Biomarkers of aging-associated chronic inflammation as a prognostic factor for human longevity
It has been well-established that age-associated low-grade chronic inflammation contributes to the development of a spectrum of chronic diseases, including diabetes mellitus, ischemic heart disease, stroke, cancer, chronic kidney disease, non-alcoholic fatty liver disease and neurodegenerative disea...
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2022-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2022/0004-19632202091L.pdf |
| _version_ | 1818246264451497984 |
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| author | Leposavić Gordana Stojić-Vukanić Zorica |
| author_facet | Leposavić Gordana Stojić-Vukanić Zorica |
| author_sort | Leposavić Gordana |
| collection | DOAJ |
| description | It has been well-established that age-associated low-grade chronic inflammation contributes to the development of a spectrum of chronic diseases, including diabetes mellitus, ischemic heart disease, stroke, cancer, chronic kidney disease, non-alcoholic fatty liver disease and neurodegenerative diseases, which affect the quality of life of the elderly and influence their life span. This phenomenon is suggested to arise due to the weakening of the regulatory mechanisms of the immune response, and the persistence of exogenous and endogenous (reflecting oxidative cell injury) antigenic challenges, so it is referred to as oxi-inflamm-aging. Considering that the development of age-associated chronic inflammation is "silent", i.e., without clinical signs until the aforementioned complications become apparent, it is important to identify the biomarker(s) or pattern/cluster of biomarkers for this inflammation. It is also important to define new strategies to combat the "silent" damage induced by chronic inflammation. Given that at present there are no reliable biomarkers for chronic inflammation, this review points out the problems in defining biomarker(s) or patterns/clusters of biomarkers for chronic inflammation in order to stimulate further research and points to some possible routes of investigation. |
| first_indexed | 2024-12-12T14:46:03Z |
| format | Article |
| id | doaj.art-91dd423251144607b6db21de0e1e78a5 |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-12-12T14:46:03Z |
| publishDate | 2022-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-91dd423251144607b6db21de0e1e78a52022-12-22T00:21:06ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672022-01-017229110410.5937/arhfarm72-361350004-19632202091LBiomarkers of aging-associated chronic inflammation as a prognostic factor for human longevityLeposavić Gordana0https://orcid.org/0000-0002-1341-7716Stojić-Vukanić Zorica1https://orcid.org/0000-0001-5306-0523University of Belgrade, Faculty of Pharmacy, Department of Pathobiology, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Microbiology and Immunology, SerbiaIt has been well-established that age-associated low-grade chronic inflammation contributes to the development of a spectrum of chronic diseases, including diabetes mellitus, ischemic heart disease, stroke, cancer, chronic kidney disease, non-alcoholic fatty liver disease and neurodegenerative diseases, which affect the quality of life of the elderly and influence their life span. This phenomenon is suggested to arise due to the weakening of the regulatory mechanisms of the immune response, and the persistence of exogenous and endogenous (reflecting oxidative cell injury) antigenic challenges, so it is referred to as oxi-inflamm-aging. Considering that the development of age-associated chronic inflammation is "silent", i.e., without clinical signs until the aforementioned complications become apparent, it is important to identify the biomarker(s) or pattern/cluster of biomarkers for this inflammation. It is also important to define new strategies to combat the "silent" damage induced by chronic inflammation. Given that at present there are no reliable biomarkers for chronic inflammation, this review points out the problems in defining biomarker(s) or patterns/clusters of biomarkers for chronic inflammation in order to stimulate further research and points to some possible routes of investigation.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2022/0004-19632202091L.pdflongevitylow-grade chronic inflammationnon-communicable diseasesoxi-inflamm-agingbiomarkers of chronic inflammation |
| spellingShingle | Leposavić Gordana Stojić-Vukanić Zorica Biomarkers of aging-associated chronic inflammation as a prognostic factor for human longevity Arhiv za farmaciju longevity low-grade chronic inflammation non-communicable diseases oxi-inflamm-aging biomarkers of chronic inflammation |
| title | Biomarkers of aging-associated chronic inflammation as a prognostic factor for human longevity |
| title_full | Biomarkers of aging-associated chronic inflammation as a prognostic factor for human longevity |
| title_fullStr | Biomarkers of aging-associated chronic inflammation as a prognostic factor for human longevity |
| title_full_unstemmed | Biomarkers of aging-associated chronic inflammation as a prognostic factor for human longevity |
| title_short | Biomarkers of aging-associated chronic inflammation as a prognostic factor for human longevity |
| title_sort | biomarkers of aging associated chronic inflammation as a prognostic factor for human longevity |
| topic | longevity low-grade chronic inflammation non-communicable diseases oxi-inflamm-aging biomarkers of chronic inflammation |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2022/0004-19632202091L.pdf |
| work_keys_str_mv | AT leposavicgordana biomarkersofagingassociatedchronicinflammationasaprognosticfactorforhumanlongevity AT stojicvukaniczorica biomarkersofagingassociatedchronicinflammationasaprognosticfactorforhumanlongevity |