Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction

Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction

TAR DNA-binding protein 43 (TDP-43) is a member of an evolutionarily conserved family of heterogeneous nuclear ribonucleoproteins that modulate multiple steps in RNA metabolic processes. Cytoplasmic aggregation of TDP-43 in affected neurons is a pathological hallmark of many neurodegenerative diseas...

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Bibliographic Details
Main Authors: Yu-Mi Jeon, Younghwi Kwon, Shinrye Lee, Seyeon Kim, Myungjin Jo, Seongsoo Lee, Sang Ryong Kim, Kiyoung Kim, Hyung-Jun Kim
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
TAR DNA-binding protein 43
amyotrophic lateral sclerosis
<i>Drosophila</i>
mitochondrial dysfunction
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/11/1/82

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