Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges
Nervous system diseases present significant challenges to the neuroscience community due to ethical and practical constraints that limit access to appropriate research materials. Somatic cell reprogramming has been proposed as a novel way to obtain neurons. Various emerging techniques have been used...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/3/524 |
| _version_ | 1797613070557642752 |
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| author | Jiafeng Chen Lijuan Huang Yue Yang Wei Xu Qingchun Qin Rongxing Qin Xiaojun Liang Xinyu Lai Xiaoying Huang Minshan Xie Li Chen |
| author_facet | Jiafeng Chen Lijuan Huang Yue Yang Wei Xu Qingchun Qin Rongxing Qin Xiaojun Liang Xinyu Lai Xiaoying Huang Minshan Xie Li Chen |
| author_sort | Jiafeng Chen |
| collection | DOAJ |
| description | Nervous system diseases present significant challenges to the neuroscience community due to ethical and practical constraints that limit access to appropriate research materials. Somatic cell reprogramming has been proposed as a novel way to obtain neurons. Various emerging techniques have been used to reprogram mature and differentiated cells into neurons. This review provides an overview of somatic cell reprogramming for neurological research and therapy, focusing on neural reprogramming and generating different neural cell types. We examine the mechanisms involved in reprogramming and the challenges that arise. We herein summarize cell reprogramming strategies to generate neurons, including transcription factors, small molecules, and microRNAs, with a focus on different types of cells.. While reprogramming somatic cells into neurons holds the potential for understanding neurological diseases and developing therapeutic applications, its limitations and risks must be carefully considered. Here, we highlight the potential benefits of somatic cell reprogramming for neurological disease research and therapy. This review contributes to the field by providing a comprehensive overview of the various techniques used to generate neurons by cellular reprogramming and discussing their potential applications. |
| first_indexed | 2024-03-11T06:50:45Z |
| format | Article |
| id | doaj.art-91e803fa21324269ad0262457d8c100b |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T06:50:45Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-91e803fa21324269ad0262457d8c100b2023-11-17T10:01:06ZengMDPI AGBrain Sciences2076-34252023-03-0113352410.3390/brainsci13030524Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and ChallengesJiafeng Chen0Lijuan Huang1Yue Yang2Wei Xu3Qingchun Qin4Rongxing Qin5Xiaojun Liang6Xinyu Lai7Xiaoying Huang8Minshan Xie9Li Chen10Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaKey Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaNervous system diseases present significant challenges to the neuroscience community due to ethical and practical constraints that limit access to appropriate research materials. Somatic cell reprogramming has been proposed as a novel way to obtain neurons. Various emerging techniques have been used to reprogram mature and differentiated cells into neurons. This review provides an overview of somatic cell reprogramming for neurological research and therapy, focusing on neural reprogramming and generating different neural cell types. We examine the mechanisms involved in reprogramming and the challenges that arise. We herein summarize cell reprogramming strategies to generate neurons, including transcription factors, small molecules, and microRNAs, with a focus on different types of cells.. While reprogramming somatic cells into neurons holds the potential for understanding neurological diseases and developing therapeutic applications, its limitations and risks must be carefully considered. Here, we highlight the potential benefits of somatic cell reprogramming for neurological disease research and therapy. This review contributes to the field by providing a comprehensive overview of the various techniques used to generate neurons by cellular reprogramming and discussing their potential applications.https://www.mdpi.com/2076-3425/13/3/524nervous system diseasesneurosciencesomatic cellreprogrammingneuronsmechanisms |
| spellingShingle | Jiafeng Chen Lijuan Huang Yue Yang Wei Xu Qingchun Qin Rongxing Qin Xiaojun Liang Xinyu Lai Xiaoying Huang Minshan Xie Li Chen Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges Brain Sciences nervous system diseases neuroscience somatic cell reprogramming neurons mechanisms |
| title | Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges |
| title_full | Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges |
| title_fullStr | Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges |
| title_full_unstemmed | Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges |
| title_short | Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges |
| title_sort | somatic cell reprogramming for nervous system diseases techniques mechanisms potential applications and challenges |
| topic | nervous system diseases neuroscience somatic cell reprogramming neurons mechanisms |
| url | https://www.mdpi.com/2076-3425/13/3/524 |
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