Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits.
The impact of sub-concussive head hits (sub-CHIs) has been recently investigated in American football players, a population at risk for varying degrees of post-traumatic sequelae. Results show how sub-CHIs in athletes translate in serum as the appearance of reporters of blood-brain barrier disruptio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4012998?pdf=render |
| _version_ | 1818033302803578880 |
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| author | Vikram Puvenna Chanda Brennan Gerald Shaw Cui Yang Nicola Marchi Jeffrey J Bazarian Kian Merchant-Borna Damir Janigro |
| author_facet | Vikram Puvenna Chanda Brennan Gerald Shaw Cui Yang Nicola Marchi Jeffrey J Bazarian Kian Merchant-Borna Damir Janigro |
| author_sort | Vikram Puvenna |
| collection | DOAJ |
| description | The impact of sub-concussive head hits (sub-CHIs) has been recently investigated in American football players, a population at risk for varying degrees of post-traumatic sequelae. Results show how sub-CHIs in athletes translate in serum as the appearance of reporters of blood-brain barrier disruption (BBBD), how the number and severity of sub-CHIs correlate with elevations of putative markers of brain injury is unknown. Serum brain injury markers such as UCH-L1 depend on BBBD. We investigated the effects of sub-CHIs in collegiate football players on markers of BBBD, markers of cerebrospinal fluid leakage (serum beta 2-transferrin) and markers of brain damage. Emergency room patients admitted for a clinically-diagnosed mild traumatic brain injury (mTBI) were used as positive controls. Healthy volunteers were used as negative controls. Specifically this study was designed to determine the use of UCH-L1 as an aid in the diagnosis of sub-concussive head injury in athletes. The extent and intensity of head impacts and serum values of S100B, UCH-L1, and beta-2 transferrin were measured pre- and post-game from 15 college football players who did not experience a concussion after a game. S100B was elevated in players experiencing the most sub-CHIs; UCH-L1 levels were also elevated but did not correlate with S100B or sub-CHIs. Beta-2 transferrin levels remained unchanged. No correlation between UCH-L1 levels and mTBI were measured in patients. Low levels of S100B were able to rule out mTBI and high S100B levels correlated with TBI severity. UCH-L1 did not display any interpretable change in football players or in individuals with mild TBI. The significance of UCH-L1 changes in sub-concussions or mTBI needs to be further elucidated. |
| first_indexed | 2024-12-10T06:21:07Z |
| format | Article |
| id | doaj.art-91f4a12cb29748d4a720c16687076d1d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T06:21:07Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-91f4a12cb29748d4a720c16687076d1d2022-12-22T01:59:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9629610.1371/journal.pone.0096296Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits.Vikram PuvennaChanda BrennanGerald ShawCui YangNicola MarchiJeffrey J BazarianKian Merchant-BornaDamir JanigroThe impact of sub-concussive head hits (sub-CHIs) has been recently investigated in American football players, a population at risk for varying degrees of post-traumatic sequelae. Results show how sub-CHIs in athletes translate in serum as the appearance of reporters of blood-brain barrier disruption (BBBD), how the number and severity of sub-CHIs correlate with elevations of putative markers of brain injury is unknown. Serum brain injury markers such as UCH-L1 depend on BBBD. We investigated the effects of sub-CHIs in collegiate football players on markers of BBBD, markers of cerebrospinal fluid leakage (serum beta 2-transferrin) and markers of brain damage. Emergency room patients admitted for a clinically-diagnosed mild traumatic brain injury (mTBI) were used as positive controls. Healthy volunteers were used as negative controls. Specifically this study was designed to determine the use of UCH-L1 as an aid in the diagnosis of sub-concussive head injury in athletes. The extent and intensity of head impacts and serum values of S100B, UCH-L1, and beta-2 transferrin were measured pre- and post-game from 15 college football players who did not experience a concussion after a game. S100B was elevated in players experiencing the most sub-CHIs; UCH-L1 levels were also elevated but did not correlate with S100B or sub-CHIs. Beta-2 transferrin levels remained unchanged. No correlation between UCH-L1 levels and mTBI were measured in patients. Low levels of S100B were able to rule out mTBI and high S100B levels correlated with TBI severity. UCH-L1 did not display any interpretable change in football players or in individuals with mild TBI. The significance of UCH-L1 changes in sub-concussions or mTBI needs to be further elucidated.http://europepmc.org/articles/PMC4012998?pdf=render |
| spellingShingle | Vikram Puvenna Chanda Brennan Gerald Shaw Cui Yang Nicola Marchi Jeffrey J Bazarian Kian Merchant-Borna Damir Janigro Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. PLoS ONE |
| title | Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. |
| title_full | Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. |
| title_fullStr | Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. |
| title_full_unstemmed | Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. |
| title_short | Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. |
| title_sort | significance of ubiquitin carboxy terminal hydrolase l1 elevations in athletes after sub concussive head hits |
| url | http://europepmc.org/articles/PMC4012998?pdf=render |
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