Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort
A small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a significant risk factor for common diseases in elderly pop...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/4/1056 |
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| author | Celeste Ferraris Alexandria Turner Kiranjit Kaur Jessica Piper Martin Veysey Mark Lucock Emma L. Beckett |
| author_facet | Celeste Ferraris Alexandria Turner Kiranjit Kaur Jessica Piper Martin Veysey Mark Lucock Emma L. Beckett |
| author_sort | Celeste Ferraris |
| collection | DOAJ |
| description | A small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a significant risk factor for common diseases in elderly populations such as hypertension and cardiovascular disease; however, this does not fully explain the risk. Research into the influence of salt taste genetics on diet quality is yet to be undertaken and current research on indicators of health is limited and mixed in the direction of associations. Therefore, a secondary analysis of data from a well-characterised elderly cohort (the cross-sectional Retirement Health and Lifestyle Study, <i>n</i> = 536) was conducted to explore relationships between the salt taste-related SNP <i>TRPV1</i>-rs8065080 (assessed by Taqman genotyping assay), dietary habits and biomarkers of health. Data were analysed with standard least squares regression modelling and Tukey’s HSD post hoc tests. No association was found between the <i>TRPV1</i>-rs8065080 genotype, sodium intake or multiple diet quality indices (assessed by food frequency questionnaire). Sodium-related markers of health including blood pressure and markers of kidney function (urinary creatinine and albumin/creatinine ratio) and general health markers, such as Body Mass Index (BMI), were also not related to <i>TRPV1</i>-rs8065080 genotype. To date, this study is the most comprehensive investigation conducted to determine if the <i>TRPV1</i>-rs8065080 genotype relates to sodium intake and health markers influenced by sodium intake. Although no significant relationships were found, these findings are an important contribution to the limited body of knowledge surround this SNP. In addition to further research across other ages and cultures, the <i>TRPV1</i>-rs8065080 genotype may interact with other ion channels, and so further studies are required to determine if polymorphic variations influence sodium intake, diet and health. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:32:04Z |
| publishDate | 2020-04-01 |
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| series | Nutrients |
| spelling | doaj.art-91f54b101aee4785813119e1aeba5d4d2023-11-19T21:18:17ZengMDPI AGNutrients2072-66432020-04-01124105610.3390/nu12041056Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly CohortCeleste Ferraris0Alexandria Turner1Kiranjit Kaur2Jessica Piper3Martin Veysey4Mark Lucock5Emma L. Beckett6School of Environmental and Life Sciences, The University of Newcastle, Ourimbah, NSW 2258, AustraliaSchool of Environmental and Life Sciences, The University of Newcastle, Ourimbah, NSW 2258, AustraliaSchool of Environmental and Life Sciences, The University of Newcastle, Ourimbah, NSW 2258, AustraliaSchool of Environmental and Life Sciences, The University of Newcastle, Ourimbah, NSW 2258, AustraliaSchool of Medicine and Public Health, The University of Newcastle, Gosford, NSW 2250, AustraliaSchool of Environmental and Life Sciences, The University of Newcastle, Ourimbah, NSW 2258, AustraliaSchool of Environmental and Life Sciences, The University of Newcastle, Ourimbah, NSW 2258, AustraliaA small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a significant risk factor for common diseases in elderly populations such as hypertension and cardiovascular disease; however, this does not fully explain the risk. Research into the influence of salt taste genetics on diet quality is yet to be undertaken and current research on indicators of health is limited and mixed in the direction of associations. Therefore, a secondary analysis of data from a well-characterised elderly cohort (the cross-sectional Retirement Health and Lifestyle Study, <i>n</i> = 536) was conducted to explore relationships between the salt taste-related SNP <i>TRPV1</i>-rs8065080 (assessed by Taqman genotyping assay), dietary habits and biomarkers of health. Data were analysed with standard least squares regression modelling and Tukey’s HSD post hoc tests. No association was found between the <i>TRPV1</i>-rs8065080 genotype, sodium intake or multiple diet quality indices (assessed by food frequency questionnaire). Sodium-related markers of health including blood pressure and markers of kidney function (urinary creatinine and albumin/creatinine ratio) and general health markers, such as Body Mass Index (BMI), were also not related to <i>TRPV1</i>-rs8065080 genotype. To date, this study is the most comprehensive investigation conducted to determine if the <i>TRPV1</i>-rs8065080 genotype relates to sodium intake and health markers influenced by sodium intake. Although no significant relationships were found, these findings are an important contribution to the limited body of knowledge surround this SNP. In addition to further research across other ages and cultures, the <i>TRPV1</i>-rs8065080 genotype may interact with other ion channels, and so further studies are required to determine if polymorphic variations influence sodium intake, diet and health.https://www.mdpi.com/2072-6643/12/4/1056salttaste<i>TRPV1</i> geners806500dietarybiomarker |
| spellingShingle | Celeste Ferraris Alexandria Turner Kiranjit Kaur Jessica Piper Martin Veysey Mark Lucock Emma L. Beckett Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort Nutrients salt taste <i>TRPV1</i> gene rs806500 dietary biomarker |
| title | Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort |
| title_full | Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort |
| title_fullStr | Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort |
| title_full_unstemmed | Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort |
| title_short | Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort |
| title_sort | salt taste genotype dietary habits and biomarkers of health no associations in an elderly cohort |
| topic | salt taste <i>TRPV1</i> gene rs806500 dietary biomarker |
| url | https://www.mdpi.com/2072-6643/12/4/1056 |
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