Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy

Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy

Abstract Osteoarthritis (OA) is a prevalent joint disease that affects all the tissues within the joint and currently lacks disease-modifying treatments in clinical practice. Despite the potential of rapamycin for OA disease alleviation, its clinical application is hindered by the challenge of achie...

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Bibliographic Details
Main Authors: Jian-Chao Ma, Tingting Luo, Binyang Feng, Zicheng Huang, Yiqing Zhang, Hanqing Huang, Xiao Yang, Jing Wen, Xiaochun Bai, Zhong-Kai Cui
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Nanobiotechnology
Subjects:
PLGA nanoparticles
Rapamycin
Intra-articular injection
mTORC1
Osteoarthritis therapy
Online Access:https://doi.org/10.1186/s12951-023-02118-4

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