Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Proteomics can be used to refine cancer classification. Here, the authors characterise chronic lymphocytic leukaemia patients by proteogenomics, and identified a subtype of patients with poor prognosis associated with aberrant B cell receptor signalling.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33385-8 |
| _version_ | 1798028540899229696 |
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| author | Sophie A. Herbst Mattias Vesterlund Alexander J. Helmboldt Rozbeh Jafari Ioannis Siavelis Matthias Stahl Eva C. Schitter Nora Liebers Berit J. Brinkmann Felix Czernilofsky Tobias Roider Peter-Martin Bruch Murat Iskar Adam Kittai Ying Huang Junyan Lu Sarah Richter Georgios Mermelekas Husen Muhammad Umer Mareike Knoll Carolin Kolb Angela Lenze Xiaofang Cao Cecilia Österholm Linus Wahnschaffe Carmen Herling Sebastian Scheinost Matthias Ganzinger Larry Mansouri Katharina Kriegsmann Mark Kriegsmann Simon Anders Marc Zapatka Giovanni Del Poeta Antonella Zucchetto Riccardo Bomben Valter Gattei Peter Dreger Jennifer Woyach Marco Herling Carsten Müller-Tidow Richard Rosenquist Stephan Stilgenbauer Thorsten Zenz Wolfgang Huber Eugen Tausch Janne Lehtiö Sascha Dietrich |
| author_facet | Sophie A. Herbst Mattias Vesterlund Alexander J. Helmboldt Rozbeh Jafari Ioannis Siavelis Matthias Stahl Eva C. Schitter Nora Liebers Berit J. Brinkmann Felix Czernilofsky Tobias Roider Peter-Martin Bruch Murat Iskar Adam Kittai Ying Huang Junyan Lu Sarah Richter Georgios Mermelekas Husen Muhammad Umer Mareike Knoll Carolin Kolb Angela Lenze Xiaofang Cao Cecilia Österholm Linus Wahnschaffe Carmen Herling Sebastian Scheinost Matthias Ganzinger Larry Mansouri Katharina Kriegsmann Mark Kriegsmann Simon Anders Marc Zapatka Giovanni Del Poeta Antonella Zucchetto Riccardo Bomben Valter Gattei Peter Dreger Jennifer Woyach Marco Herling Carsten Müller-Tidow Richard Rosenquist Stephan Stilgenbauer Thorsten Zenz Wolfgang Huber Eugen Tausch Janne Lehtiö Sascha Dietrich |
| author_sort | Sophie A. Herbst |
| collection | DOAJ |
| description | Proteomics can be used to refine cancer classification. Here, the authors characterise chronic lymphocytic leukaemia patients by proteogenomics, and identified a subtype of patients with poor prognosis associated with aberrant B cell receptor signalling. |
| first_indexed | 2024-04-11T19:09:57Z |
| format | Article |
| id | doaj.art-91f1d089720c4b3a86f1c0a1195a3faa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T19:09:57Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-91f1d089720c4b3a86f1c0a1195a3faa2022-12-22T04:07:39ZengNature PortfolioNature Communications2041-17232022-10-0113111810.1038/s41467-022-33385-8Proteogenomics refines the molecular classification of chronic lymphocytic leukemiaSophie A. Herbst0Mattias Vesterlund1Alexander J. Helmboldt2Rozbeh Jafari3Ioannis Siavelis4Matthias Stahl5Eva C. Schitter6Nora Liebers7Berit J. Brinkmann8Felix Czernilofsky9Tobias Roider10Peter-Martin Bruch11Murat Iskar12Adam Kittai13Ying Huang14Junyan Lu15Sarah Richter16Georgios Mermelekas17Husen Muhammad Umer18Mareike Knoll19Carolin Kolb20Angela Lenze21Xiaofang Cao22Cecilia Österholm23Linus Wahnschaffe24Carmen Herling25Sebastian Scheinost26Matthias Ganzinger27Larry Mansouri28Katharina Kriegsmann29Mark Kriegsmann30Simon Anders31Marc Zapatka32Giovanni Del Poeta33Antonella Zucchetto34Riccardo Bomben35Valter Gattei36Peter Dreger37Jennifer Woyach38Marco Herling39Carsten Müller-Tidow40Richard Rosenquist41Stephan Stilgenbauer42Thorsten Zenz43Wolfgang Huber44Eugen Tausch45Janne Lehtiö46Sascha Dietrich47Department of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Oncology-Pathology, Karolinska Institute and Science for Life LaboratoryEuropean Molecular Biology Laboratory (EMBL)Department of Oncology-Pathology, Karolinska Institute and Science for Life LaboratoryDepartment of Oncology-Pathology, Karolinska Institute and Science for Life LaboratoryDepartment of Oncology-Pathology, Karolinska Institute and Science for Life LaboratoryDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDivision of Molecular Genetics, German Cancer Research Center (DKFZ)Department of Internal Medicine, Division of Hematology, The