Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM

Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM

Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options. The purposes of this study were to evaluate the in vitro antibacterial activity of novel β-lactam-β-lactamase inhibitor combinatio...

Full description

Bibliographic Details
Main Authors:	Xinhui Li, Jisheng Zhang, Jianmin Wang, Wenzhang Long, Xushan Liang, Yang Yang, Xue Gong, Jie Li, Longjin Liu, Xiaoli Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Microbiology
Subjects:	carbapenem-resistant Klebsiella pneumoniae β-lactamase inhibitor bactericidal effect time-kill assay aztreonam
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1210313/full

Similar Items

In vitro Synergistic Activity of Ceftazidime-Avibactam in Combination with Aztreonam or Meropenem Against Clinical Enterobacterales Producing blaKPC or blaNDM
by: Kuai J, et al.
Published: (2023-05-01)

In Vitro Susceptibility of Aztreonam-Vaborbactam, Aztreonam-Relebactam and Aztreonam-Avibactam Associations against Metallo-β-Lactamase-Producing Gram-Negative Bacteria
by: Cécile Emeraud, et al.
Published: (2023-09-01)

In vitro effectiveness of ceftazidime-avibactam in combination with aztreonam on carbapenemase-producing Enterobacterales
by: Papa-Ezdra Romina, et al.
Published: (2023-12-01)

Clone dissemination of IncX3 plasmid carrying blaNDM-1 in ST76 carbapenem resistance Klebsiella pneumoniae and bactericidal efficiency of aztreonam combined with avibactam in vitro and in vivo
by: Tianqun Huo, et al.
Published: (2024-03-01)

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing
by: Małgorzata Brauncajs, et al.
Published: (2024-03-01)

In Vitro Activities of Ceftazidime–Avibactam and Aztreonam–Avibactam at Different Inoculum Sizes of Extended-Spectrum β-Lactam-Resistant Enterobacterales Blood Isolates
by: Moonsuk Bae, et al.
Published: (2021-12-01)

Ceftazidime-avibactam/aztreonam combination synergy against carbapenem-resistant Gram-negative isolates: In vitro study
by: Reena Rajan, et al.
Published: (2024-01-01)

Ceftazidime-Avibactam plus aztreonam synergistic combination tested against carbapenem-resistant Enterobacterales characterized phenotypically and genotypically: a glimmer of hope
by: Rawan Taha, et al.
Published: (2023-03-01)

Resistance to aztreonam-avibactam due to a mutation of SHV-12 in Enterobacter
by: Shikai Wu, et al.
Published: (2023-06-01)

A simple disk pre-diffusion test to predict in vitro aztreonam/avibactam activity against NDM-producing Klebsiella pneumoniae complex
by: Keila de Oliveira Lima, et al.
Published: (2022-03-01)

Killing Dynamics of Carbapenems against Pseudomonas aeruginosa Harboring Varied Determinants of Carbapenem Resistance
by: Viga Rolly, et al.
Published: (2020-06-01)

Comparative metabolomics reveal key pathways associated with the synergistic activities of aztreonam and clavulanate combination against multidrug-resistant Escherichia coli
by: Jiayuan Zhang, et al.
Published: (2023-12-01)

Effectiveness of empiric aztreonam compared to other beta-lactams for treatment of Pseudomonas aeruginosa infections
by: Hogan M, et al.
Published: (2018-10-01)

Aztreonam: clinical and pharmacological characteristics at the present stage
by: Popov D.A., et al.
Published: (2023-03-01)

Insight into the Interaction Mechanism of HSA with Aztreonam: A Multispectroscopic and Computational Approach
by: Amal A. Sabour, et al.
Published: (2022-11-01)

In Vitro Activity of Auranofin in Combination With Aztreonam-Avibactam Against Metallo-β-lactamase (MBL)-Producing Enterobacterales
by: Wen Wang, et al.
Published: (2021-10-01)

In Vitro Evaluation of the Activity of Aztreonam-Avibactam against 341 Recent Clinical Isolates of Anaerobes
by: David R. Snydman, et al.
Published: (2021-12-01)

Antimicrobial Activity of Aztreonam in Combination with Old and New β-Lactamase Inhibitors against MBL and ESBL Co-Producing Gram-Negative Clinical Isolates: Possible Options for the Treatment of Complicated Infections
by: Gianluca Morroni, et al.
Published: (2021-11-01)

Detecting KPC-2 and NDM-1 Coexpression in Klebsiella pneumoniae Complex from Human and Animal Hosts in South America
by: Felipe Vásquez-Ponce, et al.
Published: (2022-10-01)

