Strategies for the Prevention of Invasive Fungal Infections after Lung Transplant
Long-term survival after lung transplantation is lower than that associated with other transplanted organs. Infectious complications, most importantly invasive fungal infections, have detrimental effects and are a major cause of morbidity and mortality in this population. <i>Candida</i>...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/7/2/122 |
| _version_ | 1827602221320110080 |
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| author | Roni Bitterman Tina Marinelli Shahid Husain |
| author_facet | Roni Bitterman Tina Marinelli Shahid Husain |
| author_sort | Roni Bitterman |
| collection | DOAJ |
| description | Long-term survival after lung transplantation is lower than that associated with other transplanted organs. Infectious complications, most importantly invasive fungal infections, have detrimental effects and are a major cause of morbidity and mortality in this population. <i>Candida</i> infections predominate in the early post-transplant period, whereas invasive mold infections, usually those related to <i>Aspergillus</i>, are most common later on. This review summarizes the epidemiology and risk factors for invasive fungal diseases in lung transplant recipients, as well as the current evidence on preventive measures. These measures include universal prophylaxis, targeted prophylaxis, and preemptive treatment. Although there is consensus that a preventive strategy should be implemented, current data show no superiority of one preventive measure over another. Data are also lacking regarding the optimal antifungal regimen and the duration of treatment. As all current recommendations are based on observational, single-center, single-arm studies, it is necessary that this longstanding debate is settled with a multicenter randomized controlled trial. |
| first_indexed | 2024-03-09T05:13:11Z |
| format | Article |
| id | doaj.art-91e676b2109b478e8b06b5128316fcb1 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T05:13:11Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-91e676b2109b478e8b06b5128316fcb12023-12-03T12:47:21ZengMDPI AGJournal of Fungi2309-608X2021-02-017212210.3390/jof7020122Strategies for the Prevention of Invasive Fungal Infections after Lung TransplantRoni Bitterman0Tina Marinelli1Shahid Husain2Transplant Infectious Diseases, Ajmera Transplant Center, University Health Network, University of Toronto, Toronto, ON M5G 2C4, CanadaTransplant Infectious Diseases, Ajmera Transplant Center, University Health Network, University of Toronto, Toronto, ON M5G 2C4, CanadaTransplant Infectious Diseases, Ajmera Transplant Center, University Health Network, University of Toronto, Toronto, ON M5G 2C4, CanadaLong-term survival after lung transplantation is lower than that associated with other transplanted organs. Infectious complications, most importantly invasive fungal infections, have detrimental effects and are a major cause of morbidity and mortality in this population. <i>Candida</i> infections predominate in the early post-transplant period, whereas invasive mold infections, usually those related to <i>Aspergillus</i>, are most common later on. This review summarizes the epidemiology and risk factors for invasive fungal diseases in lung transplant recipients, as well as the current evidence on preventive measures. These measures include universal prophylaxis, targeted prophylaxis, and preemptive treatment. Although there is consensus that a preventive strategy should be implemented, current data show no superiority of one preventive measure over another. Data are also lacking regarding the optimal antifungal regimen and the duration of treatment. As all current recommendations are based on observational, single-center, single-arm studies, it is necessary that this longstanding debate is settled with a multicenter randomized controlled trial.https://www.mdpi.com/2309-608X/7/2/122lung transplantationinvasive fungal diseaseinvasive aspergillosisprophylaxispreemptive treatment |
| spellingShingle | Roni Bitterman Tina Marinelli Shahid Husain Strategies for the Prevention of Invasive Fungal Infections after Lung Transplant Journal of Fungi lung transplantation invasive fungal disease invasive aspergillosis prophylaxis preemptive treatment |
| title | Strategies for the Prevention of Invasive Fungal Infections after Lung Transplant |
| title_full | Strategies for the Prevention of Invasive Fungal Infections after Lung Transplant |
| title_fullStr | Strategies for the Prevention of Invasive Fungal Infections after Lung Transplant |
| title_full_unstemmed | Strategies for the Prevention of Invasive Fungal Infections after Lung Transplant |
| title_short | Strategies for the Prevention of Invasive Fungal Infections after Lung Transplant |
| title_sort | strategies for the prevention of invasive fungal infections after lung transplant |
| topic | lung transplantation invasive fungal disease invasive aspergillosis prophylaxis preemptive treatment |
| url | https://www.mdpi.com/2309-608X/7/2/122 |
| work_keys_str_mv | AT ronibitterman strategiesforthepreventionofinvasivefungalinfectionsafterlungtransplant AT tinamarinelli strategiesforthepreventionofinvasivefungalinfectionsafterlungtransplant AT shahidhusain strategiesforthepreventionofinvasivefungalinfectionsafterlungtransplant |