The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells

The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells

Abstract CD8+ T cells play an important role in anti-tumor immunity. Better understanding of their regulation could advance cancer immunotherapies. Here we identify, via stepwise CRISPR-based screening, that CUL5 is a negative regulator of the core signaling pathways of CD8+ T cells. Knocking out CU...

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Bibliographic Details
Main Authors: Xiaofeng Liao, Wenxue Li, Hongyue Zhou, Barani Kumar Rajendran, Ao Li, Jingjing Ren, Yi Luan, David A. Calderwood, Benjamin Turk, Wenwen Tang, Yansheng Liu, Dianqing Wu
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44885-0

Internet

https://doi.org/10.1038/s41467-024-44885-0

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