Synergistic Regulation of Transcription and Translation in Escherichia coli Revealed by Codirectional Increases in mRNA Concentration and Translation Efficiency

Synergistic Regulation of Transcription and Translation in Escherichia coli Revealed by Codirectional Increases in mRNA Concentration and Translation Efficiency

ABSTRACT Translational regulation was investigated at the genome-scale in Escherichia coli cells. Using the polysome profiling method, the ribosome occupancy (RO) and ribosome density (RD) of different mRNA copies were determined for several hundred mRNAs during the exponential- and stationary-phase...

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Bibliographic Details
Main Authors: Huong Le Nguyen, Marie-Pierre Duviau, Sandrine Laguerre, Sébastien Nouaille, Muriel Cocaign-Bousquet, Laurence Girbal
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
Escherichia coli
gene expression regulation
mRNA concentration
polysome profiling
ribosome density
ribosome occupancy
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02041-21

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