Sativa seeds against Schistosoma mansoni different stages
The schistosomicidal properties of Nigella sativaseeds were tested in vitro against Schistosoma mansoni miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2005-04-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000200016 |
| _version_ | 1797756516765270016 |
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| author | Azza M Mohamed Nadia M Metwally Sohair S Mahmoud |
| author_facet | Azza M Mohamed Nadia M Metwally Sohair S Mahmoud |
| author_sort | Azza M Mohamed |
| collection | DOAJ |
| description | The schistosomicidal properties of Nigella sativaseeds were tested in vitro against Schistosoma mansoni miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In the present work we also studied the effects of crushed seeds on some antioxidant enzymes; which have a role in protection of adult worms against host oxidant killing; as well as some enzymes of glucose metabolism; which have a crucial role in the survival of adult worms inside their hosts. The data revealed that the used drug induce an oxidative stress against adult worms which indicated by a decrease in the activities of both antioxidant enzymes, superoxide dismutase, glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of such enzymes of adult worms using N. sativa seeds could in turn render the parasite vulnerable to damage by the host and may play a role in the antischistosomal potency of the used drug. |
| first_indexed | 2024-03-12T18:02:38Z |
| format | Article |
| id | doaj.art-91f581304b9449649d1e1647f9e390f3 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:02:38Z |
| publishDate | 2005-04-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-91f581304b9449649d1e1647f9e390f32023-08-02T09:36:20ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602005-04-01100220521110.1590/S0074-02762005000200016Sativa seeds against Schistosoma mansoni different stagesAzza M MohamedNadia M MetwallySohair S MahmoudThe schistosomicidal properties of Nigella sativaseeds were tested in vitro against Schistosoma mansoni miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In the present work we also studied the effects of crushed seeds on some antioxidant enzymes; which have a role in protection of adult worms against host oxidant killing; as well as some enzymes of glucose metabolism; which have a crucial role in the survival of adult worms inside their hosts. The data revealed that the used drug induce an oxidative stress against adult worms which indicated by a decrease in the activities of both antioxidant enzymes, superoxide dismutase, glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of such enzymes of adult worms using N. sativa seeds could in turn render the parasite vulnerable to damage by the host and may play a role in the antischistosomal potency of the used drug.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000200016Nigella sativaSchistosoma mansonimiracidiacercariaeadult wormsantioxidant enzymesglucose metabolism |
| spellingShingle | Azza M Mohamed Nadia M Metwally Sohair S Mahmoud Sativa seeds against Schistosoma mansoni different stages Memorias do Instituto Oswaldo Cruz Nigella sativa Schistosoma mansoni miracidia cercariae adult worms antioxidant enzymes glucose metabolism |
| title | Sativa seeds against Schistosoma mansoni different stages |
| title_full | Sativa seeds against Schistosoma mansoni different stages |
| title_fullStr | Sativa seeds against Schistosoma mansoni different stages |
| title_full_unstemmed | Sativa seeds against Schistosoma mansoni different stages |
| title_short | Sativa seeds against Schistosoma mansoni different stages |
| title_sort | sativa seeds against schistosoma mansoni different stages |
| topic | Nigella sativa Schistosoma mansoni miracidia cercariae adult worms antioxidant enzymes glucose metabolism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000200016 |
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