The Influence of the microbiome on the innate immune microenvironment of solid tumors
Cancer remains a leading cause of death despite many advances in medical and surgical therapy. In recent decades, the investigation for novel therapeutic strategies with greater efficacy and reduced side effects has led to a deeper understanding of the relationship between the microbiome and the imm...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558623000039 |
| _version_ | 1797897311989268480 |
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| author | Angel Charles Ryan M. Thomas |
| author_facet | Angel Charles Ryan M. Thomas |
| author_sort | Angel Charles |
| collection | DOAJ |
| description | Cancer remains a leading cause of death despite many advances in medical and surgical therapy. In recent decades, the investigation for novel therapeutic strategies with greater efficacy and reduced side effects has led to a deeper understanding of the relationship between the microbiome and the immune system in the context of cancer. The ability of the immune system to detect and kill cancer is now recognized to be greatly influenced by the microbial ecosystem of the host. While most of these studies, as well as currently used immunotherapeutics, focus on the adaptive immune system, this minimizes the impact of the innate immune system in cancer surveillance and its regulation by the host microbiome. In this review, known influences of the microbiome on the innate immune cells in the tumor microenvironment will be discussed in the context of individual innate immune cells. Current and needed areas of investigation will highlight the field and its potential impact in the clinical treatment of solid malignancies. |
| first_indexed | 2024-04-10T07:56:34Z |
| format | Article |
| id | doaj.art-91e91f60ef3d473390216af94f0767a0 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-04-10T07:56:34Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-91e91f60ef3d473390216af94f0767a02023-02-23T04:30:36ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862023-03-0137100878The Influence of the microbiome on the innate immune microenvironment of solid tumorsAngel Charles0Ryan M. Thomas1Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USADepartment of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA; Corresponding author at: University of Florida, Department of Surgery, PO Box 100109, Gainesville, FL 32610, USACancer remains a leading cause of death despite many advances in medical and surgical therapy. In recent decades, the investigation for novel therapeutic strategies with greater efficacy and reduced side effects has led to a deeper understanding of the relationship between the microbiome and the immune system in the context of cancer. The ability of the immune system to detect and kill cancer is now recognized to be greatly influenced by the microbial ecosystem of the host. While most of these studies, as well as currently used immunotherapeutics, focus on the adaptive immune system, this minimizes the impact of the innate immune system in cancer surveillance and its regulation by the host microbiome. In this review, known influences of the microbiome on the innate immune cells in the tumor microenvironment will be discussed in the context of individual innate immune cells. Current and needed areas of investigation will highlight the field and its potential impact in the clinical treatment of solid malignancies.http://www.sciencedirect.com/science/article/pii/S1476558623000039Innate immunityMicrobiomeOncobiomeCancerTumor microenvironment |
| spellingShingle | Angel Charles Ryan M. Thomas The Influence of the microbiome on the innate immune microenvironment of solid tumors Neoplasia: An International Journal for Oncology Research Innate immunity Microbiome Oncobiome Cancer Tumor microenvironment |
| title | The Influence of the microbiome on the innate immune microenvironment of solid tumors |
| title_full | The Influence of the microbiome on the innate immune microenvironment of solid tumors |
| title_fullStr | The Influence of the microbiome on the innate immune microenvironment of solid tumors |
| title_full_unstemmed | The Influence of the microbiome on the innate immune microenvironment of solid tumors |
| title_short | The Influence of the microbiome on the innate immune microenvironment of solid tumors |
| title_sort | influence of the microbiome on the innate immune microenvironment of solid tumors |
| topic | Innate immunity Microbiome Oncobiome Cancer Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S1476558623000039 |
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