, 94000 Créteil, FranceCentre de Recherche Clinique-Centre de Ressources Biologiques, Intercity Hospital, 94000 Créteil, FranceDepartment of Ophthalmology, Centre Hospitalier Intercommunal de Créteil and University Paris Est, 94000 Créteil, FranceDepartment of Ophthalmology, Centre Hospitalier Intercommunal de Créteil and University Paris Est, 94000 Créteil, FranceThe aim of this study was to report unusual progression of type 2 macular neovascularization (MNV) associated with age-related macular degeneration (AMD), high myopia or angioid streaks. Retrospective multicentric observational case series data were used. Eyes that progressed from type 2 MNV secondary to AMD, high myopia or angioid streaks to fibrovascular pigment epithelial detachment (PED) were included. A total of 29 treatment-naive eyes from 29 patients with type 2 MNV secondary to AMD (<i>n</i> = 14), high myopia (<i>n</i> = 10) or angioid streaks (<i>n</i> = 5) that progressed to a fibrovascular PED on Spectral Domain-Optical Coherence Tomography were used. This progression occurred within 3 months after anti-VEGF therapy initiation. Logarithm of minimum angle of resolution (LogMAR) visual acuity improved significantly after anti-VEGF therapy, from 0.55 (SD ± 0.30) (20/63–20/80) at baseline to 0.30 (20/40) at 3 months, and 0.33 (20/40) at the final follow-up (mean follow up: 3.68 years). Mean number of intravitreal injections per year for patients with a total follow-up ≥ 12 months (<i>n</i> = 24) was 4.3 ± 2.1 per year. Progression from type 2 MNV to a fibrovascular PED may occur in patients suffering from AMD, high myopia or angioid streaks. This progression appears early after initiation of anti-VEGF therapy and is associated with a favorable visual and anatomical outcome, at least on a short follow up basis.https://www.mdpi.com/2411-5150/5/2/16age-related macular degenerationangioid streaksfibrosisfibrovascular pigment epithelial detachmentmacular neovascularizationmyopia |
| spellingShingle | Hoang Mai LE Gérard Mimoun Salomon Y. Cohen Camille Jung Oudy Semoun Eric H. Souied Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial Detachment Vision age-related macular degeneration angioid streaks fibrosis fibrovascular pigment epithelial detachment macular neovascularization myopia |
| title | Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial Detachment |
| title_full | Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial Detachment |
| title_fullStr | Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial Detachment |
| title_full_unstemmed | Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial Detachment |
| title_short | Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial Detachment |
| title_sort | progression from type 2 macular neovascularization to fibrovascular pigment epithelial detachment |
| topic | age-related macular degeneration angioid streaks fibrosis fibrovascular pigment epithelial detachment macular neovascularization myopia |
| url | https://www.mdpi.com/2411-5150/5/2/16 |
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