Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet
This study was designed to evaluate a polyphenols-rich fruit-based functional beverage on blood pressure, serum and liver lipid profiles in vivo. Sixty spontaneously hypertensive rats were divided into five groups and were fed with a AIN-93G-diet as the normal control (NC), high cholesterol diet as...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-07-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464613001345 |
| _version_ | 1818408725170356224 |
|---|---|
| author | K.D.P.P. Gunathilake Y. Wang H.P. Vasantha Rupasinghe |
| author_facet | K.D.P.P. Gunathilake Y. Wang H.P. Vasantha Rupasinghe |
| author_sort | K.D.P.P. Gunathilake |
| collection | DOAJ |
| description | This study was designed to evaluate a polyphenols-rich fruit-based functional beverage on blood pressure, serum and liver lipid profiles in vivo. Sixty spontaneously hypertensive rats were divided into five groups and were fed with a AIN-93G-diet as the normal control (NC), high cholesterol diet as atherogenic control (AC), and the AC diet with three different beverage dosages (0.5X, 1X, 2X), where X is the equivalence of two portion sizes for an adult (X = 10 mL/kg BW/day) after dose translation. Blood pressure was measured during weeks 2 and 4 using a tail-cuff method. Systolic blood pressures were lowered by the beverage at the supplementation of 1X/2X after 2 week but not after 4 week. The oral administration of the beverage at 1X/2X significantly lowered liver cholesterol and total and non-HDL-cholesterol levels in the serum. Thus, the newly formulated beverage possessed hypolipidaemic effects while showing inconsistent effect in lowering the blood pressure. |
| first_indexed | 2024-12-14T09:48:17Z |
| format | Article |
| id | doaj.art-91fe623e36304ec991f57763217b42a2 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T09:48:17Z |
| publishDate | 2013-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-91fe623e36304ec991f57763217b42a22022-12-21T23:07:35ZengElsevierJournal of Functional Foods1756-46462013-07-015313921401Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich dietK.D.P.P. Gunathilake0Y. Wang1H.P. Vasantha Rupasinghe2Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, P.O. Box 550, Truro, Nova Scotia, Canada B2N 5E3Aquatic and Crop Resource Development, National Research Council of Canada, 550 University Avenue, Charlottetown, Prince Edward Island, Canada C1A 4P3Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, P.O. Box 550, Truro, Nova Scotia, Canada B2N 5E3; Corresponding author. Tel.: +1 902 893 6623; fax: +1 902 893 1404.This study was designed to evaluate a polyphenols-rich fruit-based functional beverage on blood pressure, serum and liver lipid profiles in vivo. Sixty spontaneously hypertensive rats were divided into five groups and were fed with a AIN-93G-diet as the normal control (NC), high cholesterol diet as atherogenic control (AC), and the AC diet with three different beverage dosages (0.5X, 1X, 2X), where X is the equivalence of two portion sizes for an adult (X = 10 mL/kg BW/day) after dose translation. Blood pressure was measured during weeks 2 and 4 using a tail-cuff method. Systolic blood pressures were lowered by the beverage at the supplementation of 1X/2X after 2 week but not after 4 week. The oral administration of the beverage at 1X/2X significantly lowered liver cholesterol and total and non-HDL-cholesterol levels in the serum. Thus, the newly formulated beverage possessed hypolipidaemic effects while showing inconsistent effect in lowering the blood pressure.http://www.sciencedirect.com/science/article/pii/S1756464613001345Functional beverageBlood pressureSpontaneously hypertensive ratsCholesterolLDL |
| spellingShingle | K.D.P.P. Gunathilake Y. Wang H.P. Vasantha Rupasinghe Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet Journal of Functional Foods Functional beverage Blood pressure Spontaneously hypertensive rats Cholesterol LDL |
| title | Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet |
| title_full | Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet |
| title_fullStr | Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet |
| title_full_unstemmed | Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet |
| title_short | Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet |
| title_sort | hypocholesterolemic and hypotensive effects of a fruit based functional beverage in spontaneously hypertensive rats fed with cholesterol rich diet |
| topic | Functional beverage Blood pressure Spontaneously hypertensive rats Cholesterol LDL |
| url | http://www.sciencedirect.com/science/article/pii/S1756464613001345 |
| work_keys_str_mv | AT kdppgunathilake hypocholesterolemicandhypotensiveeffectsofafruitbasedfunctionalbeverageinspontaneouslyhypertensiveratsfedwithcholesterolrichdiet AT ywang hypocholesterolemicandhypotensiveeffectsofafruitbasedfunctionalbeverageinspontaneouslyhypertensiveratsfedwithcholesterolrichdiet AT hpvasantharupasinghe hypocholesterolemicandhypotensiveeffectsofafruitbasedfunctionalbeverageinspontaneouslyhypertensiveratsfedwithcholesterolrichdiet |