Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction

Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction

TAR DNA-binding protein 43 (TDP-43) is a member of an evolutionarily conserved family of heterogeneous nuclear ribonucleoproteins that modulate multiple steps in RNA metabolic processes. Cytoplasmic aggregation of TDP-43 in affected neurons is a pathological hallmark of many neurodegenerative diseas...

書目詳細資料
Main Authors:	Yu-Mi Jeon, Younghwi Kwon, Shinrye Lee, Seyeon Kim, Myungjin Jo, Seongsoo Lee, Sang Ryong Kim, Kiyoung Kim, Hyung-Jun Kim
格式:	Article
語言:	English
出版:	MDPI AG 2021-12-01
叢編:	Antioxidants
主題:	TAR DNA-binding protein 43 amyotrophic lateral sclerosis <i>Drosophila</i> mitochondrial dysfunction oxidative stress
在線閱讀:	https://www.mdpi.com/2076-3921/11/1/82

相似書籍

The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment
由: Shinrye Lee, et al.
出版: (2020-11-01)

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
由: Shinrye Lee, et al.
出版: (2020-10-01)

Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3
由: Jeong Hyang Park, et al.
出版: (2020-12-01)

HEXA-018, a Novel Inducer of Autophagy, Rescues TDP-43 Toxicity in Neuronal Cells
由: Shinrye Lee, et al.
出版: (2021-12-01)

Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation
由: N. Kreiter, et al.
出版: (2018-07-01)

Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation
由: Jae-Hong Kim, et al.
出版: (2021-03-01)

TDP-43 regulates endogenous retrovirus-K viral protein accumulation
由: Mamneet Manghera, et al.
出版: (2016-10-01)

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
由: Laetitia Miguel, et al.
出版: (2011-02-01)

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation
由: Saebom Lee, et al.
出版: (2022-12-01)

Respiratory pathology in the TDP-43 transgenic mouse model of amyotrophic lateral sclerosis
由: Debolina D. Biswas, et al.
出版: (2024-08-01)

The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
由: Myungjin Jo, et al.
出版: (2020-10-01)

CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
由: Vivian I. Ko, et al.
出版: (2024-06-01)

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
由: Yuting Ren, et al.
出版: (2021-06-01)

Methodology Aspects of Colony Maintain for a Murine Model of Amyotrophic Lateral Sclerosis (ALS) TDP-43 Proteinopathy
由: César Álvaro-Alonso, et al.
出版: (2020-12-01)

TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish
由: Maria-Letizia Campanari, et al.
出版: (2021-01-01)

TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis
由: Svetlana Djukic, et al.
出版: (2025-02-01)

Low T-cell reactivity to TDP-43 peptides in ALS
由: Swetha Ramachandran, et al.
出版: (2023-07-01)

Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines
由: Alexandra Lissouba, et al.
出版: (2018-12-01)

Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration
由: Benjamin G. Trist, et al.
出版: (2022-08-01)

Glutathione S-Transferase Rescues Motor Neuronal Toxicity in Fly Model of Amyotrophic Lateral Sclerosis
由: Sun Joo Cha, et al.
出版: (2020-07-01)

Aberrant TDP‐43 phosphorylation: a key wind gap from TDP‐43 to TDP‐43 proteinopathy
由: Zi‐Qi Huang, et al.
出版: (2021-06-01)

Cyclin F can alter the turnover of TDP-43
由: Stephanie L. Rayner, et al.
出版: (2024-03-01)

TDP-43 Proteinopathy Specific Biomarker Development
由: Isabell Cordts, et al.
出版: (2023-02-01)

TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients
由: Miguel A. Rubio, et al.
出版: (2022-01-01)

The role of TDP-43 protein in amyotrophic lateral sclerosis
由: Piotr Włodarczyk, et al.
出版: (2022-12-01)

Advancements in TDP-43 research: Towards biomarkers and therapeutic targets for amyotrophic lateral sclerosis
由: Yuhan Wu, et al.
出版: (2025-03-01)

Cytoplasmic Human TDP-43 Mislocalization Induces Widespread Dendritic Spine Loss in Mouse Upper Motor Neurons
由: Marcus S. Dyer, et al.
出版: (2021-06-01)

Validation of a newly developed immunoassay for TDP-43 in human plasma
由: Sayo Matsuura, et al.
出版: (2024-01-01)

Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
由: Eric N Anderson, et al.
出版: (2021-06-01)

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration
由: Seiji Watanabe, et al.
出版: (2020-01-01)

Increased metal content in the TDP-43A315T transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
由: Theresa eDang, et al.
出版: (2014-02-01)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
由: Rachel Atkinson, et al.
出版: (2021-02-01)

Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation
由: Donya Pakravan, et al.
出版: (2021-04-01)

Distinct Phospho-TDP-43 brain distribution in two cases of FTD, one associated with ALS
由: Álvaro C.B. Guedes, et al.

Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis
由: Rachel H. Tan, et al.
出版: (2023-11-01)

TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex
由: Stephanie L. Rayner, et al.
出版: (2022-06-01)

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo
由: Hibiki Kawamata, et al.
出版: (2017-05-01)

A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue
由: Maize C. Cao, et al.
出版: (2023-09-01)

The effect of pH alterations on TDP-43 in a cellular model of amyotrophic lateral sclerosis
由: Yara Al Ojaimi, et al.
出版: (2024-07-01)

A robust TDP-43 knock-in mouse model of ALS
由: Shih-Ling Huang, et al.
出版: (2020-01-01)