The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female Rats
Abstract Background: The multiple sclerosis is a chronic disease of the central nervous system. Since the level of sex hormone and multiple sclerosis (MS) disease affects one another, the aim of this study was to evaluate the impact of the hydroalcoholic extract of truffle on the hormone levels of...
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| Format: | Article |
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Arak Medical University
2017-06-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
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| Online Access: | http://amuj.arakmu.ac.ir/article-1-4989-en.pdf |
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| author | Eslam Zabihi Seyed Eghbal Motavallibashi Khayam Bamdad Faegheh Pilevaribadi Hamid Sheikhkanloui Milan |
| author_facet | Eslam Zabihi Seyed Eghbal Motavallibashi Khayam Bamdad Faegheh Pilevaribadi Hamid Sheikhkanloui Milan |
| author_sort | Eslam Zabihi |
| collection | DOAJ |
| description | Abstract
Background: The multiple sclerosis is a chronic disease of the central nervous system. Since the level of sex hormone and multiple sclerosis (MS) disease affects one another, the aim of this study was to evaluate the impact of the hydroalcoholic extract of truffle on the hormone levels of estrogen and progesterone administered in experimental model of MS-induced rats.
Materials and Methods: In this experimental study, 42 Wistar female rats, weighing 180±10 grams selected into 6 groups each consisting of 7 rats. Normal control didn’t receive any treatment and experimental group was given Cuprizone toxin (as a MS model inducer) for 40 days. The experimental groups (2, 3, 4 and 5) in addition to Cuprizone received the normal saline, 110, 220 and 330 mg/kg/0.2ml (i.p.) of Hydroalcoholic extract of truffle for 12 days too. Blood samples were taken at the end of the twelfth day from all groups involved and levels of sex hormones were measured.
Results: Cuprizone decreases estrogen, progesterone levels and also causes weight loss, while injection of hydroalcoholic extract of truffle increased serum levels of estrogen (in experimental group 4) and progesterone (in experimental group 4 & 5) compared to MS-induced group. Conclusion: Results of the study revealed that the hydroalcoholic extract of truffle (at dosages of 220 and 330 mg/kg) could increase estrogen and progesterone levels in rats experienced experimental multiple sclerosis. |
| first_indexed | 2024-12-20T03:06:53Z |
| format | Article |
| id | doaj.art-91f181a1a0174313a897b8aeed887fb7 |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-20T03:06:53Z |
| publishDate | 2017-06-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-91f181a1a0174313a897b8aeed887fb72022-12-21T19:55:34ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2017-06-012034856The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female RatsEslam Zabihi0Seyed Eghbal Motavallibashi1Khayam Bamdad2Faegheh Pilevaribadi3Hamid Sheikhkanloui Milan4MSc Student, Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, IranDepartment of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, IranMSc Student, Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, IranMSc in Midwifery, Department of Midwifery, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, IranAssistant Professor, Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, IranAbstract Background: The multiple sclerosis is a chronic disease of the central nervous system. Since the level of sex hormone and multiple sclerosis (MS) disease affects one another, the aim of this study was to evaluate the impact of the hydroalcoholic extract of truffle on the hormone levels of estrogen and progesterone administered in experimental model of MS-induced rats. Materials and Methods: In this experimental study, 42 Wistar female rats, weighing 180±10 grams selected into 6 groups each consisting of 7 rats. Normal control didn’t receive any treatment and experimental group was given Cuprizone toxin (as a MS model inducer) for 40 days. The experimental groups (2, 3, 4 and 5) in addition to Cuprizone received the normal saline, 110, 220 and 330 mg/kg/0.2ml (i.p.) of Hydroalcoholic extract of truffle for 12 days too. Blood samples were taken at the end of the twelfth day from all groups involved and levels of sex hormones were measured. Results: Cuprizone decreases estrogen, progesterone levels and also causes weight loss, while injection of hydroalcoholic extract of truffle increased serum levels of estrogen (in experimental group 4) and progesterone (in experimental group 4 & 5) compared to MS-induced group. Conclusion: Results of the study revealed that the hydroalcoholic extract of truffle (at dosages of 220 and 330 mg/kg) could increase estrogen and progesterone levels in rats experienced experimental multiple sclerosis.http://amuj.arakmu.ac.ir/article-1-4989-en.pdfEstrogenMultiple sclerosisProgesteroneRatTruffle |
| spellingShingle | Eslam Zabihi Seyed Eghbal Motavallibashi Khayam Bamdad Faegheh Pilevaribadi Hamid Sheikhkanloui Milan The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female Rats Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Estrogen Multiple sclerosis Progesterone Rat Truffle |
| title | The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female Rats |
| title_full | The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female Rats |
| title_fullStr | The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female Rats |
| title_full_unstemmed | The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female Rats |
| title_short | The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female Rats |
| title_sort | effect of hydroalcoholic extract of truffle on estrogen and progesterone levels in experimental model of multiple sclerosis ms in female rats |
| topic | Estrogen Multiple sclerosis Progesterone Rat Truffle |
| url | http://amuj.arakmu.ac.ir/article-1-4989-en.pdf |
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