Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review)
<p>Umbilical cord blood (CB) is now an attractive source of hematopoietic stem cells (HSCs) for transplantation in pediatric and adult patients with various malignant and non-malignant diseases. However, its clinical application is limited by low cells numbers in graft, which correlates with d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2014-07-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | http://oncohematology.abvpress.ru/index.php/ongm/article/view/68 |
| _version_ | 1797757545448734720 |
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| author | T. V. Shamanskaya E. Yu. Osipova S. A. Roumiantsev |
| author_facet | T. V. Shamanskaya E. Yu. Osipova S. A. Roumiantsev |
| author_sort | T. V. Shamanskaya |
| collection | DOAJ |
| description | <p>Umbilical cord blood (CB) is now an attractive source of hematopoietic stem cells (HSCs) for transplantation in pediatric and adult patients with various malignant and non-malignant diseases. However, its clinical application is limited by low cells numbers in graft, which correlates with delayed engraftment, an extension of time to platelets and neutrophils recovery and increasing risk of infectious complications. Several strategies have been suggested to overcome this limitation, one of which is obtaining a sufficient number of hematopoietic progenitor cells by ex vivo expansion. Literature review about CB HSCs expansion in given article is presented.</p> |
| first_indexed | 2024-03-12T18:17:18Z |
| format | Article |
| id | doaj.art-91e3877161db4799972383f8140b3e12 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 |
| language | Russian |
| last_indexed | 2024-03-12T18:17:18Z |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-91e3877161db4799972383f8140b3e122023-08-02T09:04:42ZrusABV-pressОнкогематология1818-83462014-07-0171354583Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review)T. V. Shamanskaya0E. Yu. Osipova1S. A. Roumiantsev2Dmitiry Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyDmitiry Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyDmitiry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology<p>Umbilical cord blood (CB) is now an attractive source of hematopoietic stem cells (HSCs) for transplantation in pediatric and adult patients with various malignant and non-malignant diseases. However, its clinical application is limited by low cells numbers in graft, which correlates with delayed engraftment, an extension of time to platelets and neutrophils recovery and increasing risk of infectious complications. Several strategies have been suggested to overcome this limitation, one of which is obtaining a sufficient number of hematopoietic progenitor cells by ex vivo expansion. Literature review about CB HSCs expansion in given article is presented.</p>http://oncohematology.abvpress.ru/index.php/ongm/article/view/68cord bloodex vivo expansioncytokines |
| spellingShingle | T. V. Shamanskaya E. Yu. Osipova S. A. Roumiantsev Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review) Онкогематология cord blood ex vivo expansion cytokines |
| title | Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review) |
| title_full | Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review) |
| title_fullStr | Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review) |
| title_full_unstemmed | Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review) |
| title_short | Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review) |
| title_sort | umbilical cord bloods hematopoietic stem cells ex vivo expansion the literature review |
| topic | cord blood ex vivo expansion cytokines |
| url | http://oncohematology.abvpress.ru/index.php/ongm/article/view/68 |
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