Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT
Aim: This study aims to evaluate the safety and efficacy of fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG-PET/CT) guided intensity-modulated radiation therapy (IMRT) for patients with peritoneal metastases. Patients and Methods: A total of 55 patients with peritoneal...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-09-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/1533033820960723 |
| _version_ | 1818508681320333312 |
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| author | Ya-Zheng Dang MD Dong-Xian Zhang MS Guo-Dong Wang MS Hong-Liang Zhao MS Shi-Gao Huang PhD Jie Li BS |
| author_facet | Ya-Zheng Dang MD Dong-Xian Zhang MS Guo-Dong Wang MS Hong-Liang Zhao MS Shi-Gao Huang PhD Jie Li BS |
| author_sort | Ya-Zheng Dang MD |
| collection | DOAJ |
| description | Aim: This study aims to evaluate the safety and efficacy of fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG-PET/CT) guided intensity-modulated radiation therapy (IMRT) for patients with peritoneal metastases. Patients and Methods: A total of 55 patients with peritoneal metastases were treated with 18F-FDG-PET/CT-guided IMRT (BIMRT) from January 2012 to January 2019. They were prescribed with a fraction of the median dose of 2 Gy to a total dose of 50.4 Gy. The multivariate analysis was used the Cox proportional hazard model and the Kaplan-Meier plot was used to perform local control rate (LCR), progression-free survival (PFS), and overall survival (OS) analysis. Results: The 1-year, 2-year, and 3-year LCR were 72.7%, 36.4%, and 9.1%, respectively; the 1-year, 2-year, and 3-year PFS were 69.1%, 30.9%, and 7.3%, respectively, and the median PFS time was 18 months. The 1-year, 3-year and 5-year OS were 70.9%, 28.7%, and 4.2%, respectively. Based on the multivariate analysis using the Cox proportional hazard model, the Karnofsky performance status (KPS) score and radiotherapy joint chemotherapy (RJC) method were independent prognostic-related indicators (P < 0.0001). Conclusion: BIMRT may be a safe and effective treatment for patients with peritoneal metastases, especially for patients who cannot undergo surgery. In addition, the results indicated that the patient’s KPS score and RJC method were independent prognostic-related indicators for patients survival time. |
| first_indexed | 2024-12-10T22:35:22Z |
| format | Article |
| id | doaj.art-91f3369d45c347b994f200d861f3e948 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-12-10T22:35:22Z |
| publishDate | 2020-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-91f3369d45c347b994f200d861f3e9482022-12-22T01:30:56ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-09-011910.1177/1533033820960723Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CTYa-Zheng Dang MD0Dong-Xian Zhang MS1Guo-Dong Wang MS2Hong-Liang Zhao MS3Shi-Gao Huang PhD4Jie Li BS5 Department of Radiation Oncology, 986 Hospital of People’s Liberation Army Air Force, Xi’an, Shaanxi, Province, China Department of Radiation Oncology, 986 Hospital of People’s Liberation Army Air Force, Xi’an, Shaanxi, Province, China Department of Radiation Oncology, 986 Hospital of People’s Liberation Army Air Force, Xi’an, Shaanxi, Province, China Department of Radiation Oncology, 986 Hospital of People’s Liberation Army Air Force, Xi’an, Shaanxi, Province, China Cancer Center, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macao SAR, People’s Republic of China Department of Obstetrics and Gynecology, Taizhou Hospital of Zhejiang Province, Taizhou Enze Medical Center (Group), Linhai, Zhejiang Province, ChinaAim: This study aims to evaluate the safety and efficacy of fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG-PET/CT) guided intensity-modulated radiation therapy (IMRT) for patients with peritoneal metastases. Patients and Methods: A total of 55 patients with peritoneal metastases were treated with 18F-FDG-PET/CT-guided IMRT (BIMRT) from January 2012 to January 2019. They were prescribed with a fraction of the median dose of 2 Gy to a total dose of 50.4 Gy. The multivariate analysis was used the Cox proportional hazard model and the Kaplan-Meier plot was used to perform local control rate (LCR), progression-free survival (PFS), and overall survival (OS) analysis. Results: The 1-year, 2-year, and 3-year LCR were 72.7%, 36.4%, and 9.1%, respectively; the 1-year, 2-year, and 3-year PFS were 69.1%, 30.9%, and 7.3%, respectively, and the median PFS time was 18 months. The 1-year, 3-year and 5-year OS were 70.9%, 28.7%, and 4.2%, respectively. Based on the multivariate analysis using the Cox proportional hazard model, the Karnofsky performance status (KPS) score and radiotherapy joint chemotherapy (RJC) method were independent prognostic-related indicators (P < 0.0001). Conclusion: BIMRT may be a safe and effective treatment for patients with peritoneal metastases, especially for patients who cannot undergo surgery. In addition, the results indicated that the patient’s KPS score and RJC method were independent prognostic-related indicators for patients survival time.https://doi.org/10.1177/1533033820960723 |
| spellingShingle | Ya-Zheng Dang MD Dong-Xian Zhang MS Guo-Dong Wang MS Hong-Liang Zhao MS Shi-Gao Huang PhD Jie Li BS Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT Technology in Cancer Research & Treatment |
| title | Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT |
| title_full | Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT |
| title_fullStr | Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT |
| title_full_unstemmed | Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT |
| title_short | Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT |
| title_sort | safety and efficacy of the metabolic profiling of the bimrt utilizing 18f fdg pet ct |
| url | https://doi.org/10.1177/1533033820960723 |
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