EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENT
Background. The achievements of modern medicine contribute to the timely diagnosis of endocrine ophthalmopathy (EOP). However, treatment continues to be a complex task, the results of which do not satisfy the physician and the patient. Purpose of the study – to evaluate the effectiveness and saf...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Belarusian |
| Published: |
Grodno State Medical University
2018-11-01
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| Series: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| Subjects: | |
| Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2325/2123 |
| _version_ | 1830273700712153088 |
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| author | Krinets Zh. Krasilnikova V. Dudich O. |
| author_facet | Krinets Zh. Krasilnikova V. Dudich O. |
| author_sort | Krinets Zh. |
| collection | DOAJ |
| description | Background. The achievements of modern medicine contribute to the timely diagnosis of endocrine ophthalmopathy
(EOP). However, treatment continues to be a complex task, the results of which do not satisfy the physician and the
patient. Purpose of the study – to evaluate the effectiveness and safety of pulse therapy with methylprednisolone in the
treatment of active forms of endocrine ophthalmopathy. Material and methods. The analysis of the efficacy of treatment
of 36 patients with moderate intensity of pulsed EEG by methylprednisolone therapy was carried out. The minimum
cumulative dose of the drug was 4.5 grams.
Results. Reduction of the activity of the image intensifier on the CAS scale and reduction of the intensity of
inflammatory changes in soft tissues of the orbit was observed 1 month after the start of the drug administration.
After the abolition of pulse therapy, the positive effect was preserved in 29 of 36 positively responding patients, which
was 80.6%. Deterioration of the course of ophthalmopathy at the end of the course of treatment was recorded in 7
patients (19.4%), of which tobacco smoking was noted in 5 (71.4%) patients, the hormone condition was not stable in
2 (28.65%) patients, who required correction by endocrinologist.
Conclusions. The therapy used enabled to reduce the inflammatory process in the orbit within a short period of time,
and the subsequent scheme of the drug administration improved the effect and created a long-term remission. To treat
patients with EOC in order to provide a therapeutic effect, it is necessary to use the safest doses of glucocorticoids. The
definition of the prescribed therapy should be based on the degree of severity and activity of the process. |
| first_indexed | 2024-12-18T23:50:27Z |
| format | Article |
| id | doaj.art-91e36a77b1404ba698c2a21a35edba29 |
| institution | Directory Open Access Journal |
| issn | 2221-8785 2413-0109 |
| language | Belarusian |
| last_indexed | 2024-12-18T23:50:27Z |
| publishDate | 2018-11-01 |
| publisher | Grodno State Medical University |
| record_format | Article |
| series | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| spelling | doaj.art-91e36a77b1404ba698c2a21a35edba292022-12-21T20:47:01ZbelGrodno State Medical UniversityŽurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta2221-87852413-01092018-11-0116557658010.25298/2221-8785-2018-16-5-576-580EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENTKrinets Zh.0Krasilnikova V.1Dudich O.2Educational Institution “Grodno State Medical University”State Educational Institution “Belarusian Medical Academy of Po stgraduate Education”State Educational Institution “Belarusian Medical Academy of Po stgraduate Education”Background. The achievements of modern medicine contribute to the timely diagnosis of endocrine ophthalmopathy (EOP). However, treatment continues to be a complex task, the results of which do not satisfy the physician and the patient. Purpose of the study – to evaluate the effectiveness and safety of pulse therapy with methylprednisolone in the treatment of active forms of endocrine ophthalmopathy. Material and methods. The analysis of the efficacy of treatment of 36 patients with moderate intensity of pulsed EEG by methylprednisolone therapy was carried out. The minimum cumulative dose of the drug was 4.5 grams. Results. Reduction of the activity of the image intensifier on the CAS scale and reduction of the intensity of inflammatory changes in soft tissues of the orbit was observed 1 month after the start of the drug administration. After the abolition of pulse therapy, the positive effect was preserved in 29 of 36 positively responding patients, which was 80.6%. Deterioration of the course of ophthalmopathy at the end of the course of treatment was recorded in 7 patients (19.4%), of which tobacco smoking was noted in 5 (71.4%) patients, the hormone condition was not stable in 2 (28.65%) patients, who required correction by endocrinologist. Conclusions. The therapy used enabled to reduce the inflammatory process in the orbit within a short period of time, and the subsequent scheme of the drug administration improved the effect and created a long-term remission. To treat patients with EOC in order to provide a therapeutic effect, it is necessary to use the safest doses of glucocorticoids. The definition of the prescribed therapy should be based on the degree of severity and activity of the process.http://journal-grsmu.by/index.php/ojs/article/view/2325/2123endocrine ophthalmopathymethylprednisolonetreatment. |
| spellingShingle | Krinets Zh. Krasilnikova V. Dudich O. EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENT Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta endocrine ophthalmopathy methylprednisolone treatment. |
| title | EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENT |
| title_full | EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENT |
| title_fullStr | EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENT |
| title_full_unstemmed | EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENT |
| title_short | EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENT |
| title_sort | evaluation of efficiency of endocrine ophthalmopathy treatment |
| topic | endocrine ophthalmopathy methylprednisolone treatment. |
| url | http://journal-grsmu.by/index.php/ojs/article/view/2325/2123 |
| work_keys_str_mv | AT krinetszh evaluationofefficiencyofendocrineophthalmopathytreatment AT krasilnikovav evaluationofefficiencyofendocrineophthalmopathytreatment AT dudicho evaluationofefficiencyofendocrineophthalmopathytreatment |