Postexposure treatment with a Src-PTK inhibitor in combination with N-l-acetyl cysteine to reduce noise-induced hearing loss

Postexposure treatment with a Src-PTK inhibitor in combination with N-l-acetyl cysteine to reduce noise-induced hearing loss

Both the antioxidant, N-l-acetyl cysteine (NAC), and the Src inhibitor, KX1-004, have been used to protect the cochlea from hazardous noise. In order to extend our previous work on KX1-004 with noise exposure, the current studies were undertaken with two goals: (1) to test the effectiveness of NAC a...

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Bibliographic Details
Main Authors: Eric C Bielefeld, Rebecca Wantuck, Donald Henderson
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2011-01-01
Series:Noise and Health
Subjects:
Apoptosis
cochlea
glutathione
noise
reactive oxygen species
Src
Online Access:http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2011;volume=13;issue=53;spage=292;epage=298;aulast=Bielefeld

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