Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility
The ABC method is a classification method used for stratifying the risk of gastric cancer. However, whether the ABC method should be performed only once or multiple times throughout an individual’s lifetime remains unclear. Therefore, this study aimed to analyze whether performing ABC screening twic...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/7/1284 |
| _version_ | 1827747003511078912 |
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| author | Satoru Mizutani Yu Takahashi Takeshi Shimamoto Hideki Nakagawa Hiroyuki Hisada Kaori Oshio Dai Kubota Hiroya Mizutani Daisuke Ohki Yoshiki Sakaguchi Seiichi Yakabi Keiko Niimi Naomi Kakushima Yosuke Tsuji Ryoichi Wada Nobutake Yamamichi Mitsuhiro Fujishiro |
| author_facet | Satoru Mizutani Yu Takahashi Takeshi Shimamoto Hideki Nakagawa Hiroyuki Hisada Kaori Oshio Dai Kubota Hiroya Mizutani Daisuke Ohki Yoshiki Sakaguchi Seiichi Yakabi Keiko Niimi Naomi Kakushima Yosuke Tsuji Ryoichi Wada Nobutake Yamamichi Mitsuhiro Fujishiro |
| author_sort | Satoru Mizutani |
| collection | DOAJ |
| description | The ABC method is a classification method used for stratifying the risk of gastric cancer. However, whether the ABC method should be performed only once or multiple times throughout an individual’s lifetime remains unclear. Therefore, this study aimed to analyze whether performing ABC screening twice in a lifetime is useful. We retrospectively analyzed the data of individuals who participated in health checkups in 2010 and 2015. We collected data on patient characteristics, pepsinogen levels, anti-<i>Helicobacter pylori</i> antibody titers, and the presence of gastric cancer. Overall, 7129 participants without a history of <i>H. pylori</i> eradication were included in this study. The participants’ average age in 2010 was 48.4 ± 8.3 years, and 58.1% were male. In addition, 11 and 20 cases of new <i>H. pylori</i> infection (0.15%) and spontaneous eradication (0.28%), respectively, were recorded. No significant difference was found in the incidence of gastric cancer between participants who underwent the ABC method once and those who underwent it twice (Group A: 0.16% vs. 0.16%; Group B: 0.47% vs. 0.39%; and Group C + D: 1.97% vs. 1.82%). Therefore, performing the ABC method twice, 5 years apart, does not significantly improve gastric cancer risk stratification. |
| first_indexed | 2024-03-11T05:40:00Z |
| format | Article |
| id | doaj.art-91e9323c060e492cbe00158aa96b4d66 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T05:40:00Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-91e9323c060e492cbe00158aa96b4d662023-11-17T16:30:26ZengMDPI AGDiagnostics2075-44182023-03-01137128410.3390/diagnostics13071284Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening FacilitySatoru Mizutani0Yu Takahashi1Takeshi Shimamoto2Hideki Nakagawa3Hiroyuki Hisada4Kaori Oshio5Dai Kubota6Hiroya Mizutani7Daisuke Ohki8Yoshiki Sakaguchi9Seiichi Yakabi10Keiko Niimi11Naomi Kakushima12Yosuke Tsuji13Ryoichi Wada14Nobutake Yamamichi15Mitsuhiro Fujishiro16Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanKameda Medical Center Makuhari CD 2F, 1-3 Nakase, Mihama-ku, Chiba-City, Chiba 261-8501, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanKameda Medical Center Makuhari CD 2F, 1-3 Nakase, Mihama-ku, Chiba-City, Chiba 261-8501, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanThe ABC method is a classification method used for stratifying the risk of gastric cancer. However, whether the ABC method should be performed only once or multiple times throughout an individual’s lifetime remains unclear. Therefore, this study aimed to analyze whether performing ABC screening twice in a lifetime is useful. We retrospectively analyzed the data of individuals who participated in health checkups in 2010 and 2015. We collected data on patient characteristics, pepsinogen levels, anti-<i>Helicobacter pylori</i> antibody titers, and the presence of gastric cancer. Overall, 7129 participants without a history of <i>H. pylori</i> eradication were included in this study. The participants’ average age in 2010 was 48.4 ± 8.3 years, and 58.1% were male. In addition, 11 and 20 cases of new <i>H. pylori</i> infection (0.15%) and spontaneous eradication (0.28%), respectively, were recorded. No significant difference was found in the incidence of gastric cancer between participants who underwent the ABC method once and those who underwent it twice (Group A: 0.16% vs. 0.16%; Group B: 0.47% vs. 0.39%; and Group C + D: 1.97% vs. 1.82%). Therefore, performing the ABC method twice, 5 years apart, does not significantly improve gastric cancer risk stratification.https://www.mdpi.com/2075-4418/13/7/1284ABC methodgastric cancer<i>H. pylori</i>pepsinogenrisk stratification |
| spellingShingle | Satoru Mizutani Yu Takahashi Takeshi Shimamoto Hideki Nakagawa Hiroyuki Hisada Kaori Oshio Dai Kubota Hiroya Mizutani Daisuke Ohki Yoshiki Sakaguchi Seiichi Yakabi Keiko Niimi Naomi Kakushima Yosuke Tsuji Ryoichi Wada Nobutake Yamamichi Mitsuhiro Fujishiro Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility Diagnostics ABC method gastric cancer <i>H. pylori</i> pepsinogen risk stratification |
| title | Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility |
| title_full | Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility |
| title_fullStr | Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility |
| title_full_unstemmed | Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility |
| title_short | Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility |
| title_sort | performing the abc method twice for gastric cancer risk stratification a retrospective study based on data from a large scale screening facility |
| topic | ABC method gastric cancer <i>H. pylori</i> pepsinogen risk stratification |
| url | https://www.mdpi.com/2075-4418/13/7/1284 |
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