Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy
Current therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we invest...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01384/full |
| _version_ | 1811280546733490176 |
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| author | Yimiao Sang Yimiao Sang Xiaohong Gu Lulu Pan Lulu Pan Chunxiang Zhang Chunxiang Zhang Xing Rong Tingting Wu Tianhe Xia Yuechun Li Lisha Ge Yuanhai Zhang Maoping Chu |
| author_facet | Yimiao Sang Yimiao Sang Xiaohong Gu Lulu Pan Lulu Pan Chunxiang Zhang Chunxiang Zhang Xing Rong Tingting Wu Tianhe Xia Yuechun Li Lisha Ge Yuanhai Zhang Maoping Chu |
| author_sort | Yimiao Sang |
| collection | DOAJ |
| description | Current therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we investigated the protective effect of MLT on viral myocarditis in a mouse model of myocarditis infected with coxsackievirus B3 (CVB3) and explored the probable mechanisms. Mice with CVB3-induced myocarditis displayed inflammatory cell infiltration and interstitial edema. MLT treatment significantly ameliorated the myocardial injuries. In addition, the rate of autophagy changed, although apoptosis was inhibited in mouse hearts following treatment with MLT. These results suggest that MLT has a strong therapeutic effect on acute viral myocarditis, which is associated with changes in autophagy and apoptosis in the heart. Thus, MLT could be a promising novel therapeutic approach against viral myocarditis. |
| first_indexed | 2024-04-13T01:16:44Z |
| format | Article |
| id | doaj.art-91dd6bd4dfd04589aff529861785fb7b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T01:16:44Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-91dd6bd4dfd04589aff529861785fb7b2022-12-22T03:08:54ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-12-01910.3389/fphar.2018.01384375656Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and AutophagyYimiao Sang0Yimiao Sang1Xiaohong Gu2Lulu Pan3Lulu Pan4Chunxiang Zhang5Chunxiang Zhang6Xing Rong7Tingting Wu8Tianhe Xia9Yuechun Li10Lisha Ge11Yuanhai Zhang12Maoping Chu13Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhejiang University, Hangzhou, ChinaChildren’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaChildren’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaChild Health Manage Department, Maternal and Child Health Care Institution, Wenzhou, ChinaChildren’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaDepartment of Biomedical Engineering, School of Medicine and School of Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesChildren’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaChildren’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaChildren’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaChildren’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaChildren’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, ChinaCurrent therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we investigated the protective effect of MLT on viral myocarditis in a mouse model of myocarditis infected with coxsackievirus B3 (CVB3) and explored the probable mechanisms. Mice with CVB3-induced myocarditis displayed inflammatory cell infiltration and interstitial edema. MLT treatment significantly ameliorated the myocardial injuries. In addition, the rate of autophagy changed, although apoptosis was inhibited in mouse hearts following treatment with MLT. These results suggest that MLT has a strong therapeutic effect on acute viral myocarditis, which is associated with changes in autophagy and apoptosis in the heart. Thus, MLT could be a promising novel therapeutic approach against viral myocarditis.https://www.frontiersin.org/article/10.3389/fphar.2018.01384/fullmyocarditismelatoninautophagyapoptosiscoxsackievirus B3 |
| spellingShingle | Yimiao Sang Yimiao Sang Xiaohong Gu Lulu Pan Lulu Pan Chunxiang Zhang Chunxiang Zhang Xing Rong Tingting Wu Tianhe Xia Yuechun Li Lisha Ge Yuanhai Zhang Maoping Chu Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy Frontiers in Pharmacology myocarditis melatonin autophagy apoptosis coxsackievirus B3 |
| title | Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy |
| title_full | Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy |
| title_fullStr | Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy |
| title_full_unstemmed | Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy |
| title_short | Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy |
| title_sort | melatonin ameliorates coxsackievirus b3 induced myocarditis by regulating apoptosis and autophagy |
| topic | myocarditis melatonin autophagy apoptosis coxsackievirus B3 |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01384/full |
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