The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs
The short- and long-term stability of multi-component mixtures and intermediate mixtures of analytical standards of veterinary drugs, which can potentially occur in food and feed chains, was examined by an isochronous measurement approach. Short-term stability testing of calibrants included storage...
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| Format: | Article |
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Academy of National Food and Strategic Reserves Administration
2021-11-01
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| Series: | Liang you shipin ke-ji |
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| Online Access: | http://lyspkj.ijournal.cn/lyspkj/article/abstract/20210613?st=article_issue |
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| author | LIDIJA Kenjeric MICHAEL Sulyok ALEXANDRA Malachova DAVID Steiner RUDOLF Krska BRIAN Quinn BRETT Greer CHRISTOPHER T.Elliott |
| author_facet | LIDIJA Kenjeric MICHAEL Sulyok ALEXANDRA Malachova DAVID Steiner RUDOLF Krska BRIAN Quinn BRETT Greer CHRISTOPHER T.Elliott |
| author_sort | LIDIJA Kenjeric |
| collection | DOAJ |
| description | The short- and long-term stability of multi-component mixtures and intermediate mixtures of analytical standards of veterinary drugs, which can potentially occur in food and feed chains, was examined by an isochronous measurement approach. Short-term stability testing of calibrants included storage for 1, 2,4, and 7 days at -20 ℃ (as a baseline) 4 ℃, and 23 ℃ (with and without exposure to sunlight), respectively.Long-term stability testing conditions of intermediate mixes were -20 ℃, 4 ℃, 23 ℃ (with and without exposure to sunlight), and control temperature at -80 ℃ while the testing period was 2, 4, 8, and 12 weeks,respectively. Results indicated that calibration standards should ideally be stored at 4 ℃ for only 1～2 days,without the presence of acid. Neutral storage conditions were acceptable even at room temperature. Storage of intermediate mixtures containing ß-lactams and cephalosporins for longer than 1 month under 4 ℃ and room temperature resulted in a loss of almost 90%. When it comes to the intermediate mixtures with penicillin V and G, acceptable storage conditions were 2 weeks at -20 ℃, without the presence of acid. Other classes of veterinary drugs were less critical as considers long-term stability. Overall, storage conditions at -20 ℃were considered optimal for long-term storage of intermediate mixes of veterinary drug standards. |
| first_indexed | 2024-03-13T08:08:31Z |
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| id | doaj.art-91df89bc3e834fb8b5eb5987e90adab7 |
| institution | Directory Open Access Journal |
| issn | 1007-7561 |
| language | English |
| last_indexed | 2024-03-13T08:08:31Z |
| publishDate | 2021-11-01 |
| publisher | Academy of National Food and Strategic Reserves Administration |
| record_format | Article |
| series | Liang you shipin ke-ji |
| spelling | doaj.art-91df89bc3e834fb8b5eb5987e90adab72023-06-01T01:40:00ZengAcademy of National Food and Strategic Reserves AdministrationLiang you shipin ke-ji1007-75612021-11-012969310510.16210/j.cnki.1007-7561.2021.06.006The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary DrugsLIDIJA Kenjeric0MICHAEL Sulyok1ALEXANDRA Malachova2DAVID Steiner3RUDOLF Krska4BRIAN Quinn5BRETT Greer6CHRISTOPHER T.Elliott7FFoQSI GmbH, FFoQSI Austrian Competence Centre for Feed & Food Quality, Safety and Innovation,3430 Tulln, AustriaInstitute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology(IFA-Tulln), University of Natural Resources and Life Sciences, Vienna, 3430 Tulln, AustriaFFoQSI GmbH, FFoQSI Austrian Competence Centre for Feed & Food Quality, Safety and Innovation,3430 Tulln, AustriaRomer Labs Diagnostic GmbH, Analytical Service Department, Technopark 5 3430 TullnInstitute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology(IFA-Tulln), University of Natural Resources and Life Sciences, Vienna, 3430 Tulln, Austria; Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, University Road,Belfast, BT7 1NN, Northern Ireland, United KingdomInstitute for Global Food Security, School of Biological Sciences, Queens University Belfast, University Road,Belfast, BT7 1NN, Northern Ireland, United KingdomInstitute for Global Food Security, School of Biological Sciences, Queens University Belfast, University Road,Belfast, BT7 1NN, Northern Ireland, United KingdomInstitute for Global Food Security, School of Biological Sciences, Queens University Belfast, University Road,Belfast, BT7 1NN, Northern Ireland, United KingdomThe short- and long-term stability of multi-component mixtures and intermediate mixtures of analytical standards of veterinary drugs, which can potentially occur in food and feed chains, was examined by an isochronous measurement approach. Short-term stability testing of calibrants included storage for 1, 2,4, and 7 days at -20 ℃ (as a baseline) 4 ℃, and 23 ℃ (with and without exposure to sunlight), respectively.Long-term stability testing conditions of intermediate mixes were -20 ℃, 4 ℃, 23 ℃ (with and without exposure to sunlight), and control temperature at -80 ℃ while the testing period was 2, 4, 8, and 12 weeks,respectively. Results indicated that calibration standards should ideally be stored at 4 ℃ for only 1～2 days,without the presence of acid. Neutral storage conditions were acceptable even at room temperature. Storage of intermediate mixtures containing ß-lactams and cephalosporins for longer than 1 month under 4 ℃ and room temperature resulted in a loss of almost 90%. When it comes to the intermediate mixtures with penicillin V and G, acceptable storage conditions were 2 weeks at -20 ℃, without the presence of acid. Other classes of veterinary drugs were less critical as considers long-term stability. Overall, storage conditions at -20 ℃were considered optimal for long-term storage of intermediate mixes of veterinary drug standards.http://lyspkj.ijournal.cn/lyspkj/article/abstract/20210613?st=article_issueveterinary drugslong-term stabilityshort-term stabilityisochronous measurementlc-ms/ms |
| spellingShingle | LIDIJA Kenjeric MICHAEL Sulyok ALEXANDRA Malachova DAVID Steiner RUDOLF Krska BRIAN Quinn BRETT Greer CHRISTOPHER T.Elliott The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs Liang you shipin ke-ji veterinary drugs long-term stability short-term stability isochronous measurement lc-ms/ms |
| title | The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs |
| title_full | The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs |
| title_fullStr | The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs |
| title_full_unstemmed | The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs |
| title_short | The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs |
| title_sort | challenge of standard stability in lc ms based multi analyte approaches for veterinary drugs |
| topic | veterinary drugs long-term stability short-term stability isochronous measurement lc-ms/ms |
| url | http://lyspkj.ijournal.cn/lyspkj/article/abstract/20210613?st=article_issue |
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