Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot Program
The prevalence of Sickle Cell Disease (SCD) within the Caribbean region remains second only to that of West Africa. The Newborn Screening (NBS) Program in Antigua and Barbuda remains heavily dependent on grants, therefore ultimately facing sustainability challenges. Early intervention and implementa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | International Journal of Neonatal Screening |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2409-515X/9/1/14 |
| _version_ | 1797611180175392768 |
|---|---|
| author | Shivon Belle Jarvis Edda Hadeed Ketty Lee Marie-Dominique Hardy-Dessources Jennifer M. Knight-Madden Claudine Richardson |
| author_facet | Shivon Belle Jarvis Edda Hadeed Ketty Lee Marie-Dominique Hardy-Dessources Jennifer M. Knight-Madden Claudine Richardson |
| author_sort | Shivon Belle Jarvis |
| collection | DOAJ |
| description | The prevalence of Sickle Cell Disease (SCD) within the Caribbean region remains second only to that of West Africa. The Newborn Screening (NBS) Program in Antigua and Barbuda remains heavily dependent on grants, therefore ultimately facing sustainability challenges. Early intervention and implementation of preventative measures post-NBS result in significant improvements in morbidity, quality of life, and survival. This audit reviewed the pilot SCD NBS Program in Antigua and Barbuda from September 2020 to December 2021. A conclusive result was received by 99% of babies eligible for screening, 84.3% of which were HbFA, whilst 9.6% and 4.6% were HbFAS and HbFAC, respectively. This was comparable to other Caribbean countries. Sickle Cell Disease was noted in 0.5% of babies screened, which translates to 1 in 222 live births. Eighty-two percent of mothers were aware of their sickle cell status, compared to 3% of fathers. The importance of instituting a quality improvement team post the initiation of a screening program and the need for a robust public education program have been demonstrated by this audit. |
| first_indexed | 2024-03-11T06:24:12Z |
| format | Article |
| id | doaj.art-91dd68efa7f34852bda5c5d36dea361b |
| institution | Directory Open Access Journal |
| issn | 2409-515X |
| language | English |
| last_indexed | 2024-03-11T06:24:12Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Neonatal Screening |
| spelling | doaj.art-91dd68efa7f34852bda5c5d36dea361b2023-11-17T11:42:30ZengMDPI AGInternational Journal of Neonatal Screening2409-515X2023-03-01911410.3390/ijns9010014Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot ProgramShivon Belle Jarvis0Edda Hadeed1Ketty Lee2Marie-Dominique Hardy-Dessources3Jennifer M. Knight-Madden4Claudine Richardson5Paediatric Department, Sir Lester Bird Medical Centre, Michael’s Mount, St. John’s, Antigua and BarbudaGambles Medical Centre, Friars Hill Road, St. John’s, Antigua and BarbudaLaboratory of Molecular Genetics and Inherited Disorders of Red Blood Cell, University Hospital of Guadeloupe, Guadeloupe, F.W.I, FranceUniversité des Antilles, UFR Médecine/Campus de Fouillolle-Université Paris Cité, Inserm, BIGR, 97159 Pointe-à-Pitre, FranceCaribbean Institute for Health Research-Sickle Cell Unit, The University of the West Indies, Mona, Kingston 7, JamaicaPaediatric Department, Sir Lester Bird Medical Centre, Michael’s Mount, St. John’s, Antigua and BarbudaThe prevalence of Sickle Cell Disease (SCD) within the Caribbean region remains second only to that of West Africa. The Newborn Screening (NBS) Program in Antigua and Barbuda remains heavily dependent on grants, therefore ultimately facing sustainability challenges. Early intervention and implementation of preventative measures post-NBS result in significant improvements in morbidity, quality of life, and survival. This audit reviewed the pilot SCD NBS Program in Antigua and Barbuda from September 2020 to December 2021. A conclusive result was received by 99% of babies eligible for screening, 84.3% of which were HbFA, whilst 9.6% and 4.6% were HbFAS and HbFAC, respectively. This was comparable to other Caribbean countries. Sickle Cell Disease was noted in 0.5% of babies screened, which translates to 1 in 222 live births. Eighty-two percent of mothers were aware of their sickle cell status, compared to 3% of fathers. The importance of instituting a quality improvement team post the initiation of a screening program and the need for a robust public education program have been demonstrated by this audit.https://www.mdpi.com/2409-515X/9/1/14sickle cell diseasenewborn screeningauditAntigua and Barbuda |
| spellingShingle | Shivon Belle Jarvis Edda Hadeed Ketty Lee Marie-Dominique Hardy-Dessources Jennifer M. Knight-Madden Claudine Richardson Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot Program International Journal of Neonatal Screening sickle cell disease newborn screening audit Antigua and Barbuda |
| title | Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot Program |
| title_full | Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot Program |
| title_fullStr | Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot Program |
| title_full_unstemmed | Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot Program |
| title_short | Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot Program |
| title_sort | sickle cell disease newborn screening an audit of a twin island state pilot program |
| topic | sickle cell disease newborn screening audit Antigua and Barbuda |
| url | https://www.mdpi.com/2409-515X/9/1/14 |
| work_keys_str_mv | AT shivonbellejarvis sicklecelldiseasenewbornscreeninganauditofatwinislandstatepilotprogram AT eddahadeed sicklecelldiseasenewbornscreeninganauditofatwinislandstatepilotprogram AT kettylee sicklecelldiseasenewbornscreeninganauditofatwinislandstatepilotprogram AT mariedominiquehardydessources sicklecelldiseasenewbornscreeninganauditofatwinislandstatepilotprogram AT jennifermknightmadden sicklecelldiseasenewbornscreeninganauditofatwinislandstatepilotprogram AT claudinerichardson sicklecelldiseasenewbornscreeninganauditofatwinislandstatepilotprogram |