Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional study
Abstract This study examines the effects of environmental hazards, including tobacco, alcohol/alcohol flush response, areca nut, and Helicobacter pylori (H pylori) infection on upper digestive diseases. This is a multi‐hospital‐based endoscopy‐survey cross‐sectional study. Subjects were received upp...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/kjm2.12071 |
| _version_ | 1828165272695996416 |
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| author | Yun‐Shiuan Chuang Meng‐Chieh Wu Yao‐Kuang Wang Yi‐Hsun Chen Chao‐Hung Kuo Deng‐Chyang Wu Ming‐Tsang Wu I‐Chen Wu |
| author_facet | Yun‐Shiuan Chuang Meng‐Chieh Wu Yao‐Kuang Wang Yi‐Hsun Chen Chao‐Hung Kuo Deng‐Chyang Wu Ming‐Tsang Wu I‐Chen Wu |
| author_sort | Yun‐Shiuan Chuang |
| collection | DOAJ |
| description | Abstract This study examines the effects of environmental hazards, including tobacco, alcohol/alcohol flush response, areca nut, and Helicobacter pylori (H pylori) infection on upper digestive diseases. This is a multi‐hospital‐based endoscopy‐survey cross‐sectional study. Subjects were received upper endoscopies in outpatient clinics at four hospitals in Taiwan between 2008 and 2013. Biopsy‐based methods or urea breath test were used confirm the status of H pylori infection. In total, 8135 subjects were analyzed. Higher cumulative amounts of alcohol consumption were at higher risk of Barrett's esophagus and esophageal squamous cell carcinoma (ESCC), higher cumulative amounts of tobacco consumption were at higher risk of peptic ulcer, and higher cumulative amounts of areca nut consumption were at higher risk of duodenitis. Alcohol flush response was significant risk for reflux esophagitis and Barrett's esophagus (adjusted odds ratio [aOR] = 1.18 and 1.32, 95% confidence interval [CI] = 1.07‐1.31 and 1.06‐1.65, respectively). H pylori infection was inversely associated with ESCC risk (aOR = 0.20, 95% CI = 0.10‐0.40). In addition, H pylori infection was consistently and significantly risk factors for gastrointestinal diseases, including peptic ulcer, gastric adenocarcinoma, and duodenitis (aOR = 5.51, 1.84, and 2.10, 95% CI = 4.85‐6.26, 1.03‐3.26, and 1.71‐2.56, respectively). Besides the cumulative risk of alcohol, tobacco, and areca nut for Barrett's esophagus, ESCC, and peptic ulcer, respectively, presence of facial flushing was the significant risk for reflux esophagitis and Barrett's esophagus. H pylori infection was positively associated with peptic ulcer, gastric adenocarcinoma, and duodenitis, but inversely associated with ESCC. |
| first_indexed | 2024-04-12T01:40:53Z |
| format | Article |
| id | doaj.art-91e783b238e64521a2f3ce2a3e94a38e |
| institution | Directory Open Access Journal |
| issn | 1607-551X 2410-8650 |
| language | English |
| last_indexed | 2024-04-12T01:40:53Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-91e783b238e64521a2f3ce2a3e94a38e2022-12-22T03:53:12ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502019-06-0135634134910.1002/kjm2.12071Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional studyYun‐Shiuan Chuang0Meng‐Chieh Wu1Yao‐Kuang Wang2Yi‐Hsun Chen3Chao‐Hung Kuo4Deng‐Chyang Wu5Ming‐Tsang Wu6I‐Chen Wu7Department of Public Health, College of Health Sciences Kaohsiung Medical University Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Public Health, College of Health Sciences Kaohsiung Medical University Kaohsiung TaiwanDivision of Gastroenterology, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanAbstract This study examines the effects of environmental hazards, including tobacco, alcohol/alcohol flush response, areca nut, and Helicobacter pylori (H pylori) infection on upper digestive diseases. This is a multi‐hospital‐based endoscopy‐survey cross‐sectional study. Subjects were received upper endoscopies in outpatient clinics at four hospitals in Taiwan between 2008 and 2013. Biopsy‐based methods or urea breath test were used confirm the status of H pylori infection. In total, 8135 subjects were analyzed. Higher cumulative amounts of alcohol consumption were at higher risk of Barrett's esophagus and esophageal squamous cell carcinoma (ESCC), higher cumulative amounts of tobacco consumption were at higher risk of peptic ulcer, and higher cumulative amounts of areca nut consumption were at higher risk of duodenitis. Alcohol flush response was significant risk for reflux esophagitis and Barrett's esophagus (adjusted odds ratio [aOR] = 1.18 and 1.32, 95% confidence interval [CI] = 1.07‐1.31 and 1.06‐1.65, respectively). H pylori infection was inversely associated with ESCC risk (aOR = 0.20, 95% CI = 0.10‐0.40). In addition, H pylori infection was consistently and significantly risk factors for gastrointestinal diseases, including peptic ulcer, gastric adenocarcinoma, and duodenitis (aOR = 5.51, 1.84, and 2.10, 95% CI = 4.85‐6.26, 1.03‐3.26, and 1.71‐2.56, respectively). Besides the cumulative risk of alcohol, tobacco, and areca nut for Barrett's esophagus, ESCC, and peptic ulcer, respectively, presence of facial flushing was the significant risk for reflux esophagitis and Barrett's esophagus. H pylori infection was positively associated with peptic ulcer, gastric adenocarcinoma, and duodenitis, but inversely associated with ESCC.https://doi.org/10.1002/kjm2.12071alcohol flush responseareca nutBarrett's esophagusesophageal squamous cell carcinomaHelicobacter pylori |
| spellingShingle | Yun‐Shiuan Chuang Meng‐Chieh Wu Yao‐Kuang Wang Yi‐Hsun Chen Chao‐Hung Kuo Deng‐Chyang Wu Ming‐Tsang Wu I‐Chen Wu Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional study Kaohsiung Journal of Medical Sciences alcohol flush response areca nut Barrett's esophagus esophageal squamous cell carcinoma Helicobacter pylori |
| title | Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional study |
| title_full | Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional study |
| title_fullStr | Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional study |
| title_full_unstemmed | Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional study |
| title_short | Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional study |
| title_sort | risks of substance uses alcohol flush response helicobacter pylori infection and upper digestive tract diseases an endoscopy cross sectional study |
| topic | alcohol flush response areca nut Barrett's esophagus esophageal squamous cell carcinoma Helicobacter pylori |
| url | https://doi.org/10.1002/kjm2.12071 |
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