Apolipoprotein E Deficiency Exacerbates Spinal Cord Injury in Mice: Inflammatory Response and Oxidative Stress Mediated by NF-κB Signaling Pathway

Apolipoprotein E Deficiency Exacerbates Spinal Cord Injury in Mice: Inflammatory Response and Oxidative Stress Mediated by NF-κB Signaling Pathway

Spinal cord injury (SCI) is a severe neurological trauma that involves complex pathological processes. Inflammatory response and oxidative stress are prevalent during the second injury and can influence the functional recovery of SCI. Specially, Apolipoprotein E (APOE) induces neuronal repair and ne...

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Bibliographic Details
Main Authors: Xuan Yang, Shurui Chen, Zhenya Shao, Yuanlong Li, He Wu, Xian Li, Liang Mao, Zipeng Zhou, Liangjie Bai, Xifan Mei, Chang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
contusive spinal cord injury
Apolipoprotein E
neuroinflammation
oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00142/full

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