The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease
Much of the early research into AD relies on a neuron-centric view of the brain, however, evidence of multiple altered cellular interactions between glial cells and the vasculature early in AD has been demonstrated. As such, alterations in astrocyte function are widely recognized a contributing fact...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1056507/full |
| _version_ | 1797986790876905472 |
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| author | Richard J. Elsworthy Richard J. Elsworthy Eric J. Hill Connor Dunleavy Sarah Aldred Sarah Aldred |
| author_facet | Richard J. Elsworthy Richard J. Elsworthy Eric J. Hill Connor Dunleavy Sarah Aldred Sarah Aldred |
| author_sort | Richard J. Elsworthy |
| collection | DOAJ |
| description | Much of the early research into AD relies on a neuron-centric view of the brain, however, evidence of multiple altered cellular interactions between glial cells and the vasculature early in AD has been demonstrated. As such, alterations in astrocyte function are widely recognized a contributing factor in the pathogenesis of AD. The processes by which astrocytes may be involved in AD make them an interesting target for therapeutic intervention, but in order for this to be most effective, there is a need for the specific mechanisms involving astrocyte dysfunction to be investigated. “α disintegrin and metalloproteinase” 10 (ADAM10) is capable of proteolytic cleavage of the amyloid precursor protein which prevents amyloid-β generation. As such ADAM10 has been identified as an interesting enzyme in AD pathology. ADAM10 is also known to play a role in a significant number of cellular processes, most notable in notch signaling and in inflammatory processes. There is a growing research base for the involvement of ADAM10 in regulating astrocytic function, primarily from an immune perspective. This review aims to bring together available evidence for ADAM10 activity in astrocytes, and how this relates to AD pathology. |
| first_indexed | 2024-04-11T07:37:33Z |
| format | Article |
| id | doaj.art-92068887c83f4850a6d8e3980cc8aaa9 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T07:37:33Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-92068887c83f4850a6d8e3980cc8aaa92022-12-22T04:36:40ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-11-011410.3389/fnagi.2022.10565071056507The role of ADAM10 in astrocytes: Implications for Alzheimer’s diseaseRichard J. Elsworthy0Richard J. Elsworthy1Eric J. Hill2Connor Dunleavy3Sarah Aldred4Sarah Aldred5School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomCentre for Human Brain Health, University of Birmingham, Birmingham, United KingdomSchool of Biosciences, Aston University, Birmingham, United KingdomSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomCentre for Human Brain Health, University of Birmingham, Birmingham, United KingdomMuch of the early research into AD relies on a neuron-centric view of the brain, however, evidence of multiple altered cellular interactions between glial cells and the vasculature early in AD has been demonstrated. As such, alterations in astrocyte function are widely recognized a contributing factor in the pathogenesis of AD. The processes by which astrocytes may be involved in AD make them an interesting target for therapeutic intervention, but in order for this to be most effective, there is a need for the specific mechanisms involving astrocyte dysfunction to be investigated. “α disintegrin and metalloproteinase” 10 (ADAM10) is capable of proteolytic cleavage of the amyloid precursor protein which prevents amyloid-β generation. As such ADAM10 has been identified as an interesting enzyme in AD pathology. ADAM10 is also known to play a role in a significant number of cellular processes, most notable in notch signaling and in inflammatory processes. There is a growing research base for the involvement of ADAM10 in regulating astrocytic function, primarily from an immune perspective. This review aims to bring together available evidence for ADAM10 activity in astrocytes, and how this relates to AD pathology.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1056507/fullastrocyteADAM10 (a disintegrin and metalloprotease 10)inflammationAlzheimer’s diseaseamyloid-beta |
| spellingShingle | Richard J. Elsworthy Richard J. Elsworthy Eric J. Hill Connor Dunleavy Sarah Aldred Sarah Aldred The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease Frontiers in Aging Neuroscience astrocyte ADAM10 (a disintegrin and metalloprotease 10) inflammation Alzheimer’s disease amyloid-beta |
| title | The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease |
| title_full | The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease |
| title_fullStr | The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease |
| title_full_unstemmed | The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease |
| title_short | The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease |
| title_sort | role of adam10 in astrocytes implications for alzheimer s disease |
| topic | astrocyte ADAM10 (a disintegrin and metalloprotease 10) inflammation Alzheimer’s disease amyloid-beta |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1056507/full |
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