Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects
Background: Cardiovascular malformations account for nearly one-third of all congenital anomalies, making these the most common type of birth defects. Little is known regarding the influence of ambient ultrafine particles (<0.1 μm) (UFPs) on their occurrence. Objective: This population-based stud...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019311080 |
| _version_ | 1819225776744038400 |
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| author | Eric Lavigne Isac Lima Marianne Hatzopoulou Keith Van Ryswyk Mary Lou Decou Wei Luo Aaron van Donkelaar Randall V. Martin Hong Chen David M. Stieb Eric Crighton Antonio Gasparrini Michael Elten Abdool S. Yasseen, III Richard T. Burnett Mark Walker Scott Weichenthal |
| author_facet | Eric Lavigne Isac Lima Marianne Hatzopoulou Keith Van Ryswyk Mary Lou Decou Wei Luo Aaron van Donkelaar Randall V. Martin Hong Chen David M. Stieb Eric Crighton Antonio Gasparrini Michael Elten Abdool S. Yasseen, III Richard T. Burnett Mark Walker Scott Weichenthal |
| author_sort | Eric Lavigne |
| collection | DOAJ |
| description | Background: Cardiovascular malformations account for nearly one-third of all congenital anomalies, making these the most common type of birth defects. Little is known regarding the influence of ambient ultrafine particles (<0.1 μm) (UFPs) on their occurrence. Objective: This population-based study examined the association between prenatal exposure to UFPs and congenital heart defects (CHDs). Methods: A total of 158,743 singleton live births occurring in the City of Toronto, Canada between April 1st 2006 and March 31st 2012 were identified from a birth registry. Associations between exposure to ambient UFPs between the 2nd and 8th week post conception when the foetal heart begins to form and CHDs identified at birth were estimated using random-effects logistic regression models, adjusting for personal- and neighbourhood-level covariates. We also investigated multi-pollutant models accounting for co-exposures to PM2.5, NO2 and O3. Results: A total of 1468 CHDs were identified. In fully adjusted models, UFP exposures during weeks 2 to 8 of pregnancy were not associated with overall CHDs (Odds Ratio (OR) per interquartile (IQR) increase = 1.02, 95% CI: 0.96–1.08). When investigating subtypes of CHDs, UFP exposures were associated with ventricular septal defects (Odds Ratio (OR) per interquartile (IQR) increase = 1.13, 95% CI: 1.03–1.33), but not with atrial septal defect (Odds Ratio (OR) per interquartile (IQR) increase = 0.89, 95% CI: 0.74–1.06). Conclusion: This is the first study to evaluate the association between prenatal exposure to UFPs and the risk of CHDs. UFP exposures during a critical period of embryogenesis were associated with an increased risk of ventricular septal defect. Keywords: Ultrafine particle, Air pollution, Prenatal, Congenital heart defect |
| first_indexed | 2024-12-23T10:14:59Z |
| format | Article |
| id | doaj.art-91de4f78b9114d8c9dcbd41eabbce2e1 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-23T10:14:59Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-91de4f78b9114d8c9dcbd41eabbce2e12022-12-21T17:50:50ZengElsevierEnvironment International0160-41202019-09-01130Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defectsEric Lavigne0Isac Lima1Marianne Hatzopoulou2Keith Van Ryswyk3Mary Lou Decou4Wei Luo5Aaron van Donkelaar6Randall V. Martin7Hong Chen8David M. Stieb9Eric Crighton10Antonio Gasparrini11Michael Elten12Abdool S. Yasseen, III13Richard T. Burnett14Mark Walker15Scott Weichenthal16Air Health Science Division, Health Canada, Ottawa, Ontario, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada; Corresponding author at: Air Health Science Division, Health Canada, 269 Laurier Avenue West, Mail stop 4903B, Ottawa, Ontario K1A 0K9, Canada.Institute for Clinical Evaluative Sciences, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaDepartment of Civil Engineering, University of Toronto, Toronto, Ontario, CanadaAir Health Science Division, Health Canada, Ottawa, Ontario, CanadaMaternal & Infant Health Section, Public Health Agency of Canada, Ottawa, Ontario, CanadaMaternal & Infant Health Section, Public Health Agency of Canada, Ottawa, Ontario, CanadaDepartment of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, CanadaDepartment of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada; Harvard-Smithsonian Centre for Astrophysics, Cambridge, MA, USAPopulation Studies Division, Health Canada, Ottawa, Ontario, Canada; Public Health Ontario, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, CanadaSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada; Population Studies Division, Health Canada, Vancouver, British Columbia, CanadaInstitute for Clinical Evaluative Sciences, Ottawa, Ontario, Canada; Department of Geography, Environment and Geomatics, University of Ottawa, Ottawa, Ontario, CanadaDepartment of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, UKAir Health Science Division, Health Canada, Ottawa, Ontario, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, CanadaBetter Outcomes Registry and Network Ontario, Ottawa, Ontario, CanadaPopulation Studies Division, Health Canada, Ottawa, Ontario, CanadaOttawa Hospital Research Institute, Ottawa, Ontario, Canada; Better Outcomes Registry and Network Ontario, Ottawa, Ontario, Canada; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, CanadaAir Health Science Division, Health Canada, Ottawa, Ontario, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, CanadaBackground: Cardiovascular malformations account for nearly one-third of all congenital anomalies, making these the most common type of birth defects. Little is known regarding the influence of ambient ultrafine particles (<0.1 μm) (UFPs) on their occurrence. Objective: This population-based study examined the association between prenatal exposure to UFPs and congenital heart defects (CHDs). Methods: A total of 158,743 singleton live births occurring in the City of Toronto, Canada between April 1st 2006 and March 31st 2012 were identified from a birth registry. Associations between exposure to ambient UFPs between the 2nd and 8th week post conception when the foetal heart begins to form and CHDs identified at birth were estimated using random-effects logistic regression models, adjusting for personal- and neighbourhood-level covariates. We also investigated multi-pollutant models accounting for co-exposures to PM2.5, NO2 and O3. Results: A total of 1468 CHDs were identified. In fully adjusted models, UFP exposures during weeks 2 to 8 of pregnancy were not associated with overall CHDs (Odds Ratio (OR) per interquartile (IQR) increase = 1.02, 95% CI: 0.96–1.08). When investigating subtypes of CHDs, UFP exposures were associated with ventricular septal defects (Odds Ratio (OR) per interquartile (IQR) increase = 1.13, 95% CI: 1.03–1.33), but not with atrial septal defect (Odds Ratio (OR) per interquartile (IQR) increase = 0.89, 95% CI: 0.74–1.06). Conclusion: This is the first study to evaluate the association between prenatal exposure to UFPs and the risk of CHDs. UFP exposures during a critical period of embryogenesis were associated with an increased risk of ventricular septal defect. Keywords: Ultrafine particle, Air pollution, Prenatal, Congenital heart defecthttp://www.sciencedirect.com/science/article/pii/S0160412019311080 |
| spellingShingle | Eric Lavigne Isac Lima Marianne Hatzopoulou Keith Van Ryswyk Mary Lou Decou Wei Luo Aaron van Donkelaar Randall V. Martin Hong Chen David M. Stieb Eric Crighton Antonio Gasparrini Michael Elten Abdool S. Yasseen, III Richard T. Burnett Mark Walker Scott Weichenthal Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects Environment International |
| title | Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects |
| title_full | Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects |
| title_fullStr | Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects |
| title_full_unstemmed | Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects |
| title_short | Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects |
| title_sort | spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects |
| url | http://www.sciencedirect.com/science/article/pii/S0160412019311080 |
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