Analysis of TP53 Codon 72 Gene Polymorphism in Patients with Endometriosis in Isfahan
Background: Endometriosis is a common disease among women which is a result of endometrial tissue growth outside the uterus. However, its cause is still unclear. This study surveyed TP53 codon 72 gene polymorphism among 90 patients suffering from endometriosis and 90 healthy subjects, as the control...
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Isfahan University of Medical Sciences
2011-12-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/755 |
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| author | Mehdi Nikbakht Dastjerdi Bahram Eslami Farsani Roshanak Abutorabi Rasul Salehi Mohammad Hossein Sanei |
| author_facet | Mehdi Nikbakht Dastjerdi Bahram Eslami Farsani Roshanak Abutorabi Rasul Salehi Mohammad Hossein Sanei |
| author_sort | Mehdi Nikbakht Dastjerdi |
| collection | DOAJ |
| description | Background: Endometriosis is a common disease among women which is a result of endometrial tissue growth outside the uterus. However, its cause is still unclear. This study surveyed TP53 codon 72 gene polymorphism among 90 patients suffering from endometriosis and 90 healthy subjects, as the control group, in Isfahan.
Methods: Different genotypes of TP53 codon 72 gene were determined by polymerase chain reaction (PCR).
Findings: The frequency of Arg/Arg (Arginine/Arginine) genotype in subjects with endometriosis and healthy individuals were 28.9% and 42.2%, respectively. In addition, the frequency of Pro/Pro (Proline/Proline) genotype in patients with endometriosis and healthy participants were 15.6% and 3.3%, respectively. The frequency of heterozygotes Arg/Pro was 55.6% in endometriosis patients and 54.45% in healthy subjects. Comparing the frequency of Pro/Pro genotype with the two other genotypes in both groups revealed a statistically significant difference between the control and endometriosis groups [P < 0.05; CI = 95%; OR = 5.34 (range: 1047-19.29)].
Conclusion: The present research showed that Pro/Pro genotype of TP53 codon 72 gene is a predisposing genetic factor for endometriosis occurrence in Isfahan. |
| first_indexed | 2024-03-12T09:03:55Z |
| format | Article |
| id | doaj.art-9201e98e535a4562913e4bea15b49957 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:03:55Z |
| publishDate | 2011-12-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-9201e98e535a4562913e4bea15b499572023-09-02T15:29:44ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2011-12-012915715091516769Analysis of TP53 Codon 72 Gene Polymorphism in Patients with Endometriosis in IsfahanMehdi Nikbakht Dastjerdi0Bahram Eslami Farsani1Roshanak Abutorabi2Rasul Salehi3Mohammad Hossein Sanei4Associate Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMSc Student, Student Research Committee, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Endometriosis is a common disease among women which is a result of endometrial tissue growth outside the uterus. However, its cause is still unclear. This study surveyed TP53 codon 72 gene polymorphism among 90 patients suffering from endometriosis and 90 healthy subjects, as the control group, in Isfahan. Methods: Different genotypes of TP53 codon 72 gene were determined by polymerase chain reaction (PCR). Findings: The frequency of Arg/Arg (Arginine/Arginine) genotype in subjects with endometriosis and healthy individuals were 28.9% and 42.2%, respectively. In addition, the frequency of Pro/Pro (Proline/Proline) genotype in patients with endometriosis and healthy participants were 15.6% and 3.3%, respectively. The frequency of heterozygotes Arg/Pro was 55.6% in endometriosis patients and 54.45% in healthy subjects. Comparing the frequency of Pro/Pro genotype with the two other genotypes in both groups revealed a statistically significant difference between the control and endometriosis groups [P < 0.05; CI = 95%; OR = 5.34 (range: 1047-19.29)]. Conclusion: The present research showed that Pro/Pro genotype of TP53 codon 72 gene is a predisposing genetic factor for endometriosis occurrence in Isfahan.http://jims.mui.ac.ir/index.php/jims/article/view/755PolymorphismTP53 codon 72 geneEndometriosis |
| spellingShingle | Mehdi Nikbakht Dastjerdi Bahram Eslami Farsani Roshanak Abutorabi Rasul Salehi Mohammad Hossein Sanei Analysis of TP53 Codon 72 Gene Polymorphism in Patients with Endometriosis in Isfahan مجله دانشکده پزشکی اصفهان Polymorphism TP53 codon 72 gene Endometriosis |
| title | Analysis of TP53 Codon 72 Gene Polymorphism in Patients with Endometriosis in Isfahan |
| title_full | Analysis of TP53 Codon 72 Gene Polymorphism in Patients with Endometriosis in Isfahan |
| title_fullStr | Analysis of TP53 Codon 72 Gene Polymorphism in Patients with Endometriosis in Isfahan |
| title_full_unstemmed | Analysis of TP53 Codon 72 Gene Polymorphism in Patients with Endometriosis in Isfahan |
| title_short | Analysis of TP53 Codon 72 Gene Polymorphism in Patients with Endometriosis in Isfahan |
| title_sort | analysis of tp53 codon 72 gene polymorphism in patients with endometriosis in isfahan |
| topic | Polymorphism TP53 codon 72 gene Endometriosis |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/755 |
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