Parelsnoer Institute Biobank Hereditary Colorectal Cancer: A Joint Infrastructure for Patient Data and Biomaterial on Hereditary Colorectal Cancer in the Netherlands
Each year approximately 15,000 patients are diagnosed with colorectal cancer (CRC) in the Netherlands, of whom 5–10% are associated with a hereditary syndrome. To enable future research into hereditary CRC, we established a collaborative biobank for hereditary CRC in all eight University Medical Cen...
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2019-04-01
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| Series: | Open Journal of Bioresources |
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| Online Access: | https://openbioresources.metajnl.com/articles/54 |
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| author | Peggy Manders Janet R. Vos Richarda M. de Voer Liselot P. van Hest Rolf Sijmons Chantal V. Hoge Fokke G. Terpstra Manon C. Spaander Wilma E. Mesker Evelien Dekker Nicoline Hoogerbrugge on behalf of the Biobank Hereditary Colorectal Cancer |
| author_facet | Peggy Manders Janet R. Vos Richarda M. de Voer Liselot P. van Hest Rolf Sijmons Chantal V. Hoge Fokke G. Terpstra Manon C. Spaander Wilma E. Mesker Evelien Dekker Nicoline Hoogerbrugge on behalf of the Biobank Hereditary Colorectal Cancer |
| author_sort | Peggy Manders |
| collection | DOAJ |
| description | Each year approximately 15,000 patients are diagnosed with colorectal cancer (CRC) in the Netherlands, of whom 5–10% are associated with a hereditary syndrome. To enable future research into hereditary CRC, we established a collaborative biobank for hereditary CRC in all eight University Medical Centers (UMCs) in the Netherlands in 2009. This Biobank Hereditary CRC is part of the Parelsnoer Institute (PSI), which is funded by the Dutch Federation of UMCs and the Dutch Government. Besides the multicenter collaboration, the multidisciplinary nature of this biobank – involving Gastroenterology, Genetics and Surgery – is essential for its functionality and value. Patients at increased risk of hereditary CRC and/or Polyposis, or with a proven germline mutation causing CRC and/or Polyposis are included. Both clinical data (demographic data, details on medical and family history, information on surveillance, endoscopy and surgery, results of microsatellite instability and molecular genetic tests) and biomaterial (DNA, plasma, serum and tissue) are collected in a standardized manner. |
| first_indexed | 2024-04-12T11:45:13Z |
| format | Article |
| id | doaj.art-91efb0d449544450a9dbff556c8309b6 |
| institution | Directory Open Access Journal |
| issn | 2056-5542 |
| language | English |
| last_indexed | 2024-04-12T11:45:13Z |
| publishDate | 2019-04-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Open Journal of Bioresources |
| spelling | doaj.art-91efb0d449544450a9dbff556c8309b62022-12-22T03:34:23ZengUbiquity PressOpen Journal of Bioresources2056-55422019-04-01610.5334/ojb.5443Parelsnoer Institute Biobank Hereditary Colorectal Cancer: A Joint Infrastructure for Patient Data and Biomaterial on Hereditary Colorectal Cancer in the NetherlandsPeggy Manders0Janet R. Vos1Richarda M. de Voer2Liselot P. van Hest3Rolf Sijmons4Chantal V. Hoge5Fokke G. Terpstra6Manon C. Spaander7Wilma E. Mesker8Evelien Dekker9Nicoline Hoogerbrugge10on behalf of the Biobank Hereditary Colorectal Cancer11Radboud Biobank, Radboudumc, NijmegenDepartment of Human Genetics, Radboudumc, NijmegenDepartment of Human Genetics, Radboudumc, NijmegenDepartment of Clinical Genetics, VU University Medical Center, AmsterdamDepartment of Genetics, University Medical Center Groningen, University of GroningenDepartment Gastroenterology and Hepatology, Maastricht University Medical Center+, MaastrichtCentral Biobank, University Medical Center Utrecht, UtrechtDepartment of Gastroenterology and Hepatology, Erasmus Medical Center, RotterdamDepartment of Surgery, Leiden University Medical Center, LeidenDepartment of Gastroenterology and Hepatology, Academic Medical Center, AmsterdamDepartment of Human Genetics, Radboudumc, Nijmegen Each year approximately 15,000 patients are diagnosed with colorectal cancer (CRC) in the Netherlands, of whom 5–10% are associated with a hereditary syndrome. To enable future research into hereditary CRC, we established a collaborative biobank for hereditary CRC in all eight University Medical Centers (UMCs) in the Netherlands in 2009. This Biobank Hereditary CRC is part of the Parelsnoer Institute (PSI), which is funded by the Dutch Federation of UMCs and the Dutch Government. Besides the multicenter collaboration, the multidisciplinary nature of this biobank – involving Gastroenterology, Genetics and Surgery – is essential for its functionality and value. Patients at increased risk of hereditary CRC and/or Polyposis, or with a proven germline mutation causing CRC and/or Polyposis are included. Both clinical data (demographic data, details on medical and family history, information on surveillance, endoscopy and surgery, results of microsatellite instability and molecular genetic tests) and biomaterial (DNA, plasma, serum and tissue) are collected in a standardized manner.https://openbioresources.metajnl.com/articles/54Clinical biobankingParelsnoer Institutehereditary colorectal cancerharmonized standardsresearch standards |
| spellingShingle | Peggy Manders Janet R. Vos Richarda M. de Voer Liselot P. van Hest Rolf Sijmons Chantal V. Hoge Fokke G. Terpstra Manon C. Spaander Wilma E. Mesker Evelien Dekker Nicoline Hoogerbrugge on behalf of the Biobank Hereditary Colorectal Cancer Parelsnoer Institute Biobank Hereditary Colorectal Cancer: A Joint Infrastructure for Patient Data and Biomaterial on Hereditary Colorectal Cancer in the Netherlands Open Journal of Bioresources Clinical biobanking Parelsnoer Institute hereditary colorectal cancer harmonized standards research standards |
| title | Parelsnoer Institute Biobank Hereditary Colorectal Cancer: A Joint Infrastructure for Patient Data and Biomaterial on Hereditary Colorectal Cancer in the Netherlands |
| title_full | Parelsnoer Institute Biobank Hereditary Colorectal Cancer: A Joint Infrastructure for Patient Data and Biomaterial on Hereditary Colorectal Cancer in the Netherlands |
| title_fullStr | Parelsnoer Institute Biobank Hereditary Colorectal Cancer: A Joint Infrastructure for Patient Data and Biomaterial on Hereditary Colorectal Cancer in the Netherlands |
| title_full_unstemmed | Parelsnoer Institute Biobank Hereditary Colorectal Cancer: A Joint Infrastructure for Patient Data and Biomaterial on Hereditary Colorectal Cancer in the Netherlands |
| title_short | Parelsnoer Institute Biobank Hereditary Colorectal Cancer: A Joint Infrastructure for Patient Data and Biomaterial on Hereditary Colorectal Cancer in the Netherlands |
| title_sort | parelsnoer institute biobank hereditary colorectal cancer a joint infrastructure for patient data and biomaterial on hereditary colorectal cancer in the netherlands |
| topic | Clinical biobanking Parelsnoer Institute hereditary colorectal cancer harmonized standards research standards |
| url | https://openbioresources.metajnl.com/articles/54 |
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