Organismal Roles of Hsp90
Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that assists in the maturation of many client proteins involved in cellular signal transduction. As a regulator of cellular signaling processes, it is vital for the maintenance of cellular proteostasis and adaptation to environm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/2/251 |
| _version_ | 1827758326612492288 |
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| author | Patricija van Oosten-Hawle |
| author_facet | Patricija van Oosten-Hawle |
| author_sort | Patricija van Oosten-Hawle |
| collection | DOAJ |
| description | Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that assists in the maturation of many client proteins involved in cellular signal transduction. As a regulator of cellular signaling processes, it is vital for the maintenance of cellular proteostasis and adaptation to environmental stresses. Emerging research shows that Hsp90 function in an organism goes well beyond intracellular proteostasis. In metazoans, Hsp90, as an environmentally responsive chaperone, is involved in inter-tissue stress signaling responses that coordinate and safeguard cell nonautonomous proteostasis and organismal health. In this way, Hsp90 has the capacity to influence evolution and aging, and effect behavioral responses to facilitate tissue-defense systems that ensure organismal survival. In this review, I summarize the literature on the organismal roles of Hsp90 uncovered in multicellular organisms, from plants to invertebrates and mammals. |
| first_indexed | 2024-03-11T09:06:06Z |
| format | Article |
| id | doaj.art-91fc8439cd8541c49054729e44bde5cf |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T09:06:06Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-91fc8439cd8541c49054729e44bde5cf2023-11-16T19:22:30ZengMDPI AGBiomolecules2218-273X2023-01-0113225110.3390/biom13020251Organismal Roles of Hsp90Patricija van Oosten-Hawle0Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223, USAHeat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that assists in the maturation of many client proteins involved in cellular signal transduction. As a regulator of cellular signaling processes, it is vital for the maintenance of cellular proteostasis and adaptation to environmental stresses. Emerging research shows that Hsp90 function in an organism goes well beyond intracellular proteostasis. In metazoans, Hsp90, as an environmentally responsive chaperone, is involved in inter-tissue stress signaling responses that coordinate and safeguard cell nonautonomous proteostasis and organismal health. In this way, Hsp90 has the capacity to influence evolution and aging, and effect behavioral responses to facilitate tissue-defense systems that ensure organismal survival. In this review, I summarize the literature on the organismal roles of Hsp90 uncovered in multicellular organisms, from plants to invertebrates and mammals.https://www.mdpi.com/2218-273X/13/2/251Hsp90organismalcell nonautonomousproteostasisstress responseinter-tissue stress signaling |
| spellingShingle | Patricija van Oosten-Hawle Organismal Roles of Hsp90 Biomolecules Hsp90 organismal cell nonautonomous proteostasis stress response inter-tissue stress signaling |
| title | Organismal Roles of Hsp90 |
| title_full | Organismal Roles of Hsp90 |
| title_fullStr | Organismal Roles of Hsp90 |
| title_full_unstemmed | Organismal Roles of Hsp90 |
| title_short | Organismal Roles of Hsp90 |
| title_sort | organismal roles of hsp90 |
| topic | Hsp90 organismal cell nonautonomous proteostasis stress response inter-tissue stress signaling |
| url | https://www.mdpi.com/2218-273X/13/2/251 |
| work_keys_str_mv | AT patricijavanoostenhawle organismalrolesofhsp90 |