Motor neuron activity enhances the proteomic stress caused by autophagy defects in the target muscle.

Motor neuron activity enhances the proteomic stress caused by autophagy defects in the target muscle.

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Several lines of evidence demonstrate that increased neuronal excitability can enhance proteomic stress. For example, epilepsy can enhance the proteomic stress caused by the expression of certain aggregation-prone proteins implicated in neurodegeneration. However, unanswered questions remain concern...

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Bibliographic Details
Main Authors: Saurabh Srivastav, Kevin van der Graaf, Prisha C Jonnalagadda, Maanvi Thawani, James A McNew, Michael Stern
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0291477&type=printable

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