Ohio State UniversityDepartment of Internal Medicine, Division of Hematology, The Ohio State UniversityEuropean Molecular Biology Laboratory (EMBL)Department of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Oncology-Pathology, Karolinska Institute and Science for Life LaboratoryDepartment of Oncology-Pathology, Karolinska Institute and Science for Life LaboratoryDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Oncology-Pathology, Karolinska Institute and Science for Life LaboratoryDepartment of Molecular Medicine and Surgery, Karolinska InstitutetDepartment I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf (CIO ABCD), Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of CologneDepartment I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf (CIO ABCD), Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of CologneDepartment of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)Institute of Medical Biometry and Informatics, Heidelberg UniversityDepartment of Molecular Medicine and Surgery, Karolinska InstitutetDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergInstitute of Pathology, University of HeidelbergCenter for Molecular Biology of the University of Heidelberg (ZMBH)Division of Molecular Genetics, German Cancer Research Center (DKFZ)Division of Hematology, University of Tor VergataClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCSClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCSClinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCSDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Internal Medicine, Division of Hematology, The Ohio State UniversityDepartment I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf (CIO ABCD), Excellence Cluster for Cellular Stress Response and Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of CologneDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergDepartment of Molecular Medicine and Surgery, Karolinska InstitutetDepartment of Internal Medicine III, University of UlmDepartment of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)European Molecular Biology Laboratory (EMBL)Department of Internal Medicine III, University of UlmDepartment of Oncology-Pathology, Karolinska Institute and Science for Life LaboratoryDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of HeidelbergProteomics can be used to refine cancer classification. Here, the authors characterise chronic lymphocytic leukaemia patients by proteogenomics, and identified a subtype of patients with poor prognosis associated with aberrant B cell receptor signalling.https://doi.org/10.1038/s41467-022-33385-8 |
| spellingShingle | Sophie A. Herbst Mattias Vesterlund Alexander J. Helmboldt Rozbeh Jafari Ioannis Siavelis Matthias Stahl Eva C. Schitter Nora Liebers Berit J. Brinkmann Felix Czernilofsky Tobias Roider Peter-Martin Bruch Murat Iskar Adam Kittai Ying Huang Junyan Lu Sarah Richter Georgios Mermelekas Husen Muhammad Umer Mareike Knoll Carolin Kolb Angela Lenze Xiaofang Cao Cecilia Österholm Linus Wahnschaffe Carmen Herling Sebastian Scheinost Matthias Ganzinger Larry Mansouri Katharina Kriegsmann Mark Kriegsmann Simon Anders Marc Zapatka Giovanni Del Poeta Antonella Zucchetto Riccardo Bomben Valter Gattei Peter Dreger Jennifer Woyach Marco Herling Carsten Müller-Tidow Richard Rosenquist Stephan Stilgenbauer Thorsten Zenz Wolfgang Huber Eugen Tausch Janne Lehtiö Sascha Dietrich Proteogenomics refines the molecular classification of chronic lymphocytic leukemia Nature Communications |
| title | Proteogenomics refines the molecular classification of chronic lymphocytic leukemia |
| title_full | Proteogenomics refines the molecular classification of chronic lymphocytic leukemia |
| title_fullStr | Proteogenomics refines the molecular classification of chronic lymphocytic leukemia |
| title_full_unstemmed | Proteogenomics refines the molecular classification of chronic lymphocytic leukemia |
| title_short | Proteogenomics refines the molecular classification of chronic lymphocytic leukemia |
| title_sort | proteogenomics refines the molecular classification of chronic lymphocytic leukemia |
| url | https://doi.org/10.1038/s41467-022-33385-8 |
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