Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure
In this study, a novel pH/temperature sensitive hydrogel bead with core-shelled structure, composed of calcium alginate (Ca-alginate) and poly((N-acryloylglycine) (PAG), was prepared using as a drug delivery system. The equilibrium swelling has indicated the distinct sensitivities of the beads to pH...
| Format: | Article |
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| Language: | English |
| Published: |
Budapest University of Technology
2010-12-01
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| Series: | eXPRESS Polymer Letters |
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| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0001696&mi=cd |
| _version_ | 1811315790427717632 |
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| collection | DOAJ |
| description | In this study, a novel pH/temperature sensitive hydrogel bead with core-shelled structure, composed of calcium alginate (Ca-alginate) and poly((N-acryloylglycine) (PAG), was prepared using as a drug delivery system. The equilibrium swelling has indicated the distinct sensitivities of the beads to pH value and temperature. In pH = 7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the core of the beads was about 83.5% within 650 min, whereas this value only reached 16.6% in pH = 2.1 PBS. In addition, the release rate of indomethacin was much faster at 37°C than that at 24°C. The experimental results have showed that the Ca-alginate/PAG beads have a potential application for the pH/temperature-controlled drug release carrier in the biomedical field. |
| first_indexed | 2024-04-13T11:37:43Z |
| format | Article |
| id | doaj.art-91fc36466b3c4bf1bafd7f8760332963 |
| institution | Directory Open Access Journal |
| issn | 1788-618X |
| language | English |
| last_indexed | 2024-04-13T11:37:43Z |
| publishDate | 2010-12-01 |
| publisher | Budapest University of Technology |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj.art-91fc36466b3c4bf1bafd7f87603329632022-12-22T02:48:25ZengBudapest University of TechnologyeXPRESS Polymer Letters1788-618X2010-12-0141277378010.3144/expresspolymlett.2010.93Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structureIn this study, a novel pH/temperature sensitive hydrogel bead with core-shelled structure, composed of calcium alginate (Ca-alginate) and poly((N-acryloylglycine) (PAG), was prepared using as a drug delivery system. The equilibrium swelling has indicated the distinct sensitivities of the beads to pH value and temperature. In pH = 7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the core of the beads was about 83.5% within 650 min, whereas this value only reached 16.6% in pH = 2.1 PBS. In addition, the release rate of indomethacin was much faster at 37°C than that at 24°C. The experimental results have showed that the Ca-alginate/PAG beads have a potential application for the pH/temperature-controlled drug release carrier in the biomedical field.http://www.expresspolymlett.com/letolt.php?file=EPL-0001696&mi=cdSmart polymersdrug releasecore-shelled beadpH/temperature sensitive |
| spellingShingle | Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure eXPRESS Polymer Letters Smart polymers drug release core-shelled bead pH/temperature sensitive |
| title | Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure |
| title_full | Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure |
| title_fullStr | Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure |
| title_full_unstemmed | Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure |
| title_short | Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure |
| title_sort | drug release behavior of a ph temperature sensitive calcium alginate poly n acryloylglycine bead with core shelled structure |
| topic | Smart polymers drug release core-shelled bead pH/temperature sensitive |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0001696&mi=cd |