In vitro activity of aztreonam–avibactam against metallo-β-lactamase-producing Enterobacteriaceae—A multicenter study in China
by: Biying Zhang, et al.
Published: (2020-08-01)

In vitro efficacy of ceftazidime-avibactam, aztreonam-avibactam and other rescue antibiotics against carbapenem-resistant Enterobacterales from the Arabian Peninsula
by: Ágnes Sonnevend, et al.
Published: (2020-10-01)

In vitro activity of aztreonam-avibactam and comparators against Metallo-β-Lactamase-producing Enterobacterales from ATLAS Global Surveillance Program, 2016–2020
by: Gian Maria Rossolini, et al.
Published: (2024-03-01)

The Revival of Aztreonam in Combination with Avibactam against Metallo-β-Lactamase-Producing Gram-Negatives: A Systematic Review of In Vitro Studies and Clinical Cases
by: Carola Mauri, et al.
Published: (2021-08-01)

Genetic Diversity and in vitro Activity of Aztreonam/Avibactam and Ceftazidime/Avibactam Against Carbapenem-Resistant Enterobacterales: A Multi-Center Study in Southwest China
by: Sun S, et al.
Published: (2022-04-01)

Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Enterobacterales Analyzed by ICU and Non-ICU Wards, Infection Sources, and Geographic Regions: ATLAS Program 2016–2020
by: Denis Piérard, et al.
Published: (2023-11-01)

Epidemiology and Genomic Characteristics of Bloodstream Infection Caused by Carbapenem-Resistant Klebsiella pneumoniae With Decreased Susceptibility to Aztreonam/Avibactam in China
by: Wei Yu, et al.
Published: (2022-06-01)

Aztreonam-avibactam synergy, a validation and comparison of diagnostic tools
by: Gil Verschelden, et al.
Published: (2023-11-01)

In Vivo Pharmacodynamics of β-Lactams/Nacubactam against Carbapenem-Resistant and/or Carbapenemase-Producing <i>Enterobacter cloacae</i> and <i>Klebsiella pneumoniae</i> in Murine Pneumonia Model
by: Mao Hagihara, et al.
Published: (2021-09-01)

A practical laboratory method to determine ceftazidime-avibactam-aztreonam synergy in patients with New Delhi metallo-beta-lactamase (NDM)–producing Enterobacterales infection
by: Timothy Miles Rawson, et al.
Published: (2022-06-01)

In vitro activity of ceftazidime-avibactam, imipenem-relebactam, aztreonam-avibactam, and comparators toward carbapenem-resistant and hypervirulent Klebsiella pneumoniae isolates
by: Dan Li, et al.
Published: (2023-12-01)

In vitro Effect of the Combination of Aztreonam and Amoxicillin/Clavulanic Acid Against Carbapenem-Resistant Gram-Negative Organisms Producing Metallo-β-Lactamase
by: Xu Q, et al.
Published: (2021-03-01)

Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
by: Yanis Merad, et al.
Published: (2023-08-01)

Aztreonam is a novel chemical inducer that promotes Agrobacteium transformation and lateral root development in soybean
by: M. Waqar Khan, et al.
Published: (2023-08-01)

Experimental Design Supported Liposomal Aztreonam Delivery: In Vitro Studies
by: Sayani Bhattacharyya, et al.
Published: (2021-09-01)

Bactericidal Effect of Pterostilbene Alone and in Combination with Gentamicin against Human Pathogenic Bacteria
by: Wee Xian Lee, et al.
Published: (2017-03-01)

In Vitro Activities and Inoculum Effects of Ceftazidime-Avibactam and Aztreonam-Avibactam against Carbapenem-Resistant <i>Enterobacterales</i> Isolates from South Korea
by: Taeeun Kim, et al.
Published: (2020-12-01)

Recent Trends in Prostate Biopsy Complication Rates and the Role of Aztreonam in Periprocedural Antimicrobial Prophylaxis—A Nationwide Population-Based Study from Korea
by: Wook Nam, et al.
Published: (2022-02-01)

In vitro Activity of Ceftazidime-Avibactam and Aztreonam-Avibactam Against Carbapenem-resistant Enterobacteriaceae Isolates Collected from Three Secondary Hospitals in Southwest China Between 2018 and 2019
by: Zou C, et al.
Published: (2020-10-01)

In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase–producing Klebsiella pneumoniae
by: Wenxia Zhang, et al.
Published: (2018-11-01)

Avibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro
by: Qiuxia Lin, et al.
Published: (2021-02-